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Altarev S.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases | Barbarash O.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases
Kardiologiya | Year: 2014

The number of patients with coronary artery disease undergoing percutaneous coronary interventions (PCI with stenting is growing. Stenting is associated with dual antiplatelet given until endothelization of stent. In some clinical situations surgery is required, e.g. coronary bypass, before stent is endothelized or soon after acute coronary syndrome, while even short-time antiplatelet therapy cessation might result in fatal sequelae. Nevertheless, before major surgeries, including coronary artery bypass surgery, antiplatelets (particulary thyenopyridines and ticagrelor) sometimes need to be stopped and bridging therapy with short-acting antithrombotics started. The article reviews data on bridging therapy before coronary bypass surgery. Source


Berns S.A.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases | Shmidt E.A.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases | Yuchno E.S.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases | Nagirnyak O.A.,FSBI Research Institute for Complex Issues of Cardiovascular Diseases | And 2 more authors.
Kardiologiya | Year: 2015

We studied relationship between markers of endothelial dysfunction and multifocal atherosclerosis and adverse coronary events in 82 patients with non-ST segment elevation acute coronary syndrome (NSTEACS). Eighteen patients (21.9%) had adverse events during one year of observation. Patients with adverse coronary events had impaired vasodilatory, vasoconstrictive, and adhesive endothelial function. Predictors of unfavorable prognosis in NSTEACS were signs of impaired endothelium-dependent vasodilation during test with reactive hyperemia, high soluble platelet selectin and endothelin-1 levels on day 10 of the disease. Endothelin-1 and soluble platelet-endothelial cell adhesion molecule-1 had greatest predictive power relative to development of non-fatal myocardial infarction. Source

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