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Golovin M.S.,Novosibirsk State Pedagogical University | Balioz N.V.,Research Institute of Physiology and Fundamental Medicine | Aizman R.I.,Novosibirsk State Pedagogical University | Krivoshchekov S.G.,Tomsk State University
Human Physiology

In 18- to 23-year-old athletes specialized in field-and-track athletics, the psychophysiological status (cognitive, psychoemotional, and neurodynamic indicators) and the spectral power of the main EEG rhythms, and the heart rate variability prior to and after the course of audiovisual stimulation (AVS) training (the experimental group) were studied as compared with athletes not receiving AVS (the control group). It has been shown that the AVS training sessions in the experimental group caused improvements to the psychoemotional (the levels of anxiety and neuroticism decreased, while the motivation to achieve success and the hardiness level increased), cognitive, and neurodynamic indicators (the volume of mechanical memory and the speeds of attention switching and simple visual-motor responses increased, while the variation of anticipatory and delayed responses to a moving object became reduced). Increases have also been recorded in the high-frequency EEG α2-subrange rhythm power and the parasympathetic nervous system activity, while the autonomic regulation contour activity was enhanced, and more efficient heart activity at rest was formed after the AVS training course in the experimental group compared to the control. This leads to the conclusion about a positive effect of the AVS training course received by athletes engaged in track-and-field athletics on their psychophysiological parameters and autonomic regulation mechanisms. © 2015, Pleiades Publishing, Inc. Source

Egorov V.N.,Tsivyan Novosibirsk Research Institute Of Traumatology And Orthopedics | Razumnikova O.M.,Research Institute of Physiology and Fundamental Medicine | Stupak V.V.,Tsivyan Novosibirsk Research Institute Of Traumatology And Orthopedics
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova

Objective. To compare parameters of attention in healthy people and patients with neoplasms in different regions of the cerebral cortex and to evaluate quality of life (QoL) indices with regard to impairment of different attention systems. Material and methods. Twenty patients with oncological lesions of the brain (mean age 56.5±8.8 years) who did not undergo surgery were studied. Tumor localization was confirmed using contrast-enhanced computed tomography, the tumor type was histologically verified. A control group included 18 healthy people matched for age, sex and education level. To determine attention system functions, we developed a computed version of the Attention Network Test. Error rate and reaction time for correct responses to the target stimulus, displayed along with neutral, congruent and incongruent signals, were the indicators of the efficacy of selective processes. QoL indices were assessed using SF-36 health survey questionnaire. Results and сonclusion. The readiness to respond to incoming stimuli was mostly impaired in patients with brain tumors. Efficacy of executive attention, assessed as the increase in the number of errors in selection of visual stimuli, was decreased while temporary parameters of the functions of this system were not changed in patients compared to controls. The SF-36 total score was stable in patients with marked reduction in scores on the Role and Emotional Functioning scales. The most severe health impairment measured on the SF-36 scales of role/social emotional functioning and viability was recorded in patients with the lesions of frontal cortical areas compared to temporal/parietal areas. The relationship between SF-36 Health self-rating and attention systems was found. This finding puts the question of the importance of attention characteristics and QoL for survival prognosis of patients with brain tumors. © 2015, Media Sphera. All rights reserved. Source

Kisarova Y.A.,Research Institute of Physiology and Fundamental Medicine | Kaledin V.I.,RAS Institute of Cytology and Genetics | Bogdanova L.A.,Institute of Molecular Pathology and Pathomorphology | Korolenko T.A.,Research Institute of Physiology and Fundamental Medicine
Bulletin of Experimental Biology and Medicine

Ratio between proMMP and active MMP was studied in the dynamics of growth of the Lewis lung adenocarcinoma with lung metastasis. It was shown that tumor growth is associated with an increase in the content of proMMP (day 20; terminal stage), but the level of active MMP in tumor tissue did not significantly change. The development of lung metastasis was accompanied by accumulation of active MMP (days 7, 15, and 20) and a decrease in the content of pro-MMP (days 7, and 20) in comparison with the control. In the spleen of these mice (metastasis-free organ), an increase in the levels of proMMP (day 20) and especially active MMP (days 7, 15, and 20) were found. The results suggest that tumor development shifts the proportion between active MMP and proenzymes in the tumor, lungs with metastasis, and spleen without metastasis. © 2015 Springer Science+Business Media New York. Source

Gevorgyan M.M.,Research Institute of Physiology and Fundamental Medicine | Idova G.V.,Research Institute of Physiology and Fundamental Medicine | Al'perina E.L.,Research Institute of Physiology and Fundamental Medicine | Tikhonova M.A.,RAS Institute of Cytology and Genetics | Kulikov A.V.,Research Institute of Physiology and Fundamental Medicine
Bulletin of Experimental Biology and Medicine

The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×108). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state. © 2016 Springer Science+Business Media New York Source

Litvinenko G.I.,Research Institute of Physiology and Fundamental Medicine | Shurlygina A.V.,Research Institute of Physiology and Fundamental Medicine | Dergacheva T.I.,Research Institute of Clinical and Experimental Lymphology | Mel'Nikova E.V.,Research Institute of Physiology and Fundamental Medicine | Trufakin V.A.,Research Institute of Physiology and Fundamental Medicine
Bulletin of Experimental Biology and Medicine

We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case. © 2015 Springer Science+Business Media New York. Source

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