Research Institute of Human Morphology

Human, Russia

Research Institute of Human Morphology

Human, Russia

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Yaglova N.V.,Research Institute of Human Morphology | Yaglov V.V.,Research Institute of Human Morphology
Bulletin of Experimental Biology and Medicine | Year: 2017

Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed cytophysiological changes in thyroid epithelium related to impaired transport through the apical membrane, suppressed Golgi complex activity, and impaired thyrotrophic hormone regulation of the secretory functions of thyroid cells, which led to compensatory transition from merocrine to microapocrine secret release. © 2017 Springer Science+Business Media New York


Milovanov A.P.,Research Institute of Human Morphology | Voloshchuk I.N.,Moscow Regional Institute of Obstetrics and Gynecology
Arkhiv Patologii | Year: 2017

Over the last 25 years, there has been new evidence for the need to systematize deported placental cells, by identifying 3 groups according to their size, blocking or passing the pulmonary capillaries. In group 1, deported syncytiotrophoblast is a viable multinucleated complexes 100 to 20 μm in diameter. Their common cytoplasm displays β-hCG immunoexpression. After apoptosis of these cells in the lung capillaries, placental bioproducts directly interact with endothelial cell receptors, by contributing to the gestational rearrangement of the woman's body. In Group 2, placental microparticles are necrotized parts of syncytiotrophoblast microvilli and organelles 1000 to 100 nm in size: they freely pass the lung capillaries, activate the production of proinflammatory cytokines by maternal macrophages, and cause a systemic inflammatory response. In excess they become triggers of extensive endotheliosis and vasospasm. In Group 3, placental nanoparticles (or exosomes) are the smallest structures 120 to 20 nm in size; their numbers in the blood are increased in preeclampsia. The given materials call for further investigation of deported placental cells by standardized studies.


Yaglova N.V.,Research Institute of Human Morphology | Sledneva Y.P.,Research Institute of Human Morphology | Yaglov V.V.,Research Institute of Human Morphology
Bulletin of experimental biology and medicine | Year: 2016

Consumption of low dose DDT from birth until puberty suppressed functional activity of the thyroid gland in rats and leads to destructive changes in the organ during the postpubertal period with compensatory stimulation of secretory activity of thyrocytes aimed at normalization of thyroxin production.


PubMed | Russian National Research Medical University and Research Institute of Human Morphology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

The mechanisms of proangiogenic activity of multipotent stromal cells from human umbilical cord were analyzed in vitro. The absence of secreted forms of proangiogenic growth factor VEGF-A in the culture medium conditioned by umbilical cord-derived multipotent stromal cells was shown by ELISA. However, the possibility of paracrine stimulation of cell proliferation, mobility, and directed migration of endothelial EA.hy926 cells was demonstrated by using MTT test, Transwell system, and monolayer wound modeling. The capacity of multipotent stromal cells to acquire the phenotype of endothelium-like cells was analyzed using differentiation media of three types. It was found that VEGF-A is an essential but not sufficient inductor of differentiation of umbilical cord-derived multipotent stromal cells into CD31+ cells.


Kharlamova A.S.,Research Institute of Human Morphology | Saveliev S.V.,Research Institute of Human Morphology | Protopopov A.V.,Academy of science of the Sakha Republic Yakutia | Maseko B.C.,University of Witwatersrand | And 2 more authors.
Journal of Comparative Neurology | Year: 2015

