Research Institute of Cardiology

Yerevan, Armenia

Research Institute of Cardiology

Yerevan, Armenia

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PubMed | Research Institute of Cardiology and PLA Fourth Military Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Selective agonists of


Mamchur S.,Research Institute for Complex Issues of Cardiovascular Diseases | Bokhan N.,Research Institute for Complex Issues of Cardiovascular Diseases | Vecherskii Y.,Research Institute of Cardiology | Malyshenko E.,Research Institute for Complex Issues of Cardiovascular Diseases
Seminars in Thoracic and Cardiovascular Surgery | Year: 2015

The objective of the study was to estimate the internal thoracic arteries (ITA) and radial arteries (RA) micromorphologic features by light microscopy after harvesting them using the skeletonization and pedicled methods in patients undergoing coronary artery bypass grafting. The micromorphologic characteristics of ITA and RA were studied by luminous microscopy in 61 patients undergoing coronary artery bypass grafting. A total of 122 ITA and RA segments harvested during surgery, fixed in formalin, and stained with hematoxiline and eosin were evaluated. The mean intima-media thickness of ITA was 9.2 and 134.7. μm and that of RA was 9.1 and 334.2. μm, respectively. In the distal segment of ITA the media-intima relation was 1.5 times bigger than in the proximal segment. None of ITA specimens contained atherosclerotic plaques or lipid inclusions. Atherosclerotic plaques were found in 3 (5%) RA specimens. Other degenerative changes were detected in 30%-74.2% of the specimens: splitting of internal elastic lamina, reduced tortuosity of the internal elastic lamina, and thickening and detachment of the intima; their incidence was associated with the skeletonization of the vessels. In conclusion, the incidence of ITA and RA degenerative changes varies from 30%-74.2% and its increase is associated with the skeletonization of the vessels, which is statistically significant. The media of the RA is 2.5 times thicker than that of the ITA (P < 0.01). This fact shows that RA has higher spasmogenic potential than that of ITA. The distal segment of the ITA has 1.5 times bigger media-intima relation than the proximal segment. Therefore, in case of enough graft length, it is recommended to avoid the distal segment and cut it off. © 2015 Elsevier Inc.


PubMed | Research Institute of Cardiology and rogov Russian Research Medical University
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N,N-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.190.11 for the central areas and 1.470.17 for the peripheral ones. The pituitary (1.180.05) and vascular plexuses of the lateral ventricles (1.120.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.


Mochula A.V.,Research Institute of Cardiology | Zavadovsky K.V.,Tomsk Polytechnic University | Lishmanov Y.B.,Tomsk Polytechnic University
Bulletin of Experimental Biology and Medicine | Year: 2016

We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations. © 2016 Springer Science+Business Media New York


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with (99m)Tc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity-time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

Experiments on isolated perfused rat heart modeled 45-min global ischemia followed by 30-min reperfusion. Ischemic postconditioning was modeled by 3 cycles of reperfusion (30 sec) and ischemia (30 sec). Cardiomyocyte necrosis was assessed by the level of creatine phosphokinase in the perfusate. Postconditioning reduced the release of creatine phosphokinase from the heart by 30%. The cardioprotective effect of ischemic postconditioning was eliminated after inhibition of protein kinase C with cheleritrin or after blockade of -isoform of protein kinase C with rottlerin. These findings attest to participation of protein kinase C- in the realization of the cardioprotective effect of postconditioning.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Terapevticheskii arkhiv | Year: 2016

