Research Wing

Ẕefat, Israel

Research Wing

Ẕefat, Israel
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Gilbey P.,Head and Neck Surgery Unit | Gilbey P.,Bar - Ilan University | Bretler S.,Head and Neck Surgery Unit | Sharabi-Nov A.,Research Wing | And 3 more authors.
Paediatric Anaesthesia | Year: 2015

Background Surgeons have searched for the technique or medication that will produce a 'painless tonsillectomy'; however, this seems to be an impossible goal. Previous studies have shown that perioperative acupuncture may be a useful adjunct for acute postoperative pain and that acupuncture, in addition to nonsteroidal anti-inflammatory drugs, is effective in adults for the treatment of postoperative swallowing pain after tonsillectomy. Acupuncture has been shown to be safe in children. A retrospective review of acupuncture for posttonsillectomy pain in juvenile patients showed a significantly reduced pain score immediately after treatment. Aim To examine whether acupuncture, in addition to conventional analgesic treatment, will be effective in the treatment of posttonsillectomy pain in children. Methods We conducted a randomized, controlled, single-blinded study comparing conventional postoperative analgesic treatment with the same regime plus acupuncture to assess whether postoperative treatment of children aged 3-12 years undergoing tonsillectomy with acupuncture will reduce pain and to examine possible unwanted effects of this treatment. Results Sixty children were recruited and randomly divided into a study group and a control group. The results indicate that in the study group, there was less pain, less analgesic drug consumption, and higher patient/parent satisfaction with analgesic treatment scores. No adverse effects were recorded. Conclusions Acupuncture, in addition to conventional analgesic treatment, is an effective treatment for posttonsillectomy pain. Acupuncture is safe and well received by children and their parents. © 2015 John Wiley & Sons Ltd.


Ranjan S.,Vellore Institute of Technology | Ranjan S.,Research Wing | Dasgupta N.,Vellore Institute of Technology | Rajendran B.,Vellore Institute of Technology | And 3 more authors.
Environmental Science and Pollution Research | Year: 2016

Titanium dioxide nanoparticles (TNPs) are widely used in the pharmaceutical and cosmetics industries. It is used for protection against UV exposure due to its light-scattering properties and high refractive index. Though TNPs are increasingly used, the synthesis of TNPs is tedious and time consuming; therefore, in the present study, microwave-assisted hybrid chemical approach was used for TNP synthesis. In the present study, we demonstrated that TNPs can be synthesized only in 2.5 h; however, the commonly used chemical approach using muffle furnace takes 5 h. The activity of TNP depends on the synthetic protocol; therefore, the present study also determined the effect of microwave-assisted hybrid chemical approach synthetic protocol on microbial and cytotoxicity. The results showed that TNP has the best antibacterial activity in decreasing order from Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The IC50 values of TNP for HCT116 and A549 were found to be 6.43 and 6.04 ppm, respectively. Cell death was also confirmed from trypan blue exclusion assay and membrane integrity loss was observed. Therefore, the study determines that the microwave-assisted hybrid chemical approach is time-saving; hence, this technique can be upgraded from lab scale to industrial scale via pilot plant scale. Moreover, it is necessary to find the mechanism of action at the molecular level to establish the reason for greater bacterial and cytotoxicological toxicity. [Figure not available: see fulltext.] © 2016, Springer-Verlag Berlin Heidelberg.


Dasgupta N.,Vellore Institute of Technology | Ranjan S.,Vellore Institute of Technology | Ranjan S.,Research Wing | Mundra S.,Vellore Institute of Technology | And 2 more authors.
International Journal of Food Properties | Year: 2016

The present study was carried out to fabricate the food grade Vitamin E acetate nanoemulsion using edible mustard oil and to evaluate its improved bioactivities. A food-grade Vitamin E acetate nanoemulsion was fabricated using the edible mustard oil and surfactant Tween-80. Flocculation was not observed for 15 days. The nanoemulsion was characterized for droplet morphology and size distribution using atomic force microscope and zetasizer, respectively. We observe a stable nanoemulsion of spherical morphology and a size distribution of 86.45 ± 3.61 nm. Further, the high-performance liquid chromatography method was used to determine the Vitamin E acetate concentration and encapsulation efficiency for the stable nanoemulsion. These nanoemulsions showed improved bioactivity, antioxidant, and antimicrobial activity and could be potentially used to increase the shelf life of fruit juice. Copyright © 2015 Taylor & Francis Group, LLC.


