Research Foundation for Mental Hygiene
Research Foundation for Mental Hygiene
Ezell J.M.,University of Chicago |
Choi C.-W.J.,Research Foundation for Mental Hygiene |
Wall M.M.,Columbia University |
Link B.G.,University of California at Riverside
Community Mental Health Journal | Year: 2017
We present an exploratory factor analysis of the 8-item Daily Indignities of Mental Illness (DIMI) scale, created to measure the detection and perceptions of recurring stigma among individuals with recent psychiatric hospitalizations. Structured in-person interviews were conducted with individuals with recent psychiatric hospitalizations in metropolitan New York. The 8-item DIMI scale’s internal consistency for the sample (n = 65), measured by Cronbach’s alpha, was 0.869. Statistically significantly higher DIMI scale scores were observed among individuals with more than 2 psychotic episodes and those reporting seeing relatives less often after hospitalization. The DIMI scale possesses good internal consistency for research contextualizing perceptions around the occurrence or recurrence of mental illness-related stigma among individuals with recent psychiatric hospitalizations. © 2017 Springer Science+Business Media, LLC
Chen W.V.,Columbia University |
Nwakeze C.L.,Columbia University |
Denny C.A.,Columbia University |
Denny C.A.,Research Foundation for Mental Hygiene |
And 9 more authors.
Science | Year: 2017
Serotonergic neurons project their axons pervasively throughout the brain and innervate various target fields in a space-filling manner, leading to tiled arrangements of their axon terminals to allow optimal allocation of serotonin among target neurons. Here we show that conditional deletion of the mouse protocadherin α (Pcdhα) gene cluster in serotonergic neurons disrupts local axonal tiling and global assembly of serotonergic circuitries and results in depression-like behaviors. Genetic dissection and expression profiling revealed that this role is specifically mediated by Pcdhαc2, which is the only Pcdhα isoform expressed in serotonergic neurons. We conclude that, in contrast to neurite self-avoidance, which requires single-cell identity mediated by Pcdh diversity, a single cell-type identity mediated by the common C-type Pcdh isoform is required for axonal tiling and assembly of serotonergic circuitries. Copyright © 2016 by the American Association for the Advancement of Science; all rights reserved.
Trifilieff P.,Columbia University |
Trifilieff P.,New York State Psychiatric Institute |
Trifilieff P.,Research Foundation for Mental Hygiene |
Rives M.-L.,Research Foundation for Mental Hygiene |
And 13 more authors.
BioTechniques | Year: 2011
The existence of G protein-coupled receptor (GPCR) dimers and/or oligomers has been demonstrated in heterologous systems using a variety of biochemical and biophysical assays. While these interactions are the subject of intense research because of their potential role in modulating signaling and altering pharmacology, evidence for the existence of receptor interactions in vivo is still elusive because of a lack of appropriate methods to detect them. Here, we adapted and optimized a proximity ligation assay (PLA) for the detection in brain slices of molecular proximity of two antigens located on either the same or two different GPCRs. Using this approach, we were able to confirm the existence of dopamine D2 and adenosine A2A receptor complexes in the striatum of mice ex vivo.
PubMed | NYS Office of Alcoholism and Substance Abuse Services, Research Foundation for Mental Hygiene, Office of Diversity and Inclusion, Michigan State University and LGBT Center
Type: Journal Article | Journal: The journal of behavioral health services & research | Year: 2015
This report presents results of Project LINK, a Substance Abuse and Mental Health Services Administration (SAMHSA)-funded, 5-year collaboration (2007-2012) between New York City (NYC) health and NY State substance abuse disorder (SUD) agencies, an LGBT organization contractor, and multiple SUD, social service, and mental health referral agencies. LINK allowed the first ever SUD screening, brief intervention, and referrals to treatment (SBIRT) intervention services onsite in NYC Bureau of Sexually Transmitted Disease Control (BSTDC) clinics. Factors favoring collaboration were (a) joint recognition of substance abuse as an STD risk factor; (b) prior collaborations; (c) agreement on priority of BSTDCs mission and policies; (d) extensive SBIRT training, cross training on STDs; (e) a memorandum of agreement; and (f) mutual transparency of collaborative efforts, among others. LINK screened over 151,000 STD clinic patients and delivered brief interventions to 60% of positively screened patients and met a mandated follow-up target. Factors found to facilitate collaboration here may help screen prospective new health collaborations.
