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News Article | May 22, 2017
Site: www.eurekalert.org

Babies born preterm run a higher risk of heart failure during childhood and adolescence than those born at full term, researchers at Karolinska Institutet in Sweden report. The registry-based study is published in The Journal of the American College of Cardiology (JACC). More and more babies survive increasingly preterm births. Babies born prematurely are exposed to life outside the womb at a time when their organs are yet to fully mature and their bodies are not entirely prepared for the radical transition from fetus to neonate. In recent years, scientists have become all the more interested in the consequences of preterm birth on, amongst other things, cardiovascular health in young adults. Complementing previous studies indicating a higher risk of hypertension, stroke and fatal cardiovascular disease, researchers at Karolinska Institutet have now uncovered a hitherto unknown connection between preterm birth and heart failure in a registry study of 2.6 million individuals born between 1987 and 2012. "We found that the risk of heart failure was higher for individuals born preterm, and inversely correlated with duration of pregnancy, in that the earlier you're born, the greater the risk," explains lead author Hanna Carr, doctoral student at Karolinska Institutet's Department of Medicine in Solna. The study shows that children born before the 28th week are 17 times more likely to suffer heart failure than those born at full term. Individuals born a little later - in weeks 28 to 31 - ran just over three times the risk. This correlation held when children with birth defects were excluded from the analysis and other possible determinants, such as birth weight, socioeconomic situation and parental heart conditions, were controlled for. The results corroborate earlier studies indicating abnormal development of the cardiovascular system in people born prematurely. The researchers point out, however, that heart failure is very rare in children and young adults, so the risk of developing the condition at a young age is very small, even for people born prematurely. "It could be the case that the higher risk of heart failure remains when they grow older, in which case more people will be affected as heart failure is much more common in older people," says associate professor Anna-Karin Edstedt Bonamy, paediatrician, who led the project. "In general the risk of heart failure can be reduced by adopting a healthy lifestyle, including refraining from tobacco use, keeping physically active, minimising your alcohol consumption and occasionally checking your blood pressure." The study was financed by Stockholm County Council Research Service, the Karolinska Institutet Clinical Scientist Training Programme and the Swedish Heart and Lung Foundation. Publication: "Preterm birth and risk of Heart Failure Up to Early Adulthood", Hanna Carr, Sven Cnattingius, Fredrik Granath, Jonas F. Ludvigsson, Anna-Karin Edstedt Bonamy, Journal of the American College of Cardiology, online 22 May 2017.


The software can be built in-house or purchased as a service through a third party provider. An application programming interface provides various functions such as automate and connections between an API and the applications, ensure consistency between multiple API implementations and monitor traffic from individual apps. It is basically a process of publishing, documenting and overseeing application programming interfaces in a secure, salable environment. The motive of API Management is to allow an organization that publishes an API to monitor the interface’s life cycle and the needs of developers. The growing popularity of Web APIs, advancements of the Internet of Things and Big Data and as well as cost & feature benefits, mobility and app proliferation, increasing number of mobile subscribers, the rise of social media are the factors contributing to the growth of the API Management market. Hence, data security, legacy investments in SOA and Performance Monitoring by skilled professionals are the restraints of the API Management Market. The key players of Global API Management Market report include IBM Corporation (U.S.), Microsoft Corporation (U.S.), Akana, Inc. (U.S.), CA Technologies, Inc. (U.S.), Cloud Elements, Inc. (U.S.), Hewlett-Packard Enterprises Co. (U.S.), Mashape Inc. (U.S.), MuleSoft, Inc. (U.S.) and Oracle Corporation (U.S.), RedHat, Inc. (U.S.), SAP SE (Germany) and others. By component, the market has been bifurcated into solutions, services. • On the Basis of Services, the market can be segmented as training and consulting, integration, support & maintenance. Support & maintenance accounted for the largest market share because they provide most recent fixtures and enhancements to the API management solutions. • On the basis of Deployment the market can be segmented on-premises and cloud based. Further, the market has been segmented into four regions which include- North America, Europe, Asia-Pacific and RoW. Access the market data and market information presented through more than 25 market data tables and 25 figures spread over 100 numbers of pages of the project report “API Management Market - Forecast to 2022” • To provide detailed analysis of the market structure along with forecast of the various segments and sub-segments of the global API Management market. • To provide insights about factors affecting the market growth. • To analyze the global API Management market based porter’s five force analysis etc. • To provide historical and forecast revenue of the market segments and sub-segments with respect to four main geographies and their countries- North America, Europe, Asia, and Rest of the World (ROW). • To provide country level analysis of the market with respect to the current market size and future prospective. • To provide country level analysis of the market for segment by component, service, deployment and region. FIGURE 1 Research Service FIGURE 2 Global API Management Market, By Component (%) FIGURE 3 Global API Management Market, By Service (%) FIGURE 4 Global API Management Market, By Deployment (%) FIGURE 5 Global API Management Market, By Regions (%) At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services. MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients. Our market research studies by products, services, technologies, applications, end users, and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help to answer all their most important questions. In order to stay updated with technology and work process of the industry, MRFR often plans & conducts meet with the industry experts and industrial visits for its research analyst members. For more information, please visit https://www.marketresearchfuture.com