Pikkel D.,Risk Management and Patient Safety Unit | Igal Y.S.P.,Bar - Ilan University | Sharabi-Nov A.,Research Wing | Sharabi-Nov A.,Tel-Hai Academic College | And 2 more authors.
Risk Management and Healthcare Policy | Year: 2016

Objective: Risk taking affects human behavior in general and decisions in medicine in particular. We used game theory to assess physicians’ risk-taking tendencies. Methods: Physicians were recruited to the study by advertisement. It was explained that they would receive a sum of money for correct prediction of the flipping of a coin. They could try to sell their opportunity to flip the coin for an amount of money they determined. The sum offered by the participants was considered an indicator of risk taking. A demographic questionnaire assessed age, sex, seniority, and area of specialization of the participants. A multivariate analysis assessed associations between risk-taking behavior and, seniority, and specialization. Results: Sixty-two physicians participated, 36 males and 26 females, seniority 1-34 years. Of a possible range of 0-10, the mean score for risk taking was 5.5 - just slightly more than indifference. Negative correlations were found between risk taking and seniority, and between risk taking and age (β =−0.45, P,0.001 for both). Surgeons and anesthesiologists showed greater risk taking than did other physicians (β =0.69, P,0.05); and females less than males, though the latter correlation was not statistically significant. Conclusion: Understanding the tendency of physicians to risk taking may elucidate their decision-making processes and contribute to understanding of causes of adverse events and to the education of physicians. © 2016 Pikkel et al.


Gilbey P.,Head & Neck Surgery Unit | Gilbey P.,Bar - Ilan University | Livshits L.,Head & Neck Surgery Unit | Sharabi-Nov A.,Research Wing | And 3 more authors.
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2015

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. The probiotic Streptococcus salivarius has been shown to be effective in reducing the frequency of recurrent pharyngeal infections in children and adult populations. However, probiotics have not yet been evaluated in the treatment of acute pharyngotonsillitis in adults. We aimed to examine whether the addition of S. salivarius probiotics to the routine therapy of acute pharyngotonsillitis in adult patients may shorten disease duration and reduce symptom severity. This study was a prospective, randomized, placebo-controlled, double-blinded study comparing treatment with probiotics to placebo in addition to antibiotics in patients who were hospitalized with severe pharyngotonsillitis. Laboratory results, pain levels, body temperature, and daily volume of fluids consumed were recorded for both groups. Sixty participants were recruited, 30 for each group. No statistically significant differences between the two groups were observed regarding any of the major clinical and laboratory parameters examined. Supplement probiotic treatment with S. salivarius in patients with acute pharyngotonsillitis treated with penicillin is ineffective in relation to the parameters examined in this study and we cannot, therefore, recommend the use of S. salivarius during active pharyngotonsillar infection treated with penicillin. © 2015, Springer-Verlag Berlin Heidelberg.


Pikkel D.,Assuta Hospital | Sharabi-Nov A.,Research Wing | Sharabi-Nov A.,Tel-Hai Academic College | Pikkel J.,Ziv Medical Center | Pikkel J.,Bar - Ilan University
International Journal of Risk and Safety in Medicine | Year: 2014

BACKGROUND: Wrong site confusions are among the most common mistakes in operations of twosome organs. PURPOSE: To examine the frequency of wrong sided confusions that could theoretically occur in various surgeries in the absence of preoperative verification. METHODS: Ten cataract surgeons, twelve orthopedic surgeons and 6 ENT surgeons participated in the study. The surgeons were asked to fill a questionnaire that included their demographic data, occupational habits and their approach to and handling of patients preoperatively. On the day of operation the surgeons were asked to recognize the side of the operation from the patient's name only. At the second stage of the study, surgeons were asked to recognize the side of the operation while standing a two meter distance from the patient's face. Surgeons' answers were compared to the actual operation side. Patients then underwent a full 'time out' procedure, which included side marking before the operation. RESULTS: Of a total of 67 ophthalmic patients, 52 orthopedic patients and 26 ENT patients the surgeons correctly identified the operated side in 111 (76.5%) by name and in 126 (87%) by looking at patients' faces. Wrong side identification correlated with the time lapsed from the last preoperative examination (p = 0.034). The number of cataract surgeries performed by the same surgeon (on the same day) also correlated to the number of wrong identifications (p = 0.001) in ophthalmology. Orthopedic surgeons were more accurate in identifying the operated site Surgeon seniority or age did not correlate to the number of wrong identifications. CONCLUSIONS: This study illustrates the high error that can result in the absence of side marking prior to cataract surgery, as well as in operations on other twosome organs. © 2014 - IOS Press and the authors.