Morgenstern J.,Columbia University |
Kuerbis A.N.,Columbia University |
Kuerbis A.N.,Research Foundation for Mental Hygiene |
Chen A.C.,Columbia University |
And 4 more authors.
Journal of Consulting and Clinical Psychology | Year: 2012
Objective: This study tested the comparative effectiveness of modified behavioral self-control therapy (MBSCT) and naltrexone (NTX), as well as the added benefit of combining the 2, in problem drinking men who have sex with men (MSM) seeking to reduce but not quit drinking. Method: Participants (N = 200) were recruited and urn randomized to 1 of 2 medication conditions, NTX or placebo (PBO), and either MSBCT or no behavioral intervention, yielding 4 conditions: PBO, NTX, MSBCT, and NTX + MSBCT. In addition, all participants received a brief medication compliance intervention. Participants were treated for 12 weeks and assessed 1 week after treatment completion. Two primary outcomes-sum of standard drinks and number of heavy drinking days-and 1 secondary outcome-percentage of those drinking in a nonhazardous manner (NoH)-were selected a priori. Results: There was a significant main effect for MBSCT (all ps <.01) but not NTX on all 3 outcomes. In addition, the combination of NTX and MBSCT was not more effective than either MSCBT or PBO. There was a significant interaction effect on NoH, such that NTX significantly increased the likelihood (odds ratio = 3.3) of achieving a nonhazardous drinking outcome relative to PBO. In addition, NTX was significantly more effective than PBO on a descriptive outcome: negative consequences of drinking. Conclusions: There was no advantage to adding NTX to MBSCT. In addition, MBSCT showed stronger evidence of efficacy than NTX. At the same time, NTX delivered in the context of a minimal medication compliance intervention was significantly more effective than PBO on an important clinical indicator. Results provide new information to guide the treatment of problem drinking, including in primary care settings. © 2012 American Psychological Association.
Drew L.J.,Columbia University |
Drew L.J.,Research Foundation for Mental Hygiene |
Stark K.L.,Columbia University |
Fenelon K.,Columbia University |
And 3 more authors.
Molecular and Cellular Neuroscience | Year: 2011
22q11.2 chromosomal deletions are recurrent copy number mutations that increase the risk of schizophrenia around thirty-fold. Deletion of the orthologous chromosomal region in mice offers an opportunity to characterize changes to neuronal structure and function that may account for the development of this disease. The hippocampus has been implicated in schizophrenia pathogenesis, is reduced in volume in 22q11.2 deletion carriers and displays altered neuronal structure in a mouse model of the mutation (Df(16)A +/- mice). Here we investigate hippocampal CA1 physiology, hippocampal-dependent spatial memory and novelty-induced hippocampal activation in Df(16)A +/- mice. We found normal spatial reference memory (as assayed by the Morris water maze test) as well as modest but potentially important deficits in physiology. In particular, a reduction in the level of inhibition of CA1 pyramidal neurons was observed, implying a decrease in interneuron activity. Additionally, deficits in LTP were observed using certain induction protocols. Induction of c-Fos expression by exploration of a novel environment suggested a relative sparing of CA1 and dentate gyrus function but showed a robust decrease in the number of activated CA3 pyramidal neurons in Df(16)A +/- mice. Overall, experiments performed in this 22q11.2 deletion model demonstrated deficits of various degrees across different regions of the hippocampus, which together may contribute to the increased risk of developing schizophrenia. © 2011 Elsevier Inc.
Kim S.,Columbia University |
Kim S.,Research Foundation for Mental Hygiene |
Ades M.,Research Foundation for Mental Hygiene |
Ades M.,Columbia University |
And 6 more authors.
