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Karaulov A.,Moscow Medical Academy | Aleshkin V.,Garbichevsky Moscow Gn Research Institute Of Epidemiology And Micro Biology | Slobodenyuk V.,Garbichevsky Moscow Gn Research Institute Of Epidemiology And Micro Biology | Grechishnikova O.,Garbichevsky Moscow Gn Research Institute Of Epidemiology And Micro Biology | And 11 more authors.
Infectious Diseases in Obstetrics and Gynecology | Year: 2010

Based on the results of the comparative analysis concerning relatedness and evolutional difference of the 16S-23S nucleotide sequences of the middle ribosomal cluster and 23S rRNA I domain, and based on identification of phylogenetic position for Chlamydophila pneumoniae and Chlamydia trichomatis strains released from monkeys, relatedness of the above stated isolates with similar strains released from humans and with strains having nucleotide sequences presented in the GenBank electronic database has been detected for the first time ever. Position of these isolates in the Chlamydiaceae family phylogenetic tree has been identified. The evolutional position of the investigated original Chlamydia and Chlamydophila strains close to analogous strains from the Gen-Bank electronic database has been demonstrated. Differences in the 16S-23S nucleotide sequence of the middle ribosomal cluster and 23S rRNA I domain of plasmid and nonplasmid Chlamydia trachomatis strains released from humans and monkeys relative to different genotype groups (group B-B, Ba, D, Da, E, L1, L2, L2a; intermediate group-F, G, Ga) have been revealed for the first time ever. Abnormality in incA chromosomal gene expression resulting in Chlamydia life development cycle disorder, and decrease of Chlamydia virulence can be related to probable changes in the nucleotide sequence of the gene under consideration. Copyright © 2010 Alexander Karaulov et al.


Karaulov A.V.,First Medical University | Slobodenyuk V.V.,Gamaleya Institute of Epidemiology and Microbiology | Aleshkin V.A.,Gamaleya Institute of Epidemiology and Microbiology | Grechishnikova O.G.,Gamaleya Institute of Epidemiology and Microbiology | And 10 more authors.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

Based on the results of the comparative analysis concerning relatedness and evolutional difference of the 16S - 23S nucleotide sequences of the middle ribosomal cluster and 23S rRNA I domain, and based on identification of phylogenetic position for Chlamydophila pneumoniae and Chlamydia trichomatis strains released from monkeys, relatedness of the above stated isolates with similar strains released from humans and with strains having nucleotide sequences presented in the GenBank electronic database has been detected for the first time ever. Position of these isolates in the Chlamydiaceae family phylogenetic tree has been identified. The evolutional position of the investigated original Chlamydia and Chlamydophila strains close to analogous strains from the GenBank electronic database has been demonstrated. Differences in the 16S - 23S nucleotide sequence of the middle ribosomal cluster and 23S rRNA I domain of plasmid and non-plasmid Chlamydia trachomatis strains released from humans and monkeys relative to different genotype groups (group B-B, Ba, D, Da, E, L1, L2, L2a; intermediate group - F, G, Ga) have been revealed for the first time ever. Abnormality in incA chromosomal gene expression resulting in Chlamydia life and development cycle disorder and decrease of Chlamydia virulence can be related to probable changes in the nucleotide sequence of the gene under consideration.


Lapin B.A.,Research Institute of Medical Primatology | Yakovleva L.A.,Research Institute of Medical Primatology | Dzhikidze E.K.,Research Institute of Medical Primatology | Gvozdik T.E.,Research Institute of Medical Primatology | And 3 more authors.
Journal of Medical Primatology | Year: 2015

Background: In spring 2009 in Adler colony of the Institute of Medical Primatology, a large enzootic outbreak of acute intestine infection associated with pathogenic E. coli occurred and caused 5% mortality of population (209 animals). Methods: The epidemiological analysis, bacteriological investigation, postmortem examination, histological analysis, and PCR were used to identify the infectious agent. Results: Marked hemorrhagic diathesis, lethargy, dehydration, diarrhea with blood, wasting, and sometimes dystrophic changes in articular cartilages were noted. Morphologically, hemorrhagic enterocolitis and massive hemorrhages were found. PCR investigation of bacteriologically isolated E. coli characterized it as enteropathogenic and enteroinvasive E. coli. Conclusions: The outbreak in Adler colony slightly differed from similar outbreak in Florida in 2014 by more marked hemorrhagic diathesis and articular changes in some monkeys caused by polyavitaminosis developed in the course of infection. Sensitive to infection were M. mulatta, M. fascicularis, Cercopithecus aethiops, P. hamadryas and anubis, and Cebus capucinus. © 2015 John Wiley & Sons A/S.


Agrba V.Z.,Research Institute of Medical Primatology | Porkhanov V.A.,Research Institute of Medical Primatology | Karal-ogly D.D.,Research Institute of Medical Primatology | Leontyuk A.V.,Research Institute of Medical Primatology | And 8 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2016

Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium. © 2016 Springer Science+Business Media New York

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