News Article | May 18, 2017
Site: www.prweb.com

Scripophily.com is announcing a Dads and Grads Sales with discounts of up to 35%. Use the coupon code “dadsandgrads” on our online store when checking out for an additional 15% discount. Old paper stock and bond certificates make unique gifts that will last a lifetime. Stock and bond certificates are given as gifts because of their historical significance, beauty and artwork, autographs, notoriety, as well as many other factors. They look terrific framed on walls in homes, offices and dorm rooms. In addition, they continue to increase in popularity as Wall Street continues to dominate the news. "Stock and Bond Certificates are a fun and affordable way to recognize and appreciate financial history" said Bob Kerstein, CEO of Scripophily.com. "Many dad's like the certificates because of the sentimental longing for the past or place with happy personal associations of the company's and industries who issued the certificates. Today's grads can learn from stock and bond certificates about the industrial and stock market booms and busts over time." Kerstein added. Certificates are collected and given as gifts because of their historical significance, beauty and artwork, autographs, notoriety, as well as many other factors. Old Greek, Chinese, Confederate and Panama Canal bond certificates have been very popular this year. In addition, scandals like Lehman Bros. and Enron, and stock certificates signed by John D. Rockefeller and other famous businessmen continue to be our top sellers. Scripophily (scrip-ah-fil-ly) is the name of the hobby of collecting old stock and bond certificates. Certificate values range from a few dollars to more than $500,000 for the most unique and rare items. Tens of thousands of Scripophily buyers worldwide include casual collectors, corporate archives, business executives, museums and serious collectors. The supply of new certificates reaching the collector market has been substantially reduced due to changes in state laws and stock exchanges rules. Many companies are no longer required to issue physical stock and bond certificates by stock exchanges and the Securities and Exchange Commission, a process called “dematerialization.” Stock certificates can now be registered and transferred electronically. Paper stock certificates are slowly being removed and retired from circulation in exchange for electronic recording. This means fewer new paper certificates are reaching the market and older ones are destroyed when they are redeemed. As a result, the supply of paper stock certificates is significantly reduced. Scripophily.com - The Gift of History is the Internets leading buyer and seller of collectible stock and bond certificates and have items on loan for display in the Smithsonian’s Museum of Financial History in New York. Our company has been featured on CNBC, USA Today, Associated Press, Reuters, Nightline, Today Show, Baltimore Sun, and Washington Post and in many other media publications. The company also offers the World’s #1 old stock research service at OldCompany.com and offers high resolution scans for publications. Scripophily.com has over 17,500 selections on its website. In 2011, Scripophily.com, the parent company of Old Company Research Service, acquired the old stock & bond business research service correspondence, archives and copyrights from Herzog & Co., Inc. (formally R.M. Smythe Old Stock Research Services). The acquisition included rights to all reference material published by the Marvyn Scudders Manuals, the Robert D. Fisher Manuals, and Herzog & Co., Inc. as well as all correspondence from the R.M. Smythe Special Library used in the Smythe’s Obsolete Research activities which began in 1880. Scripophily.com /Old Company Research Service, founding member of the Old Stock Exchange, is the successor company to all material published by the Marvyn Scudders Manuals, the Robert D. Fisher Manuals, R.M. Smythe Stock Research Service, and the Herzog & Co., Inc. obsolete research services. Scripophily.com and Old Company Research Services was founded by Bob Kerstein (Bob.com). Bob is a CPA and CGMA, and has more than 40 years of senior management experience in the Cellular, Cable TV, Satellite, Internet, Professional Sports and Entertainment Industries. Bob is also the President of the Professional Scripophily Traders Association (PSTA) and co founder of the American Stock and Bond Collectors Association. For more information on Scripophily.com®, visit http://www.scripophily.com, http://www.oldcompany.com, http://www.scripophily.net, http://www.bestservice.com, http://www.bob.com or call 1-703-787-3552.


