Research Institute of Health science

Palma, Spain

Research Institute of Health science

Palma, Spain
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Jeyabalan S.,Sri Ramachandra University | Subramanian K.,Research Institute of Health science | Cheekala U.M.R.,Sri Ramachandra University | Krishnan C.,Sri Ramachandra University
Journal of Applied Pharmaceutical Science | Year: 2017

Morinda citrifolia (Noni) has been used for centuries to cure or prevent variety of illnesses by traditional medical practitioners in Hawaii and Polynesia. The aim and objective of the present study is to perform GC-MS analysis of Morinda citrifolia fruit extract and in-silico docking analysis of the phytoconstituents identified in Morinda citrifolia fruit extract against targets for antipsychotic drugs like dopamine receptors (D2 and D3). GC-MS analysis was performed and the phytoconstituents of Morinda citrifolia were retrieved from pubchem compound databases. The standard typical antipsychotic and atypical antipsychotic drugs were obtained from drug bank in .mol format. The 3D protein structures of the targets dopamine receptor D2 (PDB ID: 5AER), dopamine receptor D3 (PDB ID: 3PBL) are obtained from Protein Data Bank. In-silico docking analysis was performed by using Molegro virtual docker (MVD). The phytoconstituents with least MolDock score and hydrogen bond interactions shows maximum affinity for the target. The antipsychotic activity of the phytoconstituents of medicinal plants is analyzed by docking score and binding energy. The phytoconstituents from Morinda citrifolia exhibited the binding pattern to that of the standard drugs exhibiting antipsychotic activity by inhibiting D2 and D3 dopamine receptors. © 2017 Srikanth Jeyabalan et al.

Sridharan S.,Pondicherry University | Mohankumar K.,Pondicherry University | Jeepipalli S.P.K.,Pondicherry University | Sankaramourthy D.,Research Institute of Health science | And 6 more authors.
NeuroToxicology | Year: 2015

Oxidative stress and inflammation are some of the contributing factors for dopaminergic neurodegeneration in Parkinson's disease (PD). Though Valeriana wallichii D.C. is known for its nervine activities its effect against PD is yet to be studied. This is the first report on the antioxidant and anti-inflammatory effect of V. wallichii rhizome extract (VWE) in MPTP induced PD mice. GC-MS analysis of VWE indicated the presence of phytoconstituents like isovaleric acid and acacetin. PD induced mice were treated orally with three different doses (50, 100 and 200mg/kg body weight (BW)) of VWE for 14 days and their behavioural changes were studied on days 0, 8, 13 and 21. The levels of striatal dopamine, mid brain tyrosine hydroxylase positive (TH+) cell count, TH protein expression, reactive oxygen species (ROS), lipid peroxidation (LPO), antioxidants and inflammatory cytokines were analysed. Mid brain glial fibrillary acidic protein (GFAP) expression was assessed by immunohistochemistry and western blotting. Also mid brain histopathological analysis was performed. VWE treatment significantly recuperated the altered behavioural test scores, striatal dopamine levels, mid brain TH+ cell count and TH protein levels, increased GFAP expression and the histopathological changes observed in PD mice. Similarly, diminished levels of antioxidants, elevated levels of ROS, LPO and inflammatory cytokines were also significantly ameliorated following VWE treatment. The effective dose of VWE was found to be 200mg/kg BW. Conclusively, V. wallichii rhizome extract has the potential to mitigate oxidative stress and inflammatory damage in PD. © 2015 Elsevier Inc.

