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Alfimova M.V.,Mental Health Research Center | Tomyshev A.S.,Research Institute of Urgent Pediatric Surgery and Traumatology | Lebedeva I.S.,Mental Health Research Center | Akhadov T.A.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova | Year: 2016

13 male patients with schizophrenia and 18 age-matched healthy men underwent structural magnetic resonance imaging and completed the Stroop task which included the switching condition. As compared to controls, the patients showed slowing of color naming in the neutral condition and a reduction of gray matter volume and thickness in the frontal and temporal areas. In healthy subjects, the time of color naming was negatively correlated with gray matter volume in the left cuneus. In the schizophrenia group, there was a positive correlation between the time of color naming and cortical thickness in the middle and inferior frontal gyri of the right hemisphere. These results indicate a change in structural-functional relationships at the early stages of schizophrenia.


Ublinskii M.V.,Russian Academy of Sciences | Semenova N.A.,Russian Academy of Sciences | Lukovkina O.V.,Research Institute of Urgent Pediatric Surgery and Traumatology | Sidorin S.V.,Russian Academy of Sciences | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia. © 2015, Springer Science+Business Media New York.


Ippolitov E.V.,Russian Academy of Sciences | Novikov M.M.,Russian Academy of Sciences | Sviridov A.P.,Russian Academy of Sciences | Plyakin V.A.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Bulletin of the Russian Academy of Sciences: Physics | Year: 2016

A technique for the stereolithographic manufacturing of plastic casts of the costochondral complex is developed using computer tomography scans of real patients for preoperative simulations of the laser thermoplastics of children’s funnel and keeled chests. © 2016, Allerton Press, Inc.


Lebedeva I.S.,Russian Academy of Medical Sciences | Semenova N.A.,RAS Semenov Institute of Chemical Physics | Petryaikin A.V.,Research Institute of Urgent Pediatric Surgery and Traumatology | Agrafonov A.Y.,Research Institute of Urgent Pediatric Surgery and Traumatology | And 2 more authors.
Human Physiology | Year: 2010

The results of preliminary analysis at the first stage of the study have demonstrated significant relationships between electrophysiological parameters and the levels of a number of metabolites (measured by proton magnetic resonance spectroscopy) in the dorsolateral prefrontal cortex of the left cerebral hemisphere. The observed relationships are assumed to be mediated by individual-specific characteristics of activation of this cerebral region and its contribution to information processing. The neurophysiological markers of the weakened functional state of the brain are associated with decreased levels of N-acetyl aspartate and choline-containing compounds and an increased level of creatin/phosphocreatin in the tested area of the left prefrontal cortex. © 2010 Pleiades Publishing, Inc.


PubMed | Research Institute of Urgent Pediatric Surgery and Traumatology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2015

Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia.

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