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Ublinskii M.V.,RAS Emanuel Institute of Biochemical Physics | Semenova N.A.,RAS Emanuel Institute of Biochemical Physics | Lukovkina O.V.,Research Institute of Urgent Children Surgery and Traumatology | Sidorin S.V.,RAS Emanuel Institute of Biochemical Physics | And 4 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown. © 2015 Springer Science+Business Media New York. Source


Semenova N.A.,RAS Emanuel Institute of Biochemical Physics | Sidorin S.V.,RAS Emanuel Institute of Biochemical Physics | Akhadov T.A.,Research Institute of Urgent Children Surgery and Traumatology | Semenova J.B.,Research Institute of Urgent Children Surgery and Traumatology | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011

The effect of intravenous injection of human umbilical cord blood cells on the levels of N-acetylaspartate, creatine and phosphocreatine, choline-containing compounds, glutamine and glutamate, and myoinositol in morphologically intact areas of the cortex, white matter, and hippocampus of children with consequences of traumatic brain injury was studied by single voxel 1H magnetic resonance spectroscopy. It was shown that cell therapy increases the content of N-acetylaspartate, a marker of functional integrity of neurons, in the white matter and in the cortex at the boundary between the frontotemporal and parietal lobes and reduces neurological deficit. © 2011 Springer Science+Business Media, Inc. Source

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