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Ivanova S.A.,University Institute of Mental Health | Filipenko M.L.,Russian Academy of Sciences | Vyalova N.M.,Research Institute of Mental Health | Voronina E.N.,Russian Academy of Sciences | And 6 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2016

Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of CYP2D6 gene (responsible for debrisoquin-4-hydroxylase synthesis) with limbotruncal tardive dyskinesia in patients with schizophrenia receiving neuroleptics for a long time. © 2016 Springer Science+Business Media New York Source


Ivanova S.A.,University Institute of Mental Health | Smirnova L.P.,Research Institute of Mental Health | Shchigoreva Y.G.,Research Institute of Mental Health | Semke A.V.,Research Institute of Mental Health | Bokhan N.A.,University Institute of Mental Health
Bulletin of Experimental Biology and Medicine | Year: 2015

Serum concentrations of oxidized and reduced glutathione were measured in 73 patients with schizophrenia at admission and in dynamics of therapy with traditional and atypical antipsychotic drugs. The level of reduced glutathione in patients with schizophrenia with manifest clinical symptoms was lower than in normal subjects. Atypical neuroleptics produced virtually no effects on the glutathione system, while therapy with typical antipsychotics led to further decrease in the levels of reduced glutathione, thus aggravating the imbalance of metabolic processes typical of schizophrenia. © 2015, Springer Science+Business Media New York. Source


Nevidimova T.I.,Research Institute of Mental Health | Batukhtina E.I.,Research Institute of Mental Health | Vetlugina T.P.,Research Institute of Mental Health | Savochkina D.N.,Research Institute of Mental Health | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

We performed immunophysiological examination of 144 men aged 17–25 years, patients with psychoactive substance dependence, episodic psychoactive drug users, and conditionally healthy individuals. Associations of proinflammatory cytokine production with age, sex, hormone levels, and olfactory and nociceptive indices were revealed in cases of psychoactive drug use and formation of addiction. Predictive models based on the use of androstenone aversion, pressure algometry testing, and immunological parameters were proposed. © 2015, Springer Science+Business Media New York. Source

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