Research Hospital of Ministry of Health

Ankara, Turkey

Research Hospital of Ministry of Health

Ankara, Turkey
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Ellidag H.Y.,Research Hospital of Ministry of Health | Erdogan N.,Research Hospital of Ministry of Health | Ture S.,Research Hospital of Ministry of Health | Yilmaz N.,Research Hospital of Ministry of Health
Annals of Neurosciences | Year: 2013

Background: The correlation of oligoclonal bands (OCBs) and intrathecal IgG synthesis are not yet clear in multiple sclerosis (MS). Purpose: In this study, we investigated the OCB situation and IgG index, cranial and cervical magnetic resonance imaging (MRI) findings and also compared visual evoked potentials (VEP) and somatosensorial evoked potentials (SEP) in order to better understand the OCB pattern and pathogenesis. Methods: Retrospective study included 40 patients (19 male, 21 female, mean age 29 ± 4,24) with precise MS diagnosis according to McDonald criteria. Result: Sixteen of the patients were OCB negative, and 24 patients were positive. The different between the OCB situation and number of plaques in cranial and cervical MRI, atrophy, oedema and contrast material retention were insignificant. The different between the OCB situation and VEP and SEP were insignificant. Conclusion: These laboratory findings are all specific, all developing via independent mechanisms and are not related to each other during the silence periods of patients.


Yilmaz N.,Research Hospital of Ministry of Health | Aydin O.,Research Hospital of Ministry of Health
Open Biochemistry Journal | Year: 2012

Plasma high-density lipoprotein cholesterol(HDL-C) levels do not predict functionality and composition of high-density lipoprotein(HDL). Traditionally, keeping levels of low-density lipoprotein cholesterol(LDL-C) down and HDL-C up have been the goal of patients to prevent atherosclerosis that can lead to coronary vascular disease(CVD). Peo-ple think about the HDL present in their cholesterol test, but not about its functional capability. Up to 65% of cardiovascular death cannot be prevented by putative LDL-C lowering agents. It well explains the strong in-terest in HDL increasing strategies. However, recent studies have questioned the good in using drugs to increase level of HDL. While raising HDL is a theoretically attractive target, the optimal approach remains uncertain. The attention has turned to the quality, rather than the quantity, of HDL-C. An alternative to elevations in HDL involves strategies to en-hance HDL functionality. The situation poses an opportunity for clinical chemists to take the lead in the development and validation of such bio-markers. The best known function of HDL is the capacity to promote cellular cholesterol efflux from peripheral cells and deliver cholesterol to the liver for excretion, thereby playing a key role in reverse cholesterol transport (RCT). The func-tions of HDL that have recently attracted attention include anti-inflammatory and anti-oxidant activities. High antioxidant and anti-inflammatory activities of HDL are associated with protection from CVD. This review addresses the current state of knowledge regarding assays of HDL functions and their relationship to CVD. HDL as a therapeutic target is the new frontier with huge potential for positive public health implications. © Eren et al.; Licensee Bentham Open.


Ellidag H.Y.,Research Hospital of Ministry of Health | Aydin O.,Research Hospital of Ministry of Health | Akgol E.,Izmir Ataturk Education and Training Hospital | Yalcinkaya S.,Research Hospital of Ministry of Health | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.


Akkoc Y.,Ege University | Ersoz M.,Research Hospital of Ministry of Health | Yldz N.,Pamukkale University | Erhan B.,Istanbul Physical Therapy and Rehabilitation Training and Research Hospital | And 15 more authors.
Spinal Cord | Year: 2013

Study design:Multi-center, cross-sectional study.Objectives:To investigate the effects of different bladder management methods on the quality of life (QoL) in patients with spinal cord injury (SCI).Setting:Turkey.Methods:Consecutive SCI patients (n=195, 74.4% males), for whom at least 6 months had elapsed since the injury, were included and evaluated in five groups: normal spontaneous micturition (NSM), micturition with assisted maneuvers (MAM), aseptic intermittent catheterization by patient (IC-P), aseptic IC by an attendant/caregiver (IC-A) and indwelling catheterization. The King's Health Questionnaire was used to evaluate the patients' QoL.Results:The bladder management groups were similar regarding age, time elapsed since injury, education level, marital and occupational status. There was no difference among the groups in general health perception, personal relationships and sleep/energy domain scores. While the NSM group had generally the lowest scores, that is, better QoL, the IC-A group had the highest scores, that is, poorer QoL, in most of the domains. When the patients were grouped according to the frequency of urinary incontinence or American Spinal Injury Association Impairment Scale grades, no difference was found in the domain scores of the groups except the symptom severity domain scores. No significant difference was found between paraplegic and tetraplegic patients in the King's Health Questionnaire domains.Conclusion:The QoL was notably affected in SCI patients in IC-A group and negative effects on emotional status, physical and social activity limitations were observed, as well. © 2013 International Spinal Cord Society All rights reserved.


