Research Institute of Therapy and Preventive Medicine

Novosibirsk, Russia

Research Institute of Therapy and Preventive Medicine

Novosibirsk, Russia
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Cherepkova E.V.,Research Institute of Physiology and Fundamental Medicine | Aftanas L.I.,Research Institute of Physiology and Fundamental Medicine | Maksimov N.,Research Institute of Therapy and Preventive Medicine | Maksimov N.,RAS Institute of Cytology and Genetics | And 2 more authors.
Bulletin of experimental biology and medicine | Year: 2016

Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.


Ivanova A.A.,Research Institute of Therapy and Preventive Medicine | Maksimov V.N.,Novosibirsk State Medical University | Ivanoshchuk D.E.,Novosibirsk State University | Orlov P.S.,Novosibirsk State University | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2017

We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group. © 2017 Springer Science+Business Media, LLC


Gagulin I.V.,Research Institute of Therapy and Preventive Medicine | Gafarov V.V.,Research Institute of Therapy and Preventive Medicine | Gromov E.A.,Research Institute of Therapy and Preventive Medicine | Gafarova A.V.,Research Institute of Therapy and Preventive Medicine | Panov D.O.,Research Institute of Therapy and Preventive Medicine
Nevrologiya, Neiropsikhiatriya, Psikhosomatika | Year: 2016

Objective: to study the prevalence of vital exhaustion (VI) and sleep disorders, the pattern of the latter in 45-69-year-old Novosibirsk dwellers (Siberia) with different levels of VI. Patients and methods: A random representative sample of 45-69-year-old women (n=2401) from two Novosibirsk districts were examined within the 2003-2005 HAPIEE (Health, Alcohol and Psychosocial Factors In Eastern Europe) prospective cohort study. Another random representative sample of 45-69 men (n=1770) from two Novosibirsk districts were examined within a subsequent screening study. The entire sample consisted of 4171 residents: men and women were 42.4% and 57.6%, respectively. The mean age of the men was 56.5±7.01 and that of the women was 56.3±7.07. The response rate was as high as 61%. Testing was carried out using the short 14-item version of the Maastricht Questionnaire (MQ) to evaluate VE and the 4-item Jenkins Sleep Questionnaire (JSQ) to investigate sleep quality and duration. Results: The leading determinants of VE were the incidence of fatigue, interrupted sleep, lethargy, the degree of irritability, and a feeling of exhaustion and tiredness. The population examined was found to have a high prevalence of VE and sleep disorders. There was a close correlation between high VE and impaired sleep quality and duration. Conclusion: The high rate of impaired sleep quality and duration in the Novosibirsk population, which is sometimes twice greater than that in other populations, is associated with the high prevalence of depression, anxiety, VE, and hostility among the population. This is due to the high prevalence of cardiovascular diseases. A sleep disorder may cause VE. It is important to promptly establish a psychotherapeutic diagnosis of these conditions, followed by their subsequent correction.


Silkov A.N.,Research Institute of Fundamental and Clinical Immunology | Cherdyntseva N.V.,Russian Academy of Sciences | Maximov V.N.,Research Institute of Therapy and Preventive Medicine | Sennikov S.V.,Research Institute of Fundamental and Clinical Immunology
Medical Immunology (Russia) | Year: 2017

Search for molecular genetic markers of risk and prognosis of breast cancer is an important prospective of modern research. Many molecular mechanisms are involved in pathogenesis of breast cancer and define a wide range of possible candidate genes. The genes of pro-inflammatory cytokine receptors, such as tumor necrosis factor and interleukin-1, are also among potential candidate genes. Numerous functional allelic variants of these genes have been shown which are associated with changed expression of membranebound and soluble forms of the receptors. In addition, they are expressed both on immune cells and epithelial and endothelial cells. They regulate functional status of the cells, synthesis and activities of enzymes controlling extracellular matrix and angiogenesis factors. These functions of tumor necrosis factor and interleukin-1 receptor proteins may contribute to pathogenesis of tumor growth. The aim of present study was to compare frequency of functional allelic variants of genes encoding TNF and IL-1 receptors in breast cancer patients and healthy women. We performed genotyping of distinct SNPs (rs4149569 TNFRSF1A, rs590368 TNFRSF1B, rs2234650 IL1RI, and rs4141134 IL1R2) that previously were shown to be associated with expression of TNF and IL-1 receptors on immune cells. Comparative analysis of the genotype frequencies in the samples under study showed a significantly reduced frequency of CC homozygotes for rs590368 polymorphism (TNFRSF1B gene), and increased ratio of CT heterozygotes for rs2234650 polymorphism (IL1R1 gene) among breast cancer patients. Hence, some gene polymorphisms associated with altered expression levels of TNF and IL-1 receptors on immune cells may represent a factor which may determine involvement of proinflammatory cytokines into pathogenesis of breast cancer. © 2017, SPb RAACI.


