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Jamadagni S.B.,Research Institute of Ayurvedic Drug Development | Jamadagni P.S.,Research Institute of Ayurvedic Drug Development | Upadhyay S.N.,Research Institute of Ayurvedic Drug Development | Gaidhani S.N.,Research Institute of Ayurvedic Drug Development | Hazra J.,Research Institute of Ayurvedic Drug Development
Toxicologic Pathology | Year: 2011

A unilateral non-metastatic embryonal carcinoma and teratoma of the testis was observed in a 12-week-old Swiss Albino mouse at the end of a 28-day repeated dose toxicity study. The teratocarcinoma almost completely replaced the parenchyma of the left testis. The tumor was composed of sheets and rosettes of primitive embryonal cells, anaplastic cells, skeletal muscle tissue, sebaceous gland tissue, keratinized stratified squamous epithelium, and ciliated cuboidal epithelium. The histomorphological characteristics of the tumor were reviewed and presented in this report. To the best of the authors' knowledge, this is the first report of spontaneous teratocarcinoma of testis in the Swiss Albino strain of mice. © 2011 by The Author(s). Source

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