Gent, Belgium
Gent, Belgium

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Drabowicz J.,Polish Academy of Sciences | Drabowicz J.,Jan Dlugosz University in Czestochowa | Krasowska D.,Polish Academy of Sciences | Lopusinski A.,Polish Academy of Sciences | And 2 more authors.
Current Organic Chemistry | Year: 2010

This review presents the use of cyclic tri- and pentavalent amidoesters and diamides with a stereogenic phosphorus as chiral stoichiometric auxiliaries in asymmetric synthesis. It shows that these compounds are especially useful for the preparation of selected acyclic enantiomerically (diastereomerically) pure (or enriched) tricoordinated-trivalent and tetracoordinated-pentavalent derivatives and as precursors of stereogenic phosphorus-containing carbanions. Their utility in a few other asymmetric reactions is also discussed.


De Blieck A.,Research Group SynBioC | Masschelein K.G.R.,Research Group SynBioC | Dhaene F.,Research Group SynBioC | Rozycka-Sokolowska E.,Jan Dlugosz University in Czestochowa | And 3 more authors.
Chemical Communications | Year: 2010

Trialkyl and silylated dialkyl phosphites were evaluated as phosphorus nucleophiles for the addition to quinolines in a strong acidic medium allowing consecutive 1,4- and 1,2-addition breaking up the aromatic stabilisation, thereby leading to 2,4-diphosphono-1,2,3,4-tetrahydroquinolines in one single reaction step in moderate to good yields (2-84%). © 2010 The Royal Society of Chemistry.

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