Research Foundation Itsuu Laboratory

Setagaya ku, Japan

Research Foundation Itsuu Laboratory

Setagaya ku, Japan
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Patent
Shionogi & Co. and Research Foundation Itsuu Laboratory | Date: 2013-12-04

A compound of the formula:Y^(1) is NP^(2) or O;P^(1) and P^(2) are independently hydrogen, or a substituent selected from Substituent Group S1 and amino protecting group;R^(11) is hydrogen, or a substituent selected from Substituent Group S1 and amino protecting group, with the proviso that R^(11) is not -CO(CH_(2))_(3)-CO_(2)H, -Ph, -CH_(2)Ph, and -(CH_(2))_(3)CH(4-F-Ph)_(2) wherein Ph is phenyl;Substituent Group S1 consists of optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted formyl, optionally substituted (lower alkyl) carbonyl, optionally substituted cycloalkylcarbonyl, optionally substituted (lower alkyl) oxycarbonyl, optionally substituted (lower alkyl) oxythiocarbonyl, optionally substituted arylcarbonyl, optionally substituted aryloxycarbonyl, optionally substituted heterocyclecarbonyl, optionally substituted heterocycleoxycarbonyl, optionally substituted carbamoyl, optionally substituted carbamoylcarbonyl, optionally substituted thiocarbamoyl, optionally substituted (lower alkyl) thiocarbonyl, optionally substituted cycloalkylthiocarbonyl, optionally substituted arylthiocarbonyl, optionally substituted heterocyclic thiocarbonyl, optionally substituted (lower alkyl) sulfonyl, optionally substituted phenylsulfonyl, optionally substituted aromatic heterocyclesulfonyl, optionally substituted aminosulfonyl, optionally substituted aryl, optionally substituted heterocyclic group, cyano, optionally substituted thioformyl, optionally substituted (lower alkenyl) carbonyl, and optionally substituted heterocycleoxycarbonyl;with the proviso that the compound is not the following compound:wherein Ph is phenyl.


Patent
Kemphys Ltd. and Research Foundation Itsuu Laboratory | Date: 2012-04-19

A compound represented by the formula (I) [R^(1 )to R^(8 )represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R^(4 )represents an amino group or (CX_(2))_(m)COOH (m represents 0 to 3, and X represents hydrogen atom); R^(5 )represents (CY_(2))_(p)COOR^(6 )(p represents an 0 to 3, Y represents hydrogen atom, and R^(6 )represents hydrogen atom or an alkyl group)], or a salt thereof.


Patent
Research Foundation Itsuu Laboratory and Kemphys Ltd. | Date: 2014-02-26

A compound represented by the formula (I) [R^(1) to R^(3) represent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; R^(4) represents an amino group or - (CX_(2))_(m)-COOH (m represents 0 to 3, and X represents hydrogen atom); R^(5) represents-(CY_(2))_(p)-COOR^(6) (p represents an 0 to 3, Y represents hydrogen atom, and R^(6) represents hydrogen atom or an alkyl group)], or a salt thereof.


Patent
Kemphys Ltd. and Research Foundation Itsuu Laboratory | Date: 2012-04-30

A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.


Patent
Research Foundation Itsuu Laboratory and Shionogi&Co. Ltd. | Date: 2010-05-05

A compound of the formula:Ring A is(A-1) at least 7-membered monocyclic hetero ring containing at least three N atoms;(A-2) at least 6-membered monocyclic hetero ring containing at least two N atoms and at least one O atom; or(A-3) at least 7-membered monocyclic hetero ring containing at least two N atoms and at least one S atom, wherein said monocyclic hetero ring is optionally substituted, and said monocyclic hetero ring is optionally condensed with another ring,X^(1) is a single bond, or a hetero atom-containing group selected from the group consisting of -O-, -S-, -NR^(2)-, -CO-, -CS-, -CONR^(3)-, -NR^(4)CO-, -SO_(2)NR^(5)-, and -NR^(6)SO_(2)-, wherein R^(2), R^(3), R^(4), R^(5) and R^(6) are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said hetero atom-containing group;Ring B is optionally substituted carbocycle or optionally substituted heterocycle;R^(1) is hydrogen, or an organic residue which is able to bind to the 5-position of oxazolidinone ring in oxazolidinone antimicrobial agent.


Patent
Research Foundation Itsuu Laboratory and Shionogi&Co. Ltd. | Date: 2010-07-21

The present invention provides a novel oxazolidinone derivative of the formula (I):Ring A is(A-1) a 7-membered monocyclic heterocycle containing three N atoms;(A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or(A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO_(2),wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring;X^(1) is a single bond, or a heteroatom-containing group selected from the group consisting of -O-, -S-, -NR^(2)-, -CO-, -CS-, -CONR^(3)-, -NR^(4)CO-, -SO_(2)NR^(5)-, and -NR^(6)SO_(2)-, wherein R^(2), R^(3), R^(4), R^(5) and R^(6) are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group;Ring B is optionally substituted carbocycle or optionally substituted heterocycle; andR^(1) is hydrogen, or an organic residue which is able to bind to the 5-position of the oxazolidinone ring in oxazolidinone antimicrobial agents,pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.


Patent
Research Foundation Itsuu Laboratory | Date: 2012-07-04

A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient.


Patent
Research Foundation Itsuu Laboratory | Date: 2010-05-26

A compound represented by the following general formula (I):^(1) represents hydrogen atom or a C_(16) alkyl group, A and B represent -(CH_(2))_(2)-, -(CH_(2))_(3)- or -(CH_(2))_(4)-, X represents -N(R^(2))- (R^(2) represents hydrogen atom or a C_(1-6) alkyl group), -CO-, -C(=N-R^(3))- (R^(3) represents hydrogen atom or a C_(1-6) alkyl group), or - C(=C(R^(4))(R^(5)))- (R^(4) and R^(5) independently represent hydrogen atom or a C_(1-6) alkyl group), and Ar represents an aryldiyl group or a heteroaryldiyl group], which has an action of controlling physiological activities of retinoids and useful as an active ingredient of a medicament.


Patent
Research Foundation Itsuu Laboratory | Date: 2010-05-26

A compound represented by the following general formula (I):^(1) and R^(2) represent an alkyl group, X represents -S-, -O- or -NH-, Y represents C or N, R^(3) represents hydrogen atom or a C_(1-10) alkyl group, Z represents CO-N(R^(5))- (R^(5) represents hydrogen atom or a C_(1-6) alkyl group) or -C(R^(6))=C(R^(7))-CO-NH-(R^(6) and R^(7) represent hydrogen atom or a C_(1-6) alkyl group), Ar represents an aryldiyl group or a heteroaryldiyl group, and R^(4) represents -COOH, -OCH_(2)-COOH, -CH_(2)-COOH, or -CH_(2)-CH_(2)-COOH], which has a retinoid action and is useful as an active ingredient of a medicament.


Patent
Research Foundation Itsuu Laboratory | Date: 2014-05-14

A compound corresponding to 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]phenyl]propionic acid in which a part or all of hydrogen atoms in the ethylene group constituting the propionic acid moiety are replaced with deuterium atoms, a salt thereof, or an ester thereof, and a prodrug for releasing Am80 as an active medicament after being absorbed into a living body, which comprises the aforementioned compound, a salt thereof, or an ester thereof as an active ingredient.

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