Research Institute of Phtysiopulmonology

Saint Petersburg, Russia

Research Institute of Phtysiopulmonology

Saint Petersburg, Russia

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Titarenko O.T.,Research Institute of Phtysiopulmonology | Dyakova M.E.,Research Institute of Phtysiopulmonology | Esmedlyaeva D.S.,Research Institute of Phtysiopulmonology | Pavlova M.V.,Research Institute of Phtysiopulmonology | And 3 more authors.
Biomeditsinskaya Khimiya | Year: 2012

Functional activity of circulating phagocytes (macrophages - Ms and neutrophils - Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavcrnous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form was revealed: more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with a zymosane induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the M and N activity, respectively. Participation of intracellular ADA in realization of oxygen-depending processes was demonstrated. Results of the multivariant analysis of the whole complex of the studied phagocyte characteristics, reflect their different roles in ther pathological process a prevailing role of Ms in the firstly diagnosed acute tuberculosis process (IPT) and Ns in the chronic progressive process (FCT).

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