This study presents the results of an examination of the mummified brain of a pleistocene woolly mammoth (Mammuthus primigenius) recovered from the Yakutian permafrost in Siberia, Russia. This unique specimen (from 39,440-38,850 years BP) provides the rare opportunity to compare the brain morphology of this extinct species with a related extant species, the African elephant (Loxodonta africana). An anatomical description of the preserved brain of the woolly mammoth is provided, along with a series of quantitative analyses of various brain structures. These descriptions are based on visual inspection of the actual specimen as well as qualitative and quantitative comparison of computed tomography imaging data obtained for the woolly mammoth in comparison with magnetic resonance imaging data from three African elephant brains. In general, the brain of the woolly mammoth specimen examined, estimated to weigh between 4,230 and 4,340 g, showed the typical shape, size, and gross structures observed in extant elephants. Quantitative comparative analyses of various features of the brain, such as the amygdala, corpus callosum, cerebellum, and gyrnecephalic index, all indicate that the brain of the woolly mammoth specimen examined has many similarities with that of modern African elephants. The analysis provided here indicates that a specific brain type representative of the Elephantidae is likely to be a feature of this mammalian family. In addition, the extensive similarities between the woolly mammoth brain and the African elephant brain indicate that the specializations observed in the extant elephant brain are likely to have been present in the woolly mammoth. © 2015 Wiley Periodicals, Inc.


PubMed | Russian Academy of Sciences, Yakut State Agricultural Academy, Mammoth Site of Hot Springs Inc., Research Institute of Human Morphology and Yakutian Academy of Science
Type: Journal Article | Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections | Year: 2016

The paper presents the first morphological description of the internal organs of a frozen corpse of the steppe bison Bison priscus (Bojanus, 1827) from the Holocene of northern Yakutia. Necropsy revealed that most of the internal organs, including the brain, heart with the main vessels, and reproductive system were well preserved. It demonstrated that the anatomy of this bison was close to that of the genera Bos and Bison. Trauma or pathological changes in the organs were not detected. The cause of death of the bison remains unknown.


Arutyunyan I.V.,Research Institute of Human Morphology | Kananykhina E.Y.,Research Institute of Human Morphology | Makarov A.V.,Research Institute of Human Morphology
Cellular Transplantation and Tissue Engineering | Year: 2013

We present an overview of current literature data on the different roles of key proangiogenic factor VEGF-A-165' receptors in angiogenesis regulation. VEGFR2 is the major effector receptor and runs intracellular cascades that provide survival, proliferation and migration of endothelial cells, the involvement of progenitor cells, the formation and maturation of new blood vessels. VEGFR1 contrary is the main regulator of the activity of VEGF-A-165, preventing excessive angiogenic response through the mechanism of negative feedback. The article also presents data on the variability of number and ratio of VEGFR1 and VEGFR2 on the surface of different cell types, providing the fine regulation of the VEGF-A-165 pathway. © Human stem cells institute, 2013.


Yaglova N.V.,Research Institute of Human Morphology | Obernikhin S.S.,Research Institute of Human Morphology
Bulletin of Experimental Biology and Medicine | Year: 2016

Differentiation of T cells was studied in the progeny of female C57Bl/6 mice subjected to immunostimulation by administration of concanavalin A or adoptive transfer of concanavalin A-activated splenocytes. Acceleration of T cell maturation during the prepubertal period and decelerated differentiation during the pubertal and post-pubertal periods were revealed. © 2016 Springer Science+Business Media New York


Yaglova N.V.,Research Institute of Human Morphology | Yaglov V.V.,Research Institute of Human Morphology
Biomedit︠s︡inskai︠a︡ khimii︠a︡ | Year: 2016

Changes in secretion of thyroid autoantigenes and production of antithyroid autoantibodies after long-term exposure to low doses of DDT were studied. Changes in serum levels of antithyroid peroxidase antibodies and thyroid peroxidase, attributed to disruption of thyroxine production by DDT were found. Long-term exposure of rats to low doses of DDT revealed no specific impact on serum autoantibodies to all thyroid autoantigenes studied. The increase of the ratio of autoantibody/autoantigen for thyroid peroxidase and thyroglobulin was rather small and thus could not be considered as a significant symptom of thyroid autoimmunity.Abstract available from the publisher.


PubMed | Research Institute of Human Morphology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Differentiation of T cells was studied in the progeny of female C57Bl/6 mice subjected to immunostimulation by administration of concanavalin A or adoptive transfer of concanavalin A-activated splenocytes. Acceleration of T cell maturation during the prepubertal period and decelerated differentiation during the pubertal and post-pubertal periods were revealed.

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