Blokhina Research Institute of Epidemiology and Microbiology

Nizhniy Novgorod, Russia

Blokhina Research Institute of Epidemiology and Microbiology

Nizhniy Novgorod, Russia

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Filatova E.N.,Blokhina Research Institute of Epidemiology and Microbiology | Anisenkova E.V.,Blokhina Research Institute of Epidemiology and Microbiology | Presnyakova N.B.,Blokhina Research Institute of Epidemiology and Microbiology | Utkin O.V.,Nizhny Novgorod State Medical Academy
Acta Microbiologica et Immunologica Hungarica | Year: 2016

Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4+ (nTh) and CD8+ (nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM. © 2016 Akadémiai Kiado, Budapest.


Golitsyna L.N.,Blokhina Research Institute of Epidemiology and Microbiology | Zverev V.V.,Blokhina Research Institute of Epidemiology and Microbiology | Novikova N.A.,Blokhina Research Institute of Epidemiology and Microbiology | Fomina S.G.,Blokhina Research Institute of Epidemiology and Microbiology | And 5 more authors.
Voprosy Virusologii | Year: 2013

A total of 5230 specimens from children with gastroenteritis collected in Nizhny Novgorod in 2006-2010 were screened for human parechoviruses (HPeV). HPeV were observed every year with mean frequency of 6.16%. The majority of HpeV (65.83%) was detected In children younger than 3 years. The typing of 71 detected HPeV with the use of partial sequencing of the VP3-VP1 region revealed the presence of HPeV1 (91.55%), HpeV6 (5.63%), HPeV3 (3.08%), HPeV4 (1.54%). HPeV1B was predominant among HPeV1, HPeV1A was identified rarely. Six stains of HPEV1 formed separate phylogenetic cluster, had sequence gomology with HPEV1A or HPeV1B not more than 88% and could be characterized as members of a separate genotype HPeV1.

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