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Fonina L.A.,RAS Shemyakin Ovchinnikov Institute of Bioorganic Chemistry | Treshchalina E.M.,Russian Academy of Medical Sciences | Belevskaya R.G.,RAS Shemyakin Ovchinnikov Institute of Bioorganic Chemistry | Az'Muko A.A.,Research Institute of Experimental Cardiology | And 3 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2012

The bone marrow-derived peptide Phe-Leu-Gly-Phe-Pro-Thr (MP-1) has been synthesized by the classical methods of peptide chemistry in solution, and its antitumor properties have been studied. It has been shown that MP-1 enhances the efficacy of the cytostatic therapy of lympholeukosis P388, increases the latent period of the growth of P388 tumors implanted in irradiated mice, and reduces the recurrence of the breast adenocarcinoma Ca-755 in mice after the surgery.© Pleiades Publishing, Ltd., 2012.

Gracheva E.V.,Research Institute of Experimental Cardiology | Samovilova N.N.,Research Institute of Experimental Cardiology | Golovanova N.K.,Research Institute of Experimental Cardiology | Piksina G.F.,Research Institute of Experimental Cardiology | And 2 more authors.
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | Year: 2012

Using blood monocytes and lymphocytes from atherosclerotic patients and healthy subjects we have investigated a role of ganglioside GM3 in monocyte adhesion to cultured human umbilical vein endothelial cells (HUVEC). The results showed that activity of GM3 synthase and cellular levels of ganglioside GM3 in blood mononuclear cells from atherosclerotic patients were several-fold higher than those from healthy subjects. In monocytes the activity of GM3 synthase was one order of magnitude higher than in lymphocytes from both groups studied; this suggests the major contribution of monocytes to enhanced biosynthesis and levels of GM3 in mononuclear cells in atherosclerosis. Enrichment of monocytes from healthy subjects with ganglioside GM3 by their incubation in the medium containing this ganglioside increased adhesion of these monocytes to HUVEC up to the level typical for monocytes from atherosclerotic patients. In addition, an increase in CD11b integrin expression comparable to that seen in lipopolysaccharide-activated monocytes was observed. It is suggested that in atherosclerosis the enhanced cellular levels of GM3 in monocytes and lymphocytes may be an important element of cell activation that facilitates their adhesion to endothelial cells and penetration into intima. © 2012 Pleiades Publishing, Ltd.

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