Oasi Research Institute Irccs

Troina, Italy

Oasi Research Institute Irccs

Troina, Italy
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Chamorro R.,University of Chile | Ferri R.,OASI Research Institute IRCCS | Algarin C.,University of Chile | Garrido M.,University of Chile | And 2 more authors.
Sleep | Year: 2014

Study Objectives: To compare sleep microstructure (cyclic alternating pattern, CAP) characteristics in otherwise healthy overweight (OW) and normal weight (NW) children Design: Polysomnographic cross-sectional study Setting: Sleep laboratory Participants: Fifty-eight (26 NW and 32 OW) 10-year-old children Interventions: N/A Measurements and Results: Participants were part of a longitudinal study beginning in infancy and free of sleep disorders. Groups were based on body-mass index (BMI) z-score. From polysomnographic overnight recordings, sleep-waking states were scored according to international criteria. CAP analysis was performed visually during NREM sleep. Conventional sleep parameters were similar between groups. BMI was positively related to CAP rate and CAP sequences but inversely related to CAP B phase duration. Differences between groups were confined to slow-wave sleep (SWS), with OW children showing higher CAP rate, CAP cycles, and CAP A1 number and index and shorter CAP cycles and B phase duration. They also showed more CAP class intervals shorter than 30 s, and a suggestive trend for fewer intervals longer than 30 s. Conclusions: Cyclic alternating pattern characteristics in children related to nutritional status and were altered in overweight subjects during slow-wave sleep. We suggest that the more frequent oscillatory pattern of electroencephalographic slow activity in overweight subjects might reflect less stable slow-wave sleep episodes.


Peirano P.,University of Chile | Algarin C.,University of Chile | Chamorro R.,University of Chile | Manconi M.,Civic Hospital EOC of Lugano | And 2 more authors.
Sleep Medicine | Year: 2012

Objectives: To explore the eventual connection between iron deficiency anemia (IDA) in infancy and altered leg movements during sleep in a 10-year follow-up study in children who did or did not have IDA in infancy.Subjects and methods: Polysomnographic studies were performed in 32 10-year-old children (13 females and 19 males) who had IDA in infancy and 26 peers (10 females and 16 males) who were nonanemic controls. The time structure of their polysomnographically recorded leg movements (LM) was analyzed by means of an approach particularly able to consider their quantity, periodicity, and distribution during the night.Results: All LM indexes and those related to periodic LM during sleep (PLMS) were slightly higher in the former IDA group than in the control group, but not always significant. The Periodicity index during NREM sleep was higher and was reflected by a small but significant increase in PLMS separated by 10-50. s intervals. PLMS index tended to be higher in former IDA children than in controls throughout the whole night.Conclusion: The association between IDA in infancy, despite iron therapy, and PLMS in childhood could lead to new research in this area. Indeed, transient infantile IDA, a common nutritional problem among human infants, may turn out to be important for understanding the mechanisms of PLMS or restless legs syndrome, which are common in adulthood. © 2012.


Salminen A.V.,University of Tampere | Salminen A.V.,Unesta Research Center | Manconi M.,Civic Hospital of Lugano | Rimpila V.,University of Tampere | And 7 more authors.
Journal of Clinical Sleep Medicine | Year: 2013

Objective: In this study we examine the temporal connection between periodic leg movements (PLMs) and cortical arousals, as well as the treatment effect of pramipexole, in a clinical case with spinal cord lesion. Methods: A patient with complete cervical spinal cord injury and PLMs during sleep underwent two baseline sleep recordings, one recording with dopaminergic treatment, and one recording with adaptive servoventilation. Results: The PLMs were temporally dissociated from cortical arousals as well as from respiratory or heart rate events. PLMs were suppressed by pramipexole and persisted after treatment of apnea. Conclusion: The disconnection of PLMs from arousals supports a spinal generator or peripheral trigger mechanism for PLMs. The suppression of movements by a dopamine agonist suggests that its site of action is caudal to the cervical lesion and outside of the brain. Our observation provides significant new knowledge about the pathogenesis of PLMs and warrants studies in larger populations.


Dosi C.,University of Rome La Sapienza | Figura M.,Messina University | Figura M.,Oasi Research Institute IRCCS | Ferri R.,Oasi Research Institute IRCCS | Bruni O.,University of Rome La Sapienza
Seminars in Pediatric Neurology | Year: 2015

The interaction between sleep and headache or migraine is powerful and an elevated comorbidity between these 2 disorders has been reported in either adults or children. This comobidity is linked to common neurophysiological and neuroanatomical substrates that are genetically based strongly. The first reports on this relationship were related to the prevalence of parasomnias and sleep-disordered breathing in headache but recent research has expanded the comorbidity to several other sleep disorders, such as restless legs syndrome, periodic limb movements during sleep, and narcolepsy. The assessment of children with headache should always include an accurate anamnesis for the presence of sleep problems either in the child or in the relatives; no correct approach for treating children and adolescents is possible without an integrated method of evaluation and management. © 2015 Elsevier Inc.


PubMed | University of Rome La Sapienza, Messina University and Oasi Research Institute IRCCS
Type: Journal Article | Journal: Seminars in pediatric neurology | Year: 2015

The interaction between sleep and headache or migraine is powerful and an elevated comorbidity between these 2 disorders has been reported in either adults or children. This comobidity is linked to common neurophysiological and neuroanatomical substrates that are genetically based strongly. The first reports on this relationship were related to the prevalence of parasomnias and sleep-disordered breathing in headache but recent research has expanded the comorbidity to several other sleep disorders, such as restless legs syndrome, periodic limb movements during sleep, and narcolepsy. The assessment of children with headache should always include an accurate anamnesis for the presence of sleep problems either in the child or in the relatives; no correct approach for treating children and adolescents is possible without an integrated method of evaluation and management.


Amato C.,Oasi Research Institute Irccs | Elia M.,Oasi Research Institute Irccs
Neuroradiology Journal | Year: 2012

In neuro-Behçet's disease nervous involvement may occasionally precede somatic manifestations, making the diagnosis challenging. The reported case showed only a neurologic onset with relapsing-remitting form, transient brain MRI abnormalities and late appearance of typical muco-cutaneous lesions, thereby delaying the correct diagnosis and appropriate treatment. MRI revealed cerebral alterations mimicking demyelinating disease, but lesions rapidly disappeared on close follow-up scans indicating vasogenic edema. Being aware of this atypical presentation and recognizing these transient abnormalities may be useful for a prompt diagnosis.


PubMed | Oasi Research Institute Irccs
Type: Journal Article | Journal: The neuroradiology journal | Year: 2013

In neuro-Behets disease nervous involvement may occasionally precede somatic manifestations, making the diagnosis challenging. The reported case showed only a neurologic onset with relapsing-remitting form, transient brain MRI abnormalities and late appearance of typical muco-cutaneous lesions, thereby delaying the correct diagnosis and appropriate treatment. MRI revealed cerebral alterations mimicking demyelinating disease, but lesions rapidly disappeared on close follow-up scans indicating vasogenic edema. Being aware of this atypical presentation and recognizing these transient abnormalities may be useful for a prompt diagnosis.

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