News Article | May 15, 2017
Site: en.prnasia.com

SHANGHAI, May 15, 2017 /PRNewswire/ -- WuXi AppTec, a leading global pharmaceutical, biotechnology and medical device open-access capability and technology platform, today announced that it has completed its acquisition of HD Biosciences (HDB), a leading biology focused preclinical drug discovery contract research organization (CRO). Headquartered in Shanghai, HD Biosciences is a leading biology and preclinical service provider. Its plate-based pharmacology & screening capability and AGMTM based target validation are industry leading platforms with great reputation. The company also provides hit identification, lead discovery, in vivo pharmacology and other related services. The acquisition will further strengthen WuXi's R&D capability from target validation to lead discovery and optimization, improving and expanding WuXi's open-access enabling service platform. "My colleagues and I are very excited to be part of WuXi AppTec family," said Dr. Xuehai Tan, Chairman and CEO of HD Biosciences. "The merger will provide additional resources and space to, take our biology focused capabilities to a next level and to speed up the growth of our business into a leading global player within our sector. We will provide better services to our current clients and potentially expand services to WuXi's global customers." Dr. Xuehai Tan will become a Senior Vice President of WuXi AppTec, and the President of HD Biosciences. HD Bioscience will become a wholly owned subsidiary of WuXi AppTec and a member of WuXi's Research Service Division and continue to focus on its core capabilities and business growth. "We are very pleased to have HD Biosciences join the WuXi team," said Dr. Ge Li, Chairman and Chief Executive Officer of WuXi AppTec. "This business combination is an important step in WuXi's development of the most comprehensive capability and technology platform in industry to enable anyone, and any company to discover and develop better medicines and healthcare products for patients, and to realize our vision that 'every drug can be made and every disease can be treated'." WuXi AppTec is a leading global pharmaceutical, biopharmaceutical, and medical device open-access capability and technology platform company with global operations. As an innovation-driven and customer-focused company, WuXi AppTec provides a broad and integrated portfolio of services to help our worldwide customers and partners shorten the discovery and development time and lower the cost of drug and medical device R&D through cost-effective and efficient solutions. With its industry-leading capabilities such as small molecule R&D and manufacturing, cell therapy and gene therapy R&D and manufacturing, and medical device testing, WuXi platform is enabling nearly 3,000 innovative collaborators from more than 30 countries to bring innovative healthcare products to patients, and to fulfill WuXi's dream that "every drug can be made and every disease can be treated."  Please visit http://www.wuxiapptec.com


News Article | May 15, 2017
Site: www.prnewswire.com

"My colleagues and I are very excited to be part of WuXi AppTec family," said Dr. Xuehai Tan, Chairman and CEO of HD Biosciences. "The merger will provide additional resources and space to, take our biology focused capabilities to a next level and to speed up the growth of our business into a leading global player within our sector. We will provide better services to our current clients and potentially expand services to WuXi's global customers." Dr. Xuehai Tan will become a Senior Vice President of WuXi AppTec, and the President of HD Biosciences. HD Bioscience will become a wholly owned subsidiary of WuXi AppTec and a member of WuXi's Research Service Division and continue to focus on its core capabilities and business growth. "We are very pleased to have HD Biosciences join the WuXi team," said Dr. Ge Li, Chairman and Chief Executive Officer of WuXi AppTec. "This business combination is an important step in WuXi's development of the most comprehensive capability and technology platform in industry to enable anyone, and any company to discover and develop better medicines and healthcare products for patients, and to realize our vision that 'every drug can be made and every disease can be treated'." WuXi AppTec is a leading global pharmaceutical, biopharmaceutical, and medical device open-access capability and technology platform company with global operations. As an innovation-driven and customer-focused company, WuXi AppTec provides a broad and integrated portfolio of services to help our worldwide customers and partners shorten the discovery and development time and lower the cost of drug and medical device R&D through cost-effective and efficient solutions. With its industry-leading capabilities such as small molecule R&D and manufacturing, cell therapy and gene therapy R&D and manufacturing, and medical device testing, WuXi platform is enabling nearly 3,000 innovative collaborators from more than 30 countries to bring innovative healthcare products to patients, and to fulfill WuXi's dream that "every drug can be made and every disease can be treated."  Please visit http://www.wuxiapptec.com To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/wuxi-apptec-completes-acquisition-of-hd-biosciences-300457448.html


DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of the "Future of Bionics" report to their offering. This Research Service (RS) offers a strategic perspective on the global emerging industry of bionics technologies. This research service is segmented into three chapters, with the first two focusing on analysis of the top trends from both technology and end-user perspectives. The third chapter brings out the competitive landscape, focusing on strategic scenarios within the industry, reviewing the roles and strategies of both existing and emerging participants in the global market. - What is the role played by NPD (new product development) and research initiatives in improving the overall adoption of bionic technologies? - What are the ongoing shifts in the healthcare needs which are largely driving research and development of bionic prosthetics? - What are the potential technology-enabled business models that could be explored by existing competitors, and new players entering into the global industry for the bionic prosthetics? - Investments in bionic technologies are expected to increase. What are the strategic priorities of existing and new participants in developing the global market? For more information about this report visit http://www.researchandmarkets.com/research/w4dl6w/future_of_bionics


