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Barbarash O.L.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Usoltseva E.N.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Kashtalap V.V.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Kolomytseva I.S.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | And 3 more authors.
Kardiologiya | Year: 2013

Aim of the study was to determine association between clinical-anamnestic factors and degree of progression of atherosclerotic process in magistral noncocronary arteries during one year after ST-elevation (STE) myocardial infarction (Ml). Material. We included into this study 168 men (mean age 59.5 years) with STEMI subjected during hospitalization to coronary angiography and duplex color scanning of brachiocephalic arteries and main arteries of lower extremities. In a year we performed repeat ultrasound examination of same noncoronary arteries and assessed development of vascular complications. Results. Greatest degree of atherosclerosis progression in noncoronary arteries was registered in patients older than 60 years, with hypertension, presence of atherosclerotic stenoses in noncoronary vascular beds at initial examination, those who had undergone percutaneous coronary intervention or coronary artery bypass grafting, and patients with higher levels of total and low density lipoprotein cholesterol at examination after 12 months post Ml.


Pecherina T.B.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Gruzdeva O.V.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Kashtalap V.V.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Barbarash O.L.,Research Institute for Complex Issues of Cardiovascular Diseases of SB
Kardiologiya | Year: 2013

Aim of the study was to investigate role of matrix metalloproteinases (MMP) in assessment of prognosis of repetitive cardiovascular events during hospital stay of patients with ST-elevation (STE) myocardial infarction (MI). We consecutively included into this study 175 patients with diagnosis of STEM). Content of MMP-1, MMP-3 and MMP-9 in blood serum was measured at admission and on day 12 after onset of disease. Levels of all MMPs on day 12 were 1. 1-1. 6 times higher than on day 1 of Ml (p<0. 05). Comparison of groups of patients with favorable and unfavorable outcome showed that patients with unfavorable outcome had higher median concentrations of MMP-3 and MMP-9 on day 1; this tendency was maintained on day 12. However these differences were significant only for MMP-9. Compared with patients with favorable outcome levels of this marker in patients with unfavorable outcome were higher by 19. 4% (p=0. 04) on day 1 and by 48. 8% (p=0. 03) on day 12. At logistic regression analysis for MMP-9 and unfavorable outcomes during hospital stay area under ROC-curve did not exceed 0. 5. But when only inhospital deaths were considered χ2 MMP-9 (day 1) was 14. 3 (p<0. 0001) while area under ROC-curve was 0. 72 (0. 64; 0. 78; p=0. 02). Thus in patients with STEMI high concentrations of MMP-9 on day 1 of STEMI can come forward as independent marker of unfavorable outcome during hospital stay.


Bairakova Yu.V.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Bazdyrev E.D.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Kazachek Ya.V.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | Kalichenko N.A.,Research Institute for Complex Issues of Cardiovascular Diseases of SB | And 4 more authors.
Kardiologiya | Year: 2013

Aim of the study was to assess prognostic role of high sensitivity C-reactive protein (CRP) in progression of atherosclerosis in patients with ischemic heart disease (IHD) in a year after coronary artery bypass grafting (CABG). We examined 49 patients with stable IHD subjected to elective CABG (45 with and 4 without without cardiopulmonary bypass). In a year after surgery patients were divided into 2 groups: with (group 1, n=18, 36. 7%) and without (group 2, n=31, 63. 3%) progression of atherosclerosis of any localization. Contribution of various clinical and instrumental factors, type of intervention, CRP level before and in 1 year after surgery was analyzed. Before CABS CRP level was 3 times higher in group 1 compared with group 2 (p=0. 03). Increase of intima-media thickness was registered in a year after CABS in both groups, but it was significant only in patients with atherosclerosis progression (p=0. 04). Other clinical factors, gender characteristics of groups, type of intervention exerted no significant influence on progression of systemic atherosclerosis.

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