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Kulvik M.,University of Helsinki | Kulvik M.,The Research Institute of the Finnish economics | Hermans R.,Aalto University | Linnosmaa I.,Finnish National Institute for Health and Welfare | Shalowitz J.,Northwestern University
Applied Radiation and Isotopes | Year: 2015

We have constructed a formal model on cost-benefit of new technology in health care, and apply it on boron neutron capture therapy (BNCT). We assume that the patient health benefit from getting cured in acute treatment is always higher than the patient utility resulting from any long term treatment or death. This assumption makes it possible to evaluate the monetary cost impacts of a new technology and relate these measures to the patient health benefit. © 2015 The Authors. Source


Luukkonen T.,The Research Institute of the Finnish economics | Nedeva M.,University of Manchester
Research Policy | Year: 2010

Increasing the level of integration is currently an important policy objective for European research. This brings to light issues regarding the meaning and nature of integration and integration in research; issues associated with the mechanisms to enable and facilitate higher levels of integration in research as part of a policy process; and issues related to the assessment and evaluation of success or failure of policy instruments. The paper addresses these issues by introducing a nuanced conceptualisation developed with particular reference to the policy task for promoting integration and proposing a framework that captures essential features in integrative processes in research-both at the level of researchers and organisations. Furthermore, an empirical example of a Network of Excellence is used to illustrate how the proposed framework can be applied. © 2010 Elsevier B.V. All rights reserved. Source


Kulvik M.,University of Helsinki | Kulvik M.,The Research Institute of the Finnish economics | Kallio M.,University of Helsinki | Laakso J.,University of Helsinki | And 9 more authors.
Applied Radiation and Isotopes | Year: 2015

We studied the uptake of boron after 100 mg/kg BPA infusion in three meningioma and five schwannoma patients as a pre-BNCT feasibility study. With average tumour-to-whole blood boron concentrations of 2.5, we discuss why BNCT could, and probably should, be developed to treat severe forms of the studied tumours. However, analysing 72 tumour and 250 blood samples yielded another finding: the plasma-to-whole blood boron concentrations varied with time, suggesting that the assumed constant boron ratio of 1:1 between normal brain tissue and whole blood deserves re-assessment. © 2015 Elsevier Ltd. Source

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