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Gomez-Perez M.L.,Research Group analytical Chemistry of Contaminants | Romero-Gonzalez R.,Research Group analytical Chemistry of Contaminants | Plaza-Bolanos P.,Research Group analytical Chemistry of Contaminants | Genin E.,Thermo Fisher Scientific | And 2 more authors.
Journal of Mass Spectrometry | Year: 2014

A multiresidue and multiclass method for the simultaneous determination of more than 350 compounds including pesticides, biopesticides and veterinary drugs in different meat matrices (beef, pork and chicken) by ultra-high performance liquid chromatography coupled to Orbitrap MS has been developed. In the present study, the determination of fragments was accomplished as an essential tool for a reliable identification of compounds using high resolution MS. To obtain these fragments, different strategies have been carried out in order to ensure an appropriate fragment assignment and identification. The analytical method is suitable for qualitative analysis, and it was also evaluated for quantitative analysis. Generic extraction conditions were optimized, obtaining adequate recovery and precision values for most of the studied analytes (>290). The limits of detection ranged from 2 to 16 μgkg-1. Limits of quantification were 10 μgkg-1 with the exception of few compounds with a higher value (50 or 100 μgkg-1). Limits of identification were also established, and they ranged from 2 to 150 μgkg-1. This method was applied to the analysis of 18 meat samples and some veterinary drugs as enrofloxacin and sulfadiazine were detected and further identified/quantified (with triple quadrupole) in two different samples at 33 μgkg-1 and trace levels, respectively. No pesticides were detected in the analyzed samples. Copyright © 2014 John Wiley & Sons, Ltd. Source


Martinez-Dominguez G.,Research Group analytical Chemistry of Contaminants | Plaza-Bolanos P.,Research Group analytical Chemistry of Contaminants | Romero-Gonzalez R.,Research Group analytical Chemistry of Contaminants | Garrido-Frenich A.,Research Group analytical Chemistry of Contaminants
Talanta | Year: 2014

A review of sample preparation and analytical techniques currently used to analyze pesticides in nutraceutical products is shown. Different sample treatments are commented, and the QuEChERS method is the most used (quick, easy, cheap, effective, rugged and safe). For the chromatographic determination, gas chromatography (GC) and liquid chromatography (LC) are evaluated. Different detection modes are discussed, and simple quadrupole mass spectrometry (Q-MS) and triple quadrupole tandem mass spectrometry (QqQ-MS/MS) are the most used. Finally, a review of the occurrence of pesticides (from the revised literature) in real samples is presented, evaluating several matrices, such as nutraceuticals, dietary supplements, medicinal plants, and fish oil. The occurrence of several pesticides was reported: γ-HCH (lindane), endosulfan, procymidone, azoxystrobin, p,p′-DDE, metalaxyl, quintozene, tolclofos-methyl, chlorpyrifos and hexachlorobenzene. © 2013 Elsevier B.V. Source


Alarcon-Flores M.I.,Research Group analytical Chemistry of Contaminants | Hernandez-Sanchez F.,Research Group analytical Chemistry of Contaminants | Romero-Gonzalez R.,Research Group analytical Chemistry of Contaminants | Plaza-Bolanos P.,Research Group analytical Chemistry of Contaminants | And 2 more authors.
International Journal of Food Sciences and Nutrition | Year: 2014

Phytochemicals content, including several families such as phenolic acids, isoflavones, flavones, flavonols, isothiocyanates, and glucosinolates, was determined in pre-cooked convenience vegetables by ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry (UHPLC-QqQ-MS/MS). It was observed that there is not a common behavior of the individual concentration of phytochemicals during the lifetime and cooking of the matrix, and compounds change their concentration without a specific trend. It was observed that neither lifetime nor cooking process have significant effects on the total content of phytochemicals except in broccoli, although some changes in the individual content of the target compounds were observed, suggesting that interconversion processes could be performed during the lifetime and/or cooking process of the product. © 2014 Informa UK Ltd. All rights reserved. Source

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