Research Institute of Cardiology

Yerevan, Armenia

Research Institute of Cardiology

Yerevan, Armenia
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Dashdamirov R.L.,Research Institute of Cardiology
Azerbaijan Pharmaceutical and Pharmacotherapy Journal | Year: 2010

The aim of the study was to evaluate the hemodynamic and metabolic effects of moxonidine in hypertensive pts with metabolic syndrome. 60 hypertensive pts with metabolic syndrome, men and women age 36-72(average 56,5+ -10,02)were examined. The result of the study showes mat moxonidine in a dose of 0,4mg/daily, very effectively decrease both systolic and diastolic BP. Also, moxonidine improves intracardiac hemodinamics, positively impact lipids and carbohydrates exchange, improves quality of life. © Rafail L. Daşdinverted e signmirov, 2010.


Maslov L.N.,Research Institute of Cardiology | Vychuzhanova E.A.,Research Institute of Cardiology
Neuroscience and Behavioral Physiology | Year: 2016

Noradrenaline released from sympathetic nerve endings and adrenaline secreted by the adrenal cortex have been shown to play roles in cold adaptation. The calorigenic effect of noradrenaline increases during acclimation. Catecholamines stimulate noncontractile thermogenesis in brown fat tissue, white fat tissue, and skeletal muscle. Adrenergic increases in cold tolerance are associated with increases in UCP expression in the tissues. The following signal pathway operates in mediating the calorigenic effect of catecholamines in prolonged cold exposure: catecholamines → β-adrenergic receptors → adenylate cyclase, cAMP → protein kinase A → p38 kinase → transcription factors → increased UCP expression. The following signal pathway operates on acute exposure to cold: catecholamines → β-adrenergic receptors → adenylate cyclase → cAMP → protein kinase A → hormone-sensitive lipase → free fatty acids → UCP → uncoupling of oxidative phosphorylation. The calorigenic effect of stimulation of α1-adrenoreceptors is mediated by the following mechanism: noradrenaline → α1-adrenergic receptors → phospholipase C → inositol-1,4,5-triphosphate → [Ca2+]i → increased calorigenic effect of catecholamines. © 2016, Springer Science+Business Media New York.


Krivonogov N.G.,Research Institute of Cardiology | Efimova N.Y.,Tomsk Polytechnic University | Zavadovsky K.W.,Tomsk Polytechnic University | Lishmanov Y.B.,Tomsk Polytechnic University
AIP Conference Proceedings | Year: 2016

Ventilation/perfusion lung scintigraphy was performed in 39 patients with verified diagnosis of community-acquired pneumonia (CAP) and in 14 patients with peripheral lung cancer. Ventilation/perfusion ratio, apical-basal gradients of ventilation (U/L(V)) and lung perfusion (U/L(P)), and alveolar capillary permeability of radionuclide aerosol were determined based on scintigraphy data. The study demonstrated that main signs of CAP were increases in ventilation/perfusion ratio, perfusion and ventilation gradient on a side of the diseased lung, and two-side increase in alveolar capillary permeability rate for radionuclide aerosol. Unlike this, scintigraphic signs of peripheral lung cancer comprise an increase in ventilation/perfusion ratio over 1.0 on a side of the diseased lung with its simultaneous decrease on a contralateral side, normal values of perfusion and ventilation gradients of both lungs, and delayed alveolar capillary clearance in the diseased lung compared with the intact lung. © 2016 Author(s).


Maslov L.N.,Research Institute of Cardiology | Mukhomedzyanov A.V.,Research Institute of Cardiology | Sementsov A.S.,Research Institute of Cardiology
Neuroscience and Behavioral Physiology | Year: 2017

High molecular weight peptide(s) operate as the trigger for remote postconditioning (RPC) of the heart. Nitric oxide and adenosine function as mediators between peptide and intracellular structures. The autonomic nervous system does not have a role in RPC. The signal mechanism of RPC involves protein kinase C, PI3 kinase, Akt kinase, and aldehyde dehydrogenase. The hypothetical end effector of RPC is the BKCa channel © 2016, Springer Science+Business Media New York.


