Research Institute i12

Madrid, Spain

Research Institute i12

Madrid, Spain
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Fiuza-Luces C.,European University at Madrid | Fiuza-Luces C.,Research Institute i12 | Soares-Miranda L.,University of Porto | Gonzalez-Murillo A.,Jesus University | And 8 more authors.
Medicine and Science in Sports and Exercise | Year: 2013

INTRODUCTION: Chronic graft versus host disease (cGVHD) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation that generates considerable morbidity and compromises the physical capacity of patients. We determined the effects of an exercise training program performed after allogeneic hematopoietic stem cell transplantation on clinical and biological variables in a minor histocompatibility antigen-driven murine model of cGVHD treated with cyclosporine A. METHODS: Recipient BALB/C female mice (age 8 wk) received bone marrow cells and splenocytes from donor B10.D2 male mice and were randomly assigned to an exercise (n = 11) or control group (n = 12). For approximately 11 wk after transplant, the exercise group completed a moderate-intensity treadmill program. Variables assessed were clinical severity scores, survival, physical fitness, cytokine profile, immune cell reconstitution, molecular markers of muscle exercise adaptations, and histological scores in affected tissues. RESULTS: Exercise training increased survival (P = 0.011), diminished total clinical severity scores (P = 0.002), improved physical fitness (P = 0.030), and reduced blood IL-4 and tumor necrosis factor α levels (P = 0.03), while increasing circulating B220 (P = 0.008) and CD4 lymphocytes (P = 0.043). CONCLUSIONS: A moderate-intensity exercise program that mimics widely accepted public health recommendations for physical activity in human adults was well tolerated and positive effects on survival as well as on clinical and biological indicators of cGVHD. Copyright © 2013 by the American College of Sports Medicine.


Perez M.,European University at Madrid | Groeneveld I.F.,Rijnlands Rehabilitation Center | Santana-Sosa E.,European University at Madrid | Fiuza-Luces C.,European University at Madrid | And 6 more authors.
Pediatric Pulmonology | Year: 2014

Background Children with cystic fibrosis (CF) often have to be hospitalized because of acute exacerbation of their respiratory symptoms. Given the fact that improved peak oxygen uptake (VO2peak) is positively associated with lung function and overall health in children with CF, this study examined the association between VO2peak and the need for hospitalization in a cohort of pediatric CF patients. Methods In a 3-year study, 77 CF children with mild-to-moderately severe CF (forced expiratory volume in 1-sec [FEV 1]-≥-50%) underwent a maximal exercise test to determine VO 2peak. Anthropometric, lung function and muscle strength measurements were also conducted and dates of hospitalization were recorded for the study period. Associations were then determined between the variables recorded and hospitalization by univariate and multivariate Cox proportional hazards regression analyses. Results VO2peak was 38.6-±-6.7-ml-kg -1-min-1 for boys and 31.9-±-6.9-ml-kg -1-min-1 for girls. In multivariate analyses, VO 2peak was the only variable significantly associated with time to hospitalization (hazard ratio 0.91, P-=-0.03). Conclusion A significant association was detected between greater aerobic fitness, and lower risk of hospitalization. Because hospitalization due to respiratory exacerbation is a powerful prognostic factor, our findings provide further support for the importance of aerobic fitness evaluation in the management of children with mild-to-moderately severe CF. © 2013 Wiley Periodicals, Inc.

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