Poovi G.,Research Institute of Health science
Journal of Bionanoscience | Year: 2017

Polymeric nanoparticles (PNPs) hold great promise as versatile nano-carriers for a wide range of therapeutics for various biomedical applications. The ease with which the size, shape, geometry, charge, structure and composition can be controlled will secure their future development and success. Moreover, their nanometer-size polymeric nanoparticles can provide higher solubility of hydrophobic drugs and promotes effective permeation through cell membranes, increases the drug circulation time in blood, target the drug delivery to the desired sites and improves the stability in the blood stream compared to conventional therapeutic nanocarriers. Also, a great number of possibilities to produce and modify polymeric nanocarriers (PNCs) have formed a great expectation of challenging stemmed from the biological features, nanoparticle properties, chemical and physical properties of drugs. Besides, PNCs have great potential to develop new-generation theranostic agents and personalized medicine for clinical treatments. Despite the great progress in PNPs, however, an understanding of the biological barrier, physicochemical characteristics and in-vitro/in-vivo stability prediction of nanoparticles which dictate their in-vivo efficacy and pharmacological challenges, is needed to overcome current bottlenecks in research and development of rationally designed nanoparticles for poorly soluble drugs. To illustrate this point, we are aimed to discuss current challenges in respect to PNCs for nanomedicine and alternative ways for their solutions. Copyright © 2017 American Scientific Publishers All rights reserved.

PubMed | UNFPA, World Health Organization, Ministry of Health and Research Institute of Health science
Type: | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | Year: 2016

To analyze and compare the availability, utilization, and quality of services for maternal and neonatal health in 2010 and 2014 in Burkina Faso.A cross-sectional study of emergency obstetric and neonatal care services (EmONC) in all public and private health facilities in Burkina Faso in 2010 and a sample of 812 health facilities in 2014. The generic tools developed by the Averting Maternal Death and Disability (AMDD) program were used as the basic tools for evaluation.In 2010, 25 health facilities were considered as EmONC health facilities and there were 23 in 2014. In 2010 and 2014, the proportion of births in EmONC health facilities was low (4.5%). The cesarean delivery rate also remained very low, at 0.9% in 2010 and 1.13% in 2014. The proportion of obstetric complications supported in health facilities was 12.3% in 2010 and 17.1% in 2014. The direct complication case fatality rate in EmONC health facilities was 1.6% in 2010 and 1.3% in 2014.The two surveys did not show a significant improvement in the availability, utilization, and quality of maternal and neonatal healthcare services between 2010 and 2014.

PubMed | Ghent University, International Institute For Applied Systems Analysis, Aga Khan University and Research Institute of Health science
Type: | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | Year: 2016

To propose a rationale to improve maternal postpartum care in reproductive, maternal, newborn, and child health (RMNCH) services.We conducted a cross-sectional mixed study in the Kaya health district in Burkina Faso based on two data collection exercises conducted between December 2012 and May 2013. A household survey of 757 mothers in their first year after delivery was processed. It was complemented with a qualitative analysis using in-depth interviews with key informants, focus group discussions with mothers, and participant observation.Postpartum services showed serious weaknesses. Overall, 52% (n=384) of mothers did not receive any maternal postpartum care; however among them, 47% (n= 349) received infant postpartum care.We suggest the integration of maternal postpartum care in RMNCH services as a key step to improving postpartum care. The intervention would require the overcoming of challenges related to the quality and cost of services, and to reaching the poor populations with low education and a high parity.

PubMed | National Health Research Institute, University of Ouagadougou and Research Institute of Health science
Type: | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | Year: 2016

To assess the implementation and effects of the strategy, introduced in June 2011, of making obstetric kits readily available in health facilities in the Adamaoua region of Cameroon.We conducted a quasi-experimental study using an interrupted time series to assess the effects of the strategy, and a case study to evaluate its implementation. The reviewed data were gathered from 13 health facilities over a period from January 2008 to December 2014. Qualitative data were collected from in-depth interviews.The provision of obstetric kits was effective in the intervention health facilities, although some challenges existed and included lack of staff motivation and rampant illegal practices. The number of deliveries and cesareans increased.There is a need to rethink this strategy, given its gaps and shortcomings.