Ellidag H.Y.,Research Hospital of Ministry of Health | Cekin Y.,Research Hospital of Ministry of Health | Ayoglu R.U.,Research Hospital of Ministry of Health | Sekercioglu A.O.,Research Hospital of Ministry of Health | Yilmaz N.,Research Hospital of Ministry of Health
Redox Report | Year: 2014

Objectives: Endothelia, intima, and connective tissues comprise the heart valves, but the relationship between heart valve damage, the pathogenesis of valve degeneration, and vitamin D, oxidative stress remains unclear. Here, we assessed serum 25(OH) vitamin D (calcidiol), parathormone (PTH), and redox balance in patients with mitral valve regurgitation (MR) and aortic valve regurgitation (AR). Methods: This study includes 56 chronic heart valve disease (HVD) patients. Patients were diagnosed with MR or AR depending on the echocardiographic findings. Also, 40 sex-matched healthy control participants were enrolled for comparison. Serum calcidiol, PTH, total oxidative status (TOS), and total antioxidative capacity were measured, and the oxidative stress index (OSI) was calculated. Results: Patients with HVD demonstrated significantly higher PTH, increased TOS and OSI, and a higher frequency of calcidiol deficiency than the control participants. Calcidiol and TOS were negatively correlated (r = -0.29; P <0.005), as were calcidiol and OSI (r = -0.413; P = 0.001). PTH and OSI were positively correlated (r = 0.22; P = 0.02). Discussion: We demonstrate that vitamin D deficiency and secondary increases in PTH are highly prevalent. Heart valve regurgitation (AR and MR) is correlated to oxidative stress and hypovitaminosis D. © W. S. Maney & Son Ltd 2014.


Ellidag H.Y.,Research Hospital of Ministry of Health | Yilmaz N.,Research Hospital of Ministry of Health | Cekin Y.,Research Hospital of Ministry of Health
Redox Report | Year: 2014

Objectives: Knowledge about the role of oxidative stress in human diseases, including cardiovascular system disorders, emphasizes the need for reliable markers of oxidative stress. Here, we evaluated the levels of the novel marker ischemia-modified albumin (IMA), albumin-adjusted IMA (adj-IMA), and the IMA/serum albumin ratio (IMAR) in patients with chronic ischemic heart failure (CIHF). Methods: A total of 55 patients with CIHF and 40 age- and sex-matched healthy individuals were included in the study. Serum levels of IMA, total antioxidant status, and total oxidant status were analyzed, and the adj- IMA level, IMAR, and oxidative stress index were calculated. Results: Serum IMA, IMAR, total oxidant status levels, and oxidative stress index were significantly higher in patients with CIHF than in the controls (all P < 0.0001), whereas albumin and total antioxidant status levels were significantly lower in the CIHF patients (P < 0.0001 and P = 0.0004, respectively). However, there was no significant difference in serum adj-IMA levels between the groups (P = 0.8). Discussion: We observed impaired oxidant/antioxidant status in favor of oxidative stress in CIHF patients. Oxidative stress may be a key factor in the development of hypoalbuminemia in CIHF. Further studies are needed to establish the relationships among IMA, albumin, and redox balance in CIHF. © W. S. Maney & Son Ltd 2014.


Yasar Ellidag H.,Research Hospital of Ministry of Health | Ylmaz A.,Research Hospital of Ministry of Health | Aydn O.,Maternity And Childrens Hospital | Ylmaz N.,Research Hospital of Ministry of Health
Open Biochemistry Journal | Year: 2014

We aimed to investigate the relation between serum inflammatory markers, 25OHvit-D3 and oxidative stress markers, namely paraoxonase1-arylesterase (PON1-ARE), total antioxidant status (TAS) and total oxidant status (TOS) in 30 male patients with ST–elevation myocardial infarction(STEMI). There was negative correlation between tumor necrosis factor alpha and ARE; positive correlations between serum amyloid A(SAA) and oxidative stress index, SAA and TOS, 25OHvit-D3 and ARE. There was no statistically significant correlation between inflammation makers, oxidative stress markers and Gensini score. The main finding of our study was the tendency of inflammation markers, and oxidative stress markers, to change in relatively clear opposite directions in STEMI. © Erenet al


Ozdolap S.,Bülent Ecevit University | Emre U.,Bülent Ecevit University | Karamercan A.,Research Hospital of Ministry of Health | Sarikaya S.,Bülent Ecevit University | Kokturk F.,Bülent Ecevit University
American Journal of Industrial Medicine | Year: 2013