PubMed | RAS Institute of Cytology and Genetics, Research Institute of Therapy and Preventive Medicine and Research Institute of Physiology and Fundamental Medicine
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3 untranslated region (3 VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3 VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.


Openko T.G.,Research Institute of Therapy and Preventive Medicine | Reshetnikova O.V.,Research Institute of Therapy and Preventive Medicine | Kurilovich S.A.,Research Institute of Therapy and Preventive Medicine | Svetlova I.O.,Research Institute of Therapy and Preventive Medicine | Belkovets A.V.,Research Institute of Therapy and Preventive Medicine
Voprosy Onkologii | Year: 2014

According to the cancer register in Novosibirsk for the period of 1988-2012 there were studied the incidence and mortality from cancer of the colon and rectum. For rectal cancer indicators declined slightly but similar rates for colon cancer remained highly stable. While the rate of detection of stage I1I-IV colorectal cancer decreased by one third. Men exposed to colorectal cancer more often than women, especially in the older age groups, while there were differences between cancer of the colon and rectum. The authors discuss possibilities of control over the incidence of colorectal cancer. Screening is currently optimal, which includes non-invasive analysis of the fecal samples and colonoscopy that allows diagnosing precancerous colon lesions and early cancer.


Bateneva N.V.,Novosibirsk State University | Voevoda M.I.,Research Institute of Therapy and Preventive Medicine | Smirnov P.N.,Novosibirsk State University | Vyshegurov S.H.,Novosibirsk State University | Fomenko M.S.,Novosibirsk State University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

The aim of our study was to find relationship between changes in the nucleotide sequence of the bovine leukemia provirus structure in cattle of different breed affiliation. The studies were carried out on animals of three breeds: Red Steppe, Holstein Black-and-White, and Ayrshire breed. As a result of conducted research and analysis of restriction maps, 11 pattern groups were identified. Subtypes I-III for each breed were common that confirms the hypothesis of the evolution of viruses depending on breed affiliation. Since all breeds were bred with local cattle, the presence of identical nucleotide sequence is quite understandable.


Chernova A.A.,Krasnoyarsk State Medical University | Nikulina S.Ju.,Krasnoyarsk State Medical University | Tret'jakova S.S.,Krasnoyarsk State Medical University | Maksimov V.N.,Research Institute of Therapy and Preventive Medicine | And 2 more authors.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2014

Background: The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β- adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction. Patients and methods: In this study, 102 people with complete left bundle branch block (45,71±1,852 years) - 46 females and 56 males, and 86 people with complete right bundle branch block (34,59±1,86 years) - 41 females and 45 males. The study was approved by Ethic Committee of the KrasSMU. All participants were included in the study after written informed consent form. Cardiological examination included clinical examination, electrocardiography, echocardiography, Holter monitoring, stresstest, koronaroangiografy and radionuclide method of a myocardium and molecular and genetic researches. Results: Statistically, significant prevalence of a homozygous genotype of DD on rare allele gene ADRA2B in both groups in comparison with group of control is established. The reliable dominance of the homozygous rare genotypes (D allele) of gene ADRA2B were detected in all groups. Conclusion: Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.


Duma S.N.,Research Institute of Therapy and Preventive Medicine | Shcherbakova L.V.,Research Institute of Therapy and Preventive Medicine
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2016

Objective: To analyze the prevalence, methods of diagnosis and treatment of psychogenic dizziness in patients with arterial hypertension and evaluate the efficacy of treatment with noophen and betahistin. Material and methods: Fifty-eight patients were studied. Patients of the main group received noophen and patients of the comparison group were treated with betahistin. Treatment efficacy was assessed on days 1 and 60 by the scores on VAS, HARS, MFI-20 scales. Results and Conclusion: The prevalence of psychogenic dizziness in patients with arterial hypertension was 47%. Noophen in dose 500 mg/day significantly (p<0.001) reduced the severity of dizziness, anxiety, asthenia, and headache compared to baseline and to the efficacy of betahistin as well. The drug showed good tolerability. © 2016, Media Sphera. All rights reserved.


Reshetnikov O.V.,Research Institute of Therapy and Preventive Medicine | Openko T.G.,Novosibirsk State Pedagogical University | Kurilovich S.A.,Research Institute of Therapy and Preventive Medicine
Voprosy Onkologii | Year: 2016

Dynamics of morbidity and mortality from pancreatic cancer in the population of Novosibirsk according to the Population-based Cancer Registry and the Registry of total mortality for 25 years (1988-2012) were analyzed. The morbidity and mortality for the studied period decreased slightly. Incidence rates in middle-aged males are higher than in females but this difference is leveled after 75 years. Possible risk factors for pancreatic cancer as well as issues of screening and prevention are discussed.

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