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Kim L.B.,Research Institute of Experimental and Clinical Medicine | Shkurupy V.A.,Novosibirsk State Medical University | Putyatina A.N.,Research Institute of Experimental and Clinical Medicine
Bulletin of Experimental Biology and Medicine | Year: 2016

Structure of proteoglycans in the lungs and total glycosaminoglycan content in blood serum were studied on mouse model of BCG-induced granulomatous inflammation in mice (without destructive processes in the lung parenchyma and granulomas). The maximum level of sulfated glycosaminoglycans in the lungs was detected on postinfection day 30 and was related to their involvement in initiation granulomogenesis and development of granulomas. The maximum level of total glycosaminoglycans in mouse serum on postinfection day 90 coincided with minimum level of sulfated glycosaminoglycans in the lungs. This blood/lungs ratio of glycosaminoglycans can be related to the prevalence of low-molecular-weight hyaluronan fragments promoting inflammation and fibrosis in the lungs observed at the end of the experiment (postinfection day 180). © 2016 Springer Science+Business Media New York Source


Withrow J.J.,University of Alaska Fairbanks | Gibson D.D.,University of Alaska Fairbanks | Gerasimov Y.,Russian Academy of Sciences | Gerasimov N.,Russian Academy of Sciences | And 2 more authors.
Wilson Journal of Ornithology | Year: 2016

We reviewed the taxonomic status of Arctic Warblers (Phylloscopus borealis) sensu lato occurring in North America following the splitting of the complex into three species by the American Ornithologists' Union (Chesser et al. 2014). We used phenotypic and genetic markers to assess the status of this species complex in North America and identified Arctic-type warblers occurring in the Aleutian Islands as Kamchatka Leaf Warblers (P. examinandus). This species occurs at least occasionally through the Bering Sea, to the Alaska mainland, and as far east as arctic Canada. Measurements of Arctic and Kamchatka Leaf warblers were found to differ by only a small degree, offering no simple diagnostic characteristics. In addition, we recommend maintaining the long-recognized Alaska subspecies P. b. kennicotti as a synonym of P. b. borealis. © 2016 The Wilson Ornithological Society. Source


Shchepankevich L.A.,Research Institute of Experimental and Clinical Medicine | Nikolaev Y.A.,Research Institute of Experimental and Clinical Medicine | Dolgova N.A.,Research Institute of Experimental and Clinical Medicine | Chipova D.T.,Kabardino-Balkarian State University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2016

Objectives. Evaluation of effectiveness of Mexidol in optimization of hypolipidemic therapy in ischemic stroke and diabetes mellitus patients. Material and methods. Authors analyzed the indicators of lipid status: total cholesterol, low-density lipoproteins, high density lipoproteins, triglycerides and concentration of platelet factor-4, β-tromboglobulin, von Willebrand factor in 68 patients with acute ischemic stroke and diabetes mellitus. Authors investigate the dynamics of these parameters (1st, 21st, 3-d and 6th month after onset stroke) depending on timing and dose of Mexidol. Results. Long time therapy of Mexidol may optimize of hypolipidemic therapy in ischemic stroke and diabetes mellitus patients. © 2016, Media Sphera. All rights reserved. Source


Kim L.B.,Research Institute of Experimental and Clinical Medicine | Russkikh G.S.,Research Institute of Experimental and Clinical Medicine | Gevorgian M.M.,Research Institute of Experimental and Clinical Medicine | Putyatina A.N.,Research Institute of Experimental and Clinical Medicine | And 6 more authors.
Human Physiology | Year: 2016

Age-related decrease in blood concentration of testosterone and dehydroepiandrosterone sulfate was found in mining workers living in the European North. The correlation analysis reveals associations of both hormones with biological age and testosterone with plasma lipid profile. The age dependence of cardiovascular risk and the hormonal mechanisms of its development are discussed. © 2016, Pleiades Publishing, Inc. Source


Kozhin P.M.,Research Institute of Experimental and Clinical Medicine | Chechushkov A.V.,Research Institute of Experimental and Clinical Medicine | Zaitseva N.S.,Research Institute of Experimental and Clinical Medicine | Lemza A.E.,Research Institute of Experimental and Clinical Medicine | And 3 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2015

We studied the effects of liposomal pharmaceutical compositions with oxidized dextrans on functional activity of U937 monocyte/macrophage-like cells. Liposomes in the emulsion contained oxidized dextran with a molecular weights of 40 kDa or 70 kDa or isonicotinic acid hydrazide (INAH) conjugated with oxidized dextran (40 kDa). Cell viability was evaluated by MTT test; mitochondrial transmembrane potential and production of superoxide anion and H2O2 were studied by fluorescent methods. The studied compositions exhibited no cytotoxic effect and even improved cell viability and mitochondrial respiration. Liposomes with oxidized 40 kDa dextran, including those with INAH-conjugated dextran, inhibited production of superoxide anion, but increased H2O2 generation. © 2015, Springer Science+Business Media New York. Source

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