News Article | May 9, 2017
Site: www.prnewswire.com

NEW YORK, May 9, 2017 /PRNewswire/ -- Evaluating the Technology's Role in Driving Strategic Transformation within the Global Bionics Industry This Research Service (RS) offers a strategic perspective on the global emerging industry of bionics technologies. This research service is segmented into three chapters, with the first two focusing on analysis of the top trends from both technology and end-user perspectives. The third chapter brings out the competitive landscape, focusing on strategic scenarios within the industry, reviewing the roles and strategies of both existing and emerging participants in the global market. Read the full report: http://www.reportlinker.com/p04886821/Future-of-Bionics.html Key questions answered in this research service: 1. What is the role played by NPD (new product development) and research initiatives in improving the overall adoption of bionic technologies? 2. What are the ongoing shifts in the healthcare needs which are largely driving research and development of bionic prosthetics? 3. What are the potential technology-enabled business models that could be explored by existing competitors, and new players entering into the global industry for the bionic prosthetics? 4. Investments in bionic technologies are expected to increase. What are the strategic priorities of existing and new participants in developing the global market? Read the full report: http://www.reportlinker.com/p04886821/Future-of-Bionics.html About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place. http://www.reportlinker.com To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/future-of-bionics-300454547.html


Simcox J.A.,University of Utah | McClain D.A.,University of Utah | McClain D.A.,Research Service
Cell Metabolism | Year: 2013

Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions - hereditary hemochromatosis and thalassemia - but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by β cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways. © 2013 Elsevier Inc.


Tregellas J.R.,Research Service | Tregellas J.R.,Aurora University
Biological Psychiatry | Year: 2014

Given the relative inability of currently available antipsychotic treatments to adequately provide sustained recovery and improve quality of life for patients with schizophrenia, new treatment strategies are urgently needed. One way to improve the therapeutic development process may be an increased use of biomarkers in early clinical trials. Reliable biomarkers that reflect aspects of disease pathophysiology can be used to determine if potential treatment strategies are engaging their desired biological targets. This review evaluates three potential neuroimaging biomarkers: hippocampal hyperactivity, gamma-band deficits, and default network abnormalities. These deficits have been widely replicated in the illness, correlate with measures of positive symptoms, are consistent with models of disease pathology, and have shown initial promise as biomarkers of biological response in early studies of potential treatment strategies. Two key features of these deficits, and a guiding rationale for the focus of this review, are that the deficits are not dependent upon patients' performance of specific cognitive tasks and they have analogues in animal models of schizophrenia, greatly increasing their appeal for use as biomarkers. Using neuroimaging biomarkers such as those proposed here to establish early in the therapeutic development process if treatment strategies are having their intended biological effect in humans may facilitate development of new treatments for schizophrenia.


Ayers C.R.,Research Service
International journal of geriatric psychiatry | Year: 2013

Hoarding disorder (HD) is a chronic and debilitating psychiatric condition. Midlife HD patients have been found to have neurocognitive impairment, particularly in areas of executive functioning, but the extent to which this is due to comorbid psychiatric disorders has not been clear. The purpose of the present investigation was to examine executive functioning in geriatric HD patients without any comorbid Axis I disorders (n = 42) compared with a healthy older adult comparison group (n = 25). We hypothesized that older adults with HD would perform significantly worse on measures of executive functioning (Wisconsin Card Sort Task [Psychological Assessment Resources, Lutz, Florida, USA] ( Psychological Assessment Resources, 2003) and the Wechsler Adult Intelligence Scale-IV digit span and letter-number sequencing tests [Pearson, San Antonio, TX, USA]). Older adults with HD showed significant differences from healthy older controls in multiple aspects of executive functioning. Compared with healthy controls, older adults with HD committed significantly more total, non-perseverative errors and conceptual level responses on the Wisconsin Card Sort Task and had significantly worse performance on the Wechsler Adult Intelligence Scale-IV digit span and letter-number sequencing tests. Hoarding symptom severity was strongly correlated with executive dysfunction in the HD group. Compared with demographically-matched controls, older adults with HD have dysfunction in several domains of executive functioning including mental control, working memory, inhibition, and set shifting. Executive dysfunction is strongly correlated with hoarding severity and is not because of comorbid psychiatric disorders in HD patients. These results have broad clinical implications suggesting that executive functioning should be assessed and taken into consideration when developing intervention strategies for older adults with HD. Copyright © 2013 John Wiley & Sons, Ltd.

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