Research Institute of Urgent Pediatric Surgery and Traumatology

Moscow, Russia

Research Institute of Urgent Pediatric Surgery and Traumatology

Moscow, Russia
SEARCH FILTERS
Time filter
Source Type

Alfimova M.V.,Mental Health Research Center | Tomyshev A.S.,Research Institute of Urgent Pediatric Surgery and Traumatology | Lebedeva I.S.,Mental Health Research Center | Akhadov T.A.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova | Year: 2016

13 male patients with schizophrenia and 18 age-matched healthy men underwent structural magnetic resonance imaging and completed the Stroop task which included the switching condition. As compared to controls, the patients showed slowing of color naming in the neutral condition and a reduction of gray matter volume and thickness in the frontal and temporal areas. In healthy subjects, the time of color naming was negatively correlated with gray matter volume in the left cuneus. In the schizophrenia group, there was a positive correlation between the time of color naming and cortical thickness in the middle and inferior frontal gyri of the right hemisphere. These results indicate a change in structural-functional relationships at the early stages of schizophrenia.


Sedov A.S.,RAS Semenov Institute of Chemical Physics | Devet'yarov D.A.,RAS Semenov Institute of Chemical Physics | Semenova Y.N.,RAS Semenov Institute of Chemical Physics | Zav'yalova V.V.,RAS Research Center Kurchatov Institute | And 5 more authors.
Neuroscience and Behavioral Physiology | Year: 2016

Event-related functional MRI (fMRI) was used to study the temporospatial dynamics of the activation of both cortical and subcortical brain formations in humans on execution of goal-directed movements triggered by verbal stimuli. Studies using this method showed that execution of voluntary movements was accompanied by signifi cant activation of various parts of the sensorimotor cortex (primary motor and somatosensory cortex, premotor cortex, supplementary motor area) and the insula and its adjacent structures (operculum) on the side contralateral to the arm being studied, as well as activation of various areas of the ipsilateral cerebellum. Of particular note were the marked reactions of the contralateral striopallidal complex and the ventral thalamus. The dynamics in the involvement of various brain areas in subjects in the phasic and tonic components of voluntary movements were determined. Differences were demonstrated in the dominant foci of brain activity in humans on clenching the right and left hands. These results widen our understanding of the mechanisms of the functioning of the human motor system and the roles of subcortical formations in organizing voluntary movements. © 2016, Springer Science+Business Media New York.


Shendyapina M.V.,Russian Academy of Medical Sciences | Omel'chenko M.A.,Russian Academy of Medical Sciences | Lebedeva I.S.,Russian Academy of Medical Sciences | Kanonovich P.S.,Russian Academy of Medical Sciences | And 6 more authors.
Neuroscience and Behavioral Physiology | Year: 2016

Objective. Much attention in biological psychiatry in recent decades had been paid to functional and structural anomalies of the brain in groups at high risk of developing endogenous psychoses. Linkages between neurophysiological and neuroimaging parameters have been studied in cases of ultra-high risk of developing endogenous psychoses. The present report presents some results from the initial stage of this investigation. Materials and methods. A total of 56 patients aged 17–25 years with nonpsychotic mental disorders were studied. The control group consisted of 20 mentally healthy patients of comparable age and gender. Neurophysiological studies addressed measures characterizing the ability of the brain to “regulate” the volume of incoming information (sensory gating). Localizing proton MR spectroscopy was used simultaneously to determine some measures of metabolic processes in the brain (the glutamate/glutamine index and levels of N-acetylaspartate and choline-containing substances in the dorsolateral prefrontal cortex and thalamus of the left and right hemispheres and the genu and splenium of the corpus callosum. Results and conclusions. The results suggest impairment to the sensory filter in patients of the ultra-high risk group for developing endogenous psychoses; there was no correlation with the metabolic processes studied. These latter were normal or became normal during treatment. © 2016, Springer Science+Business Media New York.


Lebedeva I.S.,Russian Academy of Medical Sciences | Sidorin S.V.,Research Institute of Urgent Pediatric Surgery and Traumatology | Akhadov T.A.,Research Institute of Urgent Pediatric Surgery and Traumatology | Barkhatova A.N.,Russian Academy of Medical Sciences | And 2 more authors.
Neuroscience and Behavioral Physiology | Year: 2014

The structural-functional characteristics of the dorsolateral prefrontal cortex and genu of the corpus callosum were studied, along with their interaction with electrophysiological markers of selective attention processes in 18 mentally healthy subjects and 22 patients with juvenile schizophrenia at the remission onset stage and in remission. No statistically significant intergroup differences were found in terms of N-acetylaspartate and choline-containing substance levels (assayed by proton magnetic resonance spectroscopy), while fractional anisotropy (measured by diffusion-tensor magnetic resonance tomography) in the genu of the corpus callosum was lower in the patients group. The absence of any statistically significant correlations between neuroimaging characteristics and assessments of the severity of psychopathological disorders, along with occasional correlational interactions with P300 parameters, suggest weak involvement of the study structures in processes determining cognitive impairments in patients with juvenile schizophrenia. © 2013 Springer Science+Business Media New York.


Ublinskii M.V.,Russian Academy of Sciences | Semenova N.A.,Russian Academy of Sciences | Lukovkina O.V.,Research Institute of Urgent Pediatric Surgery and Traumatology | Sidorin S.V.,Russian Academy of Sciences | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia. © 2015, Springer Science+Business Media New York.


Ippolitov E.V.,Russian Academy of Sciences | Novikov M.M.,Russian Academy of Sciences | Sviridov A.P.,Russian Academy of Sciences | Plyakin V.A.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Bulletin of the Russian Academy of Sciences: Physics | Year: 2016

A technique for the stereolithographic manufacturing of plastic casts of the costochondral complex is developed using computer tomography scans of real patients for preoperative simulations of the laser thermoplastics of children’s funnel and keeled chests. © 2016, Allerton Press, Inc.


Lebedeva I.S.,Russian Academy of Medical Sciences | Semenova N.A.,RAS Semenov Institute of Chemical Physics | Petryaikin A.V.,Research Institute of Urgent Pediatric Surgery and Traumatology | Agrafonov A.Y.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Human Physiology | Year: 2010

The results of preliminary analysis at the first stage of the study have demonstrated significant relationships between electrophysiological parameters and the levels of a number of metabolites (measured by proton magnetic resonance spectroscopy) in the dorsolateral prefrontal cortex of the left cerebral hemisphere. The observed relationships are assumed to be mediated by individual-specific characteristics of activation of this cerebral region and its contribution to information processing. The neurophysiological markers of the weakened functional state of the brain are associated with decreased levels of N-acetyl aspartate and choline-containing compounds and an increased level of creatin/phosphocreatin in the tested area of the left prefrontal cortex. © 2010 Pleiades Publishing, Inc.


PubMed | Research Institute of Urgent Pediatric Surgery and Traumatology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2015

Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia.

Loading Research Institute of Urgent Pediatric Surgery and Traumatology collaborators
Loading Research Institute of Urgent Pediatric Surgery and Traumatology collaborators