Pikkel J.,Ziv Medical Center | Pikkel J.,Bar - Ilan University | Chassid O.,Ziv Medical Center | Sharabi-Nov A.,Research Wing | And 3 more authors.
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2013

Background: To investigate a possible structural difference in the retina of hydroxychloroquine (Plaquenil)-treated patients as an explanation for the protective effect of this medication against age-related macular degeneration (AMD). Methods: In this retrospective study, we compared the mean thickness of the retinal outer band (consisting of the Bruch's membrane and retinal pigment epithelium layer), as measured by optical coherence tomography (OCT), of 54 eyes of 27 hydroxychloroquine-treated rheumatoid arthritis patients (study group), 40 eyes of 20 healthy similar aged individuals (control group I), and 22 eyes of 11 non-hydroxychloroquine-treated rheumatoid arthritis patients (control group II). Results: The mean thicknesses of the outer band of the retinal pigment epithelium layer was 60.4 ± 7.4, 43.3 ± 2.7, and 39.7 ± 3.6 μm for the study group, control group I, and control group II, respectively. P values for differences in mean thicknesses were < 0.0001 between the study group and each of the control groups, and 0.086 between the two control groups. Conclusion: Treatment with hydroxychloroquine was associated with increased thickness of the outer band of the retinal pigment epithelium layer. This finding may explain the protective effect of hydroxychloroquine against age-related macular degeneration (AMD). © 2013 Springer-Verlag Berlin Heidelberg.


PubMed | Bar - Ilan University, Ziv Medical Center, Tel-Hai Academic College and Head & Neck Surgery Unit
Type: | Journal: Acta paediatrica (Oslo, Norway : 1992) | Year: 2016

Improved communication with staff during a childs hospitalisation is an important determinant of family satisfaction. We examined whether displaying staff photographs in prominent locations would help children and their parents or guardians to recognise staff and whether this enhanced identification would improve parental satisfaction with their childs hospitalisation.No photographs were displayed during the first part of the study. During the second part of the study, staff photographs were placed in prominent locations throughout the paediatric ward. Parents filled in a satisfaction questionnaire on discharge and the children and their parents were asked how many staff members they could name.The children named a significantly larger number of staff members in phase two than phase one, while the parents score was unchanged. Overall parental satisfaction was significantly higher in phase two. The parents age, the duration of the childs hospitalisation and taking part in phase two of the study were significant predictors of parental satisfaction.When children were more able to recognise and name hospital staff, this indirectly improved parental satisfaction, even if the number that parents could identify remained unchanged. Displaying staff photos is a simple way of increasing parental satisfaction during a childs hospitalisation. This article is protected by copyright. All rights reserved.


PubMed | Sree Mookambika Institute of Dental science, Rajan Dental Institute, Research Wing and Edens Dental and Maxillofacial Hospital
Type: Journal Article | Journal: Journal of maxillofacial and oral surgery | Year: 2015

The study reports the authors experience in managing temporomandibular joint (TMJ) ankylosis in Chennai, India (1995-2006) and compares the surgical modalities used. Forty-five patients (67 joints) were reviewed in this retrospective study. Pre- and post-operative assessment included history, radiological, physical examination, and range of mouth opening. Age, gender, aetiology, joint(s) affected, surgical modality, complications and follow-up periods were evaluated. Various types (fibrous, fibroosseous and bony) of TMJ ankylosis were diagnosed. Trauma was the commonest aetiology. The patients age range was 2-50years, 51.1% were males and the follow-up period ranged from 14 to 96months. Average mouth opening was significantly increased to 32mm 12months post-operatively. Mouth opening was compared following different interpositional materials like temporalis interpositioning (33mm), costochondral graft (30.6mm) and autograft (30mm). Minor and major complications were encountered in 37.4% of cases, including 6.7% recurrence rate. Early release of TMJ ankylosis; reconstruction of the ramus height with distraction osteogenesis or bone grafting combined with interpositional arthroplasty, followed by vigorous physiotherapy is a successful strategy for the management of TMJ ankylosis.


Chaturvedi C.S.,Central Institute of Fisheries Education | Singh R.K.,Research Wing | Panday A.K.,National Bureau of Fish Genetic Resources
Biochemical and Cellular Archives | Year: 2012

The endangered Ompok pabda (butterfish), weight range 80-130 gm, were successfully induced bred using ovaprim @ 1.0-1.5 ml/kg body weight of females and 0.5 ml/kg of males (single injection) under captivity. Breeding sets comprising males and females in ratio of 2:1, released in hapa under shower system, were bred after 12-16 hours of the drug administration without sacrificing the males. Latency period for breeding varied between 10-16 hours of the drug injection. Fertilization ranged from 60-80% and hatching success of 75% in flow-through hatchery system. Of the total 1,57,300 hatchlings reared during the induced breeding operations, 79,300 fry were produced with 50.4% survival while 23,580 seed of the non-air-breathing butterfish were raised with 29.8% survival. The observed successful induced breeding of Ompok pabda in all the sets and better larval survival in flow-through-hatchery pave the way for its mass seed production for conservation aquaculture and rehabilitation of this endangered species in the depleted water bodies.

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