to define and develop a procedure that can select patients with resistant hypertension (RH) for a renal sympathetic denervation (RSD) procedure, by being orienting to the specific initial values of -adrenoreactivity (-AR) and systolic blood pressure (SBP).The analysis included 23 RH patients receiving the maximally tolerable doses of 4 antihypertensive drugs. The investigations involving BP control and a Russian spectrophotometric procedure for determining -AR in terms of the change in the osmoresistance of erythrocyte membranes (EM) were performed at baseline and 4 and 24 weeks. RSD was carried out using endovascular radiofrequency ablation of the renal arteries. The therapy was not changed during the observation.If SBP was >170 mm Hg and -AR of EM >40 conditional units (CUs) at baseline, SBP was 17.683.24 mm Hg and the efficiency of RSD was 100%. When SBP was <170 mm Hg and -AR of EM <40 CUs at baseline, SBP was 0.974.21 mm Hg (p>0.05) and the efficiency of RSD was low.The overall estimate of baseline SBP and -AR of EM in patients with RH could determine the expediency of the RSD procedure in order to lower BP. The proposed procedure can optimize the selection of patients and enhance the efficiency of RSD in the treatment of RH.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Terapevticheskii arkhiv | Year: 2016

to investigate the specific features and results of percutaneous interventions (PCI) into the coronary arteries in patients with acute ST-segment elevation myocardial infarction (MI) and diabetes mellitus (DM) in clinical practice.A study group consisted of 120 patients with a history of type 2 DM, who had undergone primary PCI in 2008 to 2013. A comparison group included 601 patients without a history of DM.Assessment of the results of hospital interventions revealed no differences between the study and comparison groups in mortality rates (4.1 and 3.2%, respectively; p=0.376), stent thromboses (0.8 and 1.2%, respectively; p=0.601), and recurrent MI (0 and 1.5%, respectively; p=0.189). No differences were determined in the combined index including death, recurrent MI, and stent thrombosis (5 and 5%; p=0.985). At the same time, the no-reflow phenomenon developed statistically significantly more frequently in the patients with DM (7.4 and 2.8%; p=0.019). Binary logistic regression established independent associations between the presence of DM and patient age (odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02 to 1.07; p<0.001), female sex (OR 0.36; 95% CI 0.23 to 0.56; p<0.001), and higher body mass index (OR 1.1; 95% CI 1.06 to 1.16; p<0.04).Primary PCIs in patients with DM are an effective and safe method for revascularization in acute ST-segment elevation MI and these are not followed by increases in mortality and frequency of major poor cardiac complications at the hospital stage despite the more common development of the no-reflow phenomenon.


PubMed | Research Institute of Cardiology
Type: Journal Article | Journal: Bulletin of experimental biology and medicine | Year: 2016

We studied the effects of -adrenoceptor antagonists propranolol and nadolol and L-type Ca(2+)-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of -adrenoceptors and opening of L-type Ca(2+)-channels promote the development of cardiac reperfusion injury, while blockage of -adrenoceptors and/or L-type Ca(2+)-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.


PubMed | Research Institute of Cardiology
Type: | Journal: Khirurgiia | Year: 2016

To evaluate surgical results in adults with aortic arch interruption.Seven patients with aortic arch interruption were operated. Two of them (28.6%) underwent aortic arch repair using allograft, 4 (57.21%) - distal arch and proximal descending aortic replacement, 1 (14.3%) - supra-coronary ascending aortic, aortic arch and proximal descending aortic replacement. All operations were performed under moderate hypothermia (25 ), circulatory arrest with unilateral cerabral perfusion 8-10 ml/kg/min via innominate artery and pressure 69.614.7 mm Hg in arterial.Cardiopulmonary bypass (CPB) time was 24236.1 min, aortic cross-clamping - 110.740.4 min, circulatory arrest - 58.617.9 min. There were no cases of renal insufficiency, vascular lesion of brain and spinal cord, cardiac events. Resternotomy for bleeding was performed in 1 (14.3%) case. Sufficient descending aortic lumen was achieved in 100% according to CT postoperatively. Peak descending aortic pressure gradient after repair with allograft was 291.4 mm Hg, after aortic replaement - 104.2 mm Hg. Postoperative and in-hospital 30-day mortality was absent.Reconstructive surgery for aortic arch interruption in adults is effective approach with good clinical and hemodynamic results.

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