Bado A.R.,Research Institute of Health science | Susuman A.S.,University of the Western Cape
PLoS ONE | Year: 2016

Background The aim of the study was to analyse trends in the relationship between mother's educational level and mortality of children under the year of five in Sub-Saharan Africa, from 1990 to 2015. Data and Methods Data used in this study came from different waves of Demographic and Health Surveys (DHS) of Sub-Saharan countries. Logistic regression and Buis's decomposition method were used to explore the effect of mother's educational level on the mortality of children under five years. Results Although the results of our study in the selected countries show that under-five mortality rates of children born to mothers without formal education are higher than the mortality rates of children of educated mothers, it appears that differences in mortality were reduced over the past two decades. In selected countries for our study, we noticed a significant decline in mortality among children of non-educated mothers compared to the decrease in mortality rates among children of educated mothers during the period of 1990-2010. The results show that the decline in mortality of children under five years was much higher among the children born to mothers who have never received formal education-112 points drop in Malawi, over 80 in Zambia and Zimbabwe, 65 points in Burkina Faso, 56 in Congo, 43 in Namibia, 27 in Guinea, Cameroon, and 22 to 15 in Niger. However, we noted a variation in results among the countries selected for the study-in Burkina Faso (OR = 0.7), in Cameroon (OR = 0.8), in Guinea (OR = 0.8) and Niger (OR = 0.8). It is normally observed that children of mothers with 0-6 years of education are about 20% more likely to survive until their fifth year compared to children of mothers who have not been to school. Conversely, the results did not reveal significant differences between the under-five deaths of children born to non-educated mothers and children of low-level educated mothers in Congo, Malawi and Namibia. Conclusion The decline in under-five mortality rates, during last two decades, can be partly due to the government policies on women's education. It is evident that women's educational level has resulted in increased maternal awareness about infant health and hygiene, thereby bringing about a decline in the under-five mortality rates. This reduction is due to improved supply of health care programmes and health policies in reducing economic inequalities and increasing access to health care. © 2016 Bado, Sathiya Susuman. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed | Directorate of Family Health and Nutrition, Columbia University, University of Ouagadougou and Research Institute of Health science
Type: | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | Year: 2016

To assess the availability and utilization of emergency obstetric and neonatal care (EmONC) in Guinea given the high maternal and neonatal mortality rates.We used the Guinea 2012 needs assessment data collected via a national cross-sectional census of health facilities conducted from September to October 2012. All public, private, and faith-based health facilities that performed at least one delivery during the period of the study were included.A total of 502 health facilities were visited, of which 81 were hospitals. Only 15 facilities were classified as fully functioning EmONC facilities, all of which were reference hospitals. None of the first level health facilities were fully functioning EmONC facilities. The ratio of availability of EmONC was one fully functioning EmONC facility for 745 415 inhabitants. The institutional delivery rate was 32.3% and the proportion of all births in EmONC facilities was 7.1%. Met need for EmONC was 12.2%. Among 201 maternal deaths in EmONC facilities, 69 were due to indirect causes. The intrapartum and very early neonatal death rate was 39 deaths per 1000 live births.The study showed low availability of EmONC services and underutilization of the available services. Further investigation is needed to evaluate the effect of the current policy of user fees exemption for deliveries and prenatal care in Guinea.

Rukumani J.,Research institute of health science
International Journal of Pharma and Bio Sciences | Year: 2015

A evaluative study on effectiveness of coping strategies of menopause among menopausal women at Pondicherry. 500 sample were selected by stratified random sampling technique. The findings shows high significant in the coping strategies among menopausal women after implementing coping strategies.

PubMed | World Health Organization, Donka University National Hospital and Research Institute of Health science
Type: | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | Year: 2016

To analyze the sociocultural determinants that influence the attitude and practices of men toward contraceptive use in Guinea.A sequential, mixed methods, qualitative and quantitative study was carried out in two regions of Guinea with a low rate of contraceptive prevalence, and in the capital city of Conakry. A total of 1170 people (men and women) were interviewed.Findings showed a positive perception of family planning overall, but reluctance to use modern contraception. The reasons for non-use of contraceptive methods were primarily the hope of having many children and religious prohibition associated with customs. Making decisions on contraceptive use within a couple represents a major cause of misunderstanding between spouses. Communication within a couple on the use of contraception is quickly declined by men.The findings demonstrate the need to develop communication strategies within a couple to improve the use of contraceptives.

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