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Liu J.-J.,Research Institute of Field Surgery | Wang X.,Research Institute of Field Surgery | Xiong X.-Q.,Research Institute of Field Surgery | Wang X.-J.,Research Institute of Field Surgery | And 3 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2013

Objective: To observe the left ventricular systolic function of rabbits with sepsis using two-dimensional speckle tracking imaging (STI). Methods: Twenty-four healthy rabbits were divided randomly into experimental group and control group (each n=12). Rabbits in experimental group were given LPS (0.8 mg/kg) by intravenous injection, while in the control group were injected with saline (4 ml/kg). The parameters of conventional echocardiography and 2D STI were obtained before injection of LPS/saline and 2 h, 4 h, 6 h, 8 h, 12 h after injection, including left ventricular end diastolic diameter (LVDd), left ventricular end systolic diameter (LVDs), left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), cardic output (CO), left ventricular global longitudinal strain (GLS), left ventricular global circumferential strain (GCS) and left ventricular global radial strain (GRS). The sample was collected at 6 h, 8 h, 12 h after LPS injection. The pathological changes of cardiac tissue were checked by HE staining. Results: Compared with control group, left ventricular GLS, GCS decreased significantly 2 h and 4 h after LPS injection in experimental group (all P<0.05), while LVEF, LVFS and GRS did not show significant alterations (all P>0.05). At 6 h, 8 h and 12 h after LPS injection, LVDd and LVDs became larger (both P<0.05), LVEF and LVFS decreased significantly (both P<0.05), GLS, GCS, GRS all showed significant decrease in experimental group (all P<0.05). CO did not show alterations before and after the experiment in the two groups (P>0.05). Light microscopy showed that rabbits in experimental group had degeneration, edema and inflammatory cell infiltration, etc. Conclusion: Both conventional ultrasonography and STI can effectively evaluate left ventricular dysfunction at the early phase of sepsis rabbits in hyperdynamic hemodynamics. STI can be more earlier and more sensitively find the abnormality of myocardial deformation in rabbits with sepsis. Copyright © 2013 by the Press of Chinese Journal of Medical Imaging Technology. Source

Bai W.,Research Institute of Field Surgery | Nie Z.-L.,Research Institute of Field Surgery | Huo W.-Q.,Research Institute of Field Surgery | Zhu F.-Q.,Research Institute of Field Surgery | And 2 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

BACKGROUND: Urethral fistula following renal transplantation accounts for 40%-70% of urinary complications, owing to surgical and medical factors. OBJECTIVE: To effectively decrease and avoid attack of urethral fistula after renal transplantation, and prolong the survival of kidney. METHODS: Clinical data from 68 cases following renal transplantation were retrospectively analyzed at the levels of pathogeny, diagnosis and treatment. There were 47 males and 21 females, aging 20-58 years. Urethral fistula occurred at 3-31 days after renal transplantation, and the amount was 60-2 000 mL per day. Based on the principle of the urethral injury classification method, urethral fistula was divided into simple and complex categories, while according to the fistula site, etiology and extent, urethral fistula was divided into low, high and multiple fistula. Attack rate of simple urethral fistula and complex urethral fistula was detected following renal transplantation so as to analyze the pathogeny of urethral fistula. RESULTS AND CONCLUSION: Of 68 cases with urethral fistula following renal transplantation, 47 cases (69.1%) were simple urethral fistula, including 42 cases with ureteral end necrosis, 4 cases with lax anastomotic suture of ureter bladder, and 1 case with ureteral anastomotic badness caused by wound infection, and 21 cases (30.9%) were complex urethral fistula, including 2 cases with renal pelvis fistula, 2 cases with ureter, 11 cases with ureterovesical anastomosis region, 6 cases with ureteral necrosis longer than 2 cm. A lot of causes may induce urethral fistula following renal transplantation. The blood stream, edema, size of fistula, length of the ureter, and operative procedures are selected to ensure free of strain. Urethral fistula can be treated on time on the basis of different situations. Source

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