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Hovhannisyan S.G.,Research Institute of Cardiology | Muradyan N.A.,Yerevan State Medical University | Arshamyan A.Z.,Yerevan State Medical University
New Armenian Medical Journal | Year: 2012

High blood pressure is a major global chronic non-communicable disease and modifiable risk factor for cardiovascular diseases. The World Health Report 2002 identified hypertension as one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide and the third ranked factor for disability-adjusted life years. It is predicted that the burden of hypertension would increase approximately to 1.56 billion in the year 2025. The absolute prevalence of hypertension in economically developed nations is ~37.3% compared with 22.9% in developing nations. However, the studies conducted among the rural population are not numerous in Armenia. Therefore, the purpose of this article was to review data on high blood pressure prevalence in several villages of Armenia. The cross-sectional study was conducted in rural population during 33 days (between September and October 2009); adults 20 years of age and over were considered appropriate. A total of 1,094 adults (64% females) were surveyed. The prevalence of hypertension made 39% and 20% in the Gegharkunik and Kotayk marzes (regions), respectively. In Gegharkunik marz high blood pressure was more frequent in males than in females: 44.5% vs. 36.4%, but in Kotayk marz high blood pressure was more frequent in females than in males: 63.5% vs. 36.5% (p≤0.05 in all cases). The prevalence of high blood pressure increases with age. Like every other country in the world, the prevalence of high blood pressure among the rural population is an actual problem in Armenia. Hence, it is necessary to study the risk factors for high blood pressure affecting its prevalence.

Mamchur S.,Research Institute for Complex Issues of Cardiovascular Diseases | Bokhan N.,Research Institute for Complex Issues of Cardiovascular Diseases | Vecherskii Y.,Research Institute of Cardiology | Malyshenko E.,Research Institute for Complex Issues of Cardiovascular Diseases
Seminars in Thoracic and Cardiovascular Surgery | Year: 2015

The objective of the study was to estimate the internal thoracic arteries (ITA) and radial arteries (RA) micromorphologic features by light microscopy after harvesting them using the skeletonization and pedicled methods in patients undergoing coronary artery bypass grafting. The micromorphologic characteristics of ITA and RA were studied by luminous microscopy in 61 patients undergoing coronary artery bypass grafting. A total of 122 ITA and RA segments harvested during surgery, fixed in formalin, and stained with hematoxiline and eosin were evaluated. The mean intima-media thickness of ITA was 9.2 and 134.7. μm and that of RA was 9.1 and 334.2. μm, respectively. In the distal segment of ITA the media-intima relation was 1.5 times bigger than in the proximal segment. None of ITA specimens contained atherosclerotic plaques or lipid inclusions. Atherosclerotic plaques were found in 3 (5%) RA specimens. Other degenerative changes were detected in 30%-74.2% of the specimens: splitting of internal elastic lamina, reduced tortuosity of the internal elastic lamina, and thickening and detachment of the intima; their incidence was associated with the skeletonization of the vessels. In conclusion, the incidence of ITA and RA degenerative changes varies from 30%-74.2% and its increase is associated with the skeletonization of the vessels, which is statistically significant. The media of the RA is 2.5 times thicker than that of the ITA (P < 0.01). This fact shows that RA has higher spasmogenic potential than that of ITA. The distal segment of the ITA has 1.5 times bigger media-intima relation than the proximal segment. Therefore, in case of enough graft length, it is recommended to avoid the distal segment and cut it off. © 2015 Elsevier Inc.

Varlamova N.V.,Tomsk Polytechnic University | Skuridin V.S.,Tomsk Polytechnic University | Sazonov A.E.,Moscow State University | Sazonova S.I.,Research Institute of Cardiology | And 2 more authors.
Key Engineering Materials | Year: 2016

Investigations have been carried out into creation of reagent for 99mTc-labeled norfloxacin hydrochloride (NFH). The NFH synthesized in the Institute of Organic Synthesis (Ekaterinburg, Russia) was used in this research. The effect of the mixture components on the radiochemical specimen purity was assessed using the method of thin-layer chromatography. The inflammation animal model was used to demonstrate the NFH functional eligibility for diagnostics of inflammatory processes. © 2016 Trans Tech Publications, Switzerland.

Mochula A.V.,Research Institute of Cardiology | Zavadovsky K.V.,Tomsk Polytechnic University | Lishmanov Y.B.,Tomsk Polytechnic University
Bulletin of Experimental Biology and Medicine | Year: 2016

We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with 99mTc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity–time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations. © 2016 Springer Science+Business Media New York

Lasukova T.V.,Tomsk State Pedagogical University | Maslov L.N.,Research Institute of Cardiology | Gorbunov A.S.,Research Institute of Cardiology
Bulletin of Experimental Biology and Medicine | Year: 2015

We studied the effects of μ-opioid receptor activation in vivo and in vitro on the tolerance of isolated perfused rat heart to global ischemia (45 min) and reperfusion (30 min). Stimulation of μ-receptors in vivo by intraperitoneal administration of μ-opioid receptor agonist DAMGO (0.1 mg/kg) reduced reperfusion release of creatinine phosphokinase and promoted aggravation of postischemic systolic and diastolic dysfunction of the isolated heart. Activation of μ-opioid receptors in vitro by addition of selective agonist DAMGO in a concentration of 170 nM to perfusion solution had no effect on necrotic death of cardiomyocytes and aggravated reperfusion stunning of the heart. © 2015, Springer Science+Business Media New York.

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