Background: It is well-known that work-related upper limb musculoskeletal disorders, particularly tendinitis and nerve entrapment, remain a difficult and costly problem in industrialized countries. The aim of this study was to evaluate tendinitis and entrapment neuropathy of the upper limb of Turkish coal miners. Methods: Eighty coal miners and 43 age-matched clerical workers were included in the study. The evaluation procedures included collection of personal and clinical data, physical examination and bilateral electrodiagnostic testing. Subjects were examined to diagnose tendinitis and nerve entrapment of the upper limb. Bilateral median and ulnar nerves conduction tests were performed on all subjects. Data were collected between August 2011 and December 2011. Results: There were 33 subjects with lateral epicondylitis, 10 with medial epicondylitis, and 22 with De Quervain's disease among the coal miners. There were seven subjects with lateral epicondylitis, eight with medial epicondylitis, and four with De Quervain's disease in the control group. The two groups significantly differed in the prevalences of lateral epicondylitis and De Quervain's disease (P=0.024 and P=0.029, respectively). Sixteen subjects in the coal miners and 12 subjects in the controls had carpal tunnel syndrome (P=0.66). Thirty-seven subjects in the coal miners had ulnar neuropathy of the elbow (UNE), while four subjects in the controls had UNE; this difference was statistically significant (P<0.001). Conclusion: Lateral epicondylitis, De Quervain disease, and ulnar neuropathy are common work-related upper limb disorders among coal miners. Am. J. Ind. Med. 56:569-575, 2013. © 2013 Wiley Periodicals, Inc.


Eren E.,Ataturk Hospital | Ellidag H.Y.,Research Hospital of Ministry of Health | Aydin O.,Maternity And Childrens Hospital | Kucukseymen S.,Antalya Education and Research Hospital of Ministry of Health | And 3 more authors.
Biomedical Research (India) | Year: 2015

As the role of oxidative stress on human diseases, including the cardiovascular system disorders, has accentuated, the ultimate need of reliable markers of oxidative stress becomes more imperative. We aimed to measure: activities of HDL-associated antioxidant enzymes, paraoxonase (PON1) and arylesterase (ARE); total oxidative (TOS) and antioxidative status (TAS), in heart failure (HF) patients, and search for correlations of these markers. The study group consisted of 70 subjects with HF. The patients were classified in three groups according to the suggestions of New York Heart Association. Serum levels of PON1, ARE, TOS, TAS, brain natriuretic peptide (BNP), uric acid (UA), creatinine, and lipid parameters were determined. The oxidative status index (OSI) was calculated. Plasma PON1 activity was significantly decreased (p=0.04), while BNP and UA levels were significantly increased(p<0.0001, p= 0.03, respectively), with the severity of the disease. ARE, TAS, TOS, and OSI did not show any statistically significant difference. Statistical analysis showed negative correlation between PON1, ARE activities and BNP; positive correlation between disease duration, UA and BNP. Also, a positive correlation was determined between TAS and UA. We report for the first time a notable relationship between HDL-associated anti-oxidant PON-1 activity and New York Heart Association classification for HF .These prominent results provide further support for the role for oxidative processes in the disease progression of HF and for the anti-oxidant compensatory role of HDL. We believe in the potential of antioxidant medications in HF and promote proper oxidative stress markers in routine use in diagnosis and follow-up. © 2015 Scientific Publishers of India. All rights reserved.


Selcuk B.,Kocaeli University | Kurtaran A.,Research Hospital of Ministry of Health | Yildirim O.,Research Hospital of Ministry of Health | Deirmenci I.,Research Hospital of Ministry of Health | Akyuz M.,Research Hospital of Ministry of Health
Neurosurgery Quarterly | Year: 2015

Objective: Clinical presentation of the ulnar nerve lesions in the wrist and hand shows variations because of complex anatomic course of the nerve in distal sites. Cyclist's palsy has been postulated to be an entrapment neuropathy of the ulnar nerve in the Guyon canal of the wrist. We report a case compression of the deep motor branch of the ulnar nerve as cyclist's palsy in women learning to ride a bike. Case Report: Hand weakness with no evidence of sensory symptoms was the initial presentation that brought the patient to the physician. Her thumb adduction was grade 3/5, fingers' adduction and abduction were grade 3/5, flexions from the fourth and fifth metacarpaphangeal joint were grade 4/5, and froment's sign was positive. Routine motor nerve conduction studies on the left ulnar nerve recording from abductor digiti minimi muscle were normal. However, stimulation from the left wrist and recording from the first dorsal interosseous muscle revealed a small amplitude (2.2 mV) and a prolonged distal latency (4.7 ms). The needle electromyography studies showed fibrillation potentials and positive sharp waves in the left first and third interosseous muscles and the adductor pollicis muscle. Conclusions: This may be owing to the fact that tight grasp in an inappropriate position and hyperextension position of the hand during biking are thought to be the main mechanisms of this lesion type. © 2014 Wolters Kluwer Health, Inc. All rights reserved.

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