Mamchur S.,Research Institute for Complex Issues of Cardiovascular Diseases | Bokhan N.,Research Institute for Complex Issues of Cardiovascular Diseases | Vecherskii Y.,Research Institute of Cardiology | Malyshenko E.,Research Institute for Complex Issues of Cardiovascular Diseases
Seminars in Thoracic and Cardiovascular Surgery | Year: 2015

The objective of the study was to estimate the internal thoracic arteries (ITA) and radial arteries (RA) micromorphologic features by light microscopy after harvesting them using the skeletonization and pedicled methods in patients undergoing coronary artery bypass grafting. The micromorphologic characteristics of ITA and RA were studied by luminous microscopy in 61 patients undergoing coronary artery bypass grafting. A total of 122 ITA and RA segments harvested during surgery, fixed in formalin, and stained with hematoxiline and eosin were evaluated. The mean intima-media thickness of ITA was 9.2 and 134.7. μm and that of RA was 9.1 and 334.2. μm, respectively. In the distal segment of ITA the media-intima relation was 1.5 times bigger than in the proximal segment. None of ITA specimens contained atherosclerotic plaques or lipid inclusions. Atherosclerotic plaques were found in 3 (5%) RA specimens. Other degenerative changes were detected in 30%-74.2% of the specimens: splitting of internal elastic lamina, reduced tortuosity of the internal elastic lamina, and thickening and detachment of the intima; their incidence was associated with the skeletonization of the vessels. In conclusion, the incidence of ITA and RA degenerative changes varies from 30%-74.2% and its increase is associated with the skeletonization of the vessels, which is statistically significant. The media of the RA is 2.5 times thicker than that of the ITA (P < 0.01). This fact shows that RA has higher spasmogenic potential than that of ITA. The distal segment of the ITA has 1.5 times bigger media-intima relation than the proximal segment. Therefore, in case of enough graft length, it is recommended to avoid the distal segment and cut it off. © 2015 Elsevier Inc.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with (99m)Tc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity-time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Experiments on isolated perfused rat heart modeled 45-min global ischemia followed by 30-min reperfusion. Ischemic postconditioning was modeled by 3 cycles of reperfusion (30 sec) and ischemia (30 sec). Cardiomyocyte necrosis was assessed by the level of creatine phosphokinase in the perfusate. Postconditioning reduced the release of creatine phosphokinase from the heart by 30%. The cardioprotective effect of ischemic postconditioning was eliminated after inhibition of protein kinase C with cheleritrin or after blockade of -isoform of protein kinase C with rottlerin. These findings attest to participation of protein kinase C- in the realization of the cardioprotective effect of postconditioning.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Terapevticheskii arkhiv | Year: 2016

to define and develop a procedure that can select patients with resistant hypertension (RH) for a renal sympathetic denervation (RSD) procedure, by being orienting to the specific initial values of -adrenoreactivity (-AR) and systolic blood pressure (SBP).The analysis included 23 RH patients receiving the maximally tolerable doses of 4 antihypertensive drugs. The investigations involving BP control and a Russian spectrophotometric procedure for determining -AR in terms of the change in the osmoresistance of erythrocyte membranes (EM) were performed at baseline and 4 and 24 weeks. RSD was carried out using endovascular radiofrequency ablation of the renal arteries. The therapy was not changed during the observation.If SBP was >170 mm Hg and -AR of EM >40 conditional units (CUs) at baseline, SBP was 17.683.24 mm Hg and the efficiency of RSD was 100%. When SBP was <170 mm Hg and -AR of EM <40 CUs at baseline, SBP was 0.974.21 mm Hg (p>0.05) and the efficiency of RSD was low.The overall estimate of baseline SBP and -AR of EM in patients with RH could determine the expediency of the RSD procedure in order to lower BP. The proposed procedure can optimize the selection of patients and enhance the efficiency of RSD in the treatment of RH.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We studied the effects of -adrenoceptor antagonists propranolol and nadolol and L-type Ca(2+)-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of -adrenoceptors and opening of L-type Ca(2+)-channels promote the development of cardiac reperfusion injury, while blockage of -adrenoceptors and/or L-type Ca(2+)-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.


PubMed | Research Institute of Cardiology
Type: | Journal: Khirurgiia | Year: 2016

To evaluate surgical results in adults with aortic arch interruption.Seven patients with aortic arch interruption were operated. Two of them (28.6%) underwent aortic arch repair using allograft, 4 (57.21%) - distal arch and proximal descending aortic replacement, 1 (14.3%) - supra-coronary ascending aortic, aortic arch and proximal descending aortic replacement. All operations were performed under moderate hypothermia (25 ), circulatory arrest with unilateral cerabral perfusion 8-10 ml/kg/min via innominate artery and pressure 69.614.7 mm Hg in arterial.Cardiopulmonary bypass (CPB) time was 24236.1 min, aortic cross-clamping - 110.740.4 min, circulatory arrest - 58.617.9 min. There were no cases of renal insufficiency, vascular lesion of brain and spinal cord, cardiac events. Resternotomy for bleeding was performed in 1 (14.3%) case. Sufficient descending aortic lumen was achieved in 100% according to CT postoperatively. Peak descending aortic pressure gradient after repair with allograft was 291.4 mm Hg, after aortic replaement - 104.2 mm Hg. Postoperative and in-hospital 30-day mortality was absent.Reconstructive surgery for aortic arch interruption in adults is effective approach with good clinical and hemodynamic results.

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