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | Year: 2014
The Affordable Care Act (ACA) creates incentives to coordinate primary care, mental health (MH) care, and addiction services. Integration of clinical HIV and MH services has been shown to improve quality of life and physical and MH of people living with HIV/AIDS. However, few studies have investigated the practice of service integration systematically. We examined the practice patterns of 515 direct service providers in New York State who received training about HIV MH between May 2010 and July 2012. We sought to identify provider and treatment setting characteristics associated with an integrated spectrum of care. Using factor analysis and linear modeling, we found that patterns of service integration varied by type of health-care setting, service setting location, providers' HIV caseload, and the discipline of the provider describing the direct services. Understanding the existing capacities of clinicians providing care in a variety of settings throughout New York will help to guide staffing and linkage to enhance HIV MH service integration as significant shifts in the organization of health care occur. © 2014 Taylor & Francis.
Kuerbis A.,Research Foundation for Mental Hygiene |
Hayes M.,Research Foundation for Mental Hygiene |
Morgenstern J.,Columbia University
Journal of Social Work Practice in the Addictions | Year: 2013
As baby boomers age, identifying effective and efficacious interventions for older adults (OA) with alcohol use disorder is vital for the ongoing viability of the health care system. Brief alcohol use disorder interventions with OA have yet to be examined in the context of studies with high internal validity. Post-hoc, exploratory, single-system analyses were performed on 10 OA and 13 middle-aged problem drinkers who had participated in a randomized controlled trial. Their trajectories were compared to peer age groups who received no treatment. Although OA appeared to respond to most interventions, some interventions yielded greater response than others. Implications are discussed. © 2013 Copyright Taylor and Francis Group, LLC.
Muench F.,Columbia University |
Hayes M.,Research Foundation for Mental Hygiene |
Kuerbis A.,Columbia University |
Shao S.,Research Foundation for Mental Hygiene
Journal of Behavioral Addictions | Year: 2015
Background and Aims: There is an emerging literature base on the relationship between maladaptive traits and "addiction" to social networking sites. These studies have operationalized addiction as either spending excessive amounts of time on social networking sites (SNS) or trouble controlling SNS use, but have not assessed the unique contribution of each of these constructs on outcomes in the same models. Moreover, these studies have exclusively been conducted with younger people rather than a heterogeneous sample. This study examined the independent relationship of a brief Facebook addiction scale, time spent on Facebook, and Facebook checking on positive and negative social domains, while controlling for self-esteem and social desirability. Methods: Participants were recruited using e-mail, SNS posts and through Amazon's MTurk system. The sample included 489 respondents ages from 18 to approximately 70, who completed a 10-15 minute survey. Results: Results indicate that neither time spent on Facebook nor Facebook checking was significantly associated with either self-esteem, fear of negative social evaluation or social comparison, while SNS addiction symptoms were each independently associated with Facebook usage. Neither time spent on Facebook nor SNS addiction symptoms were associated with positive social relationships. Discussion: Overall results suggest that time on SNS and trouble controlling use should be considered independent constructs and that interventions should target underlying loss of control as the primary intervention target above ego syntonic time spent on the site. © 2015 Akadémiai Kiadó, Budapest.
PubMed | Research Foundation for Mental Hygiene and Columbia University
Type: Journal Article | Journal: Journal of behavioral addictions | Year: 2015
There is an emerging literature base on the relationship between maladaptive traits and addiction to social networking sites. These studies have operationalized addiction as either spending excessive amounts of time on social networking sites (SNS) or trouble controlling SNS use, but have not assessed the unique contribution of each of these constructs on outcomes in the same models. Moreover, these studies have exclusively been conducted with younger people rather than a heterogeneous sample. This study examined the independent relationship of a brief Facebook addiction scale, time spent on Facebook, and Facebook checking on positive and negative social domains, while controlling for self-esteem and social desirability.Participants were recruited using e-mail, SNS posts and through Amazons MTurk system. The sample included 489 respondents ages from 18 to approximately 70, who completed a 10-15 minute survey.Results indicate that neither time spent on Facebook nor Facebook checking was significantly associated with either self-esteem, fear of negative social evaluation or social comparison, while SNS addiction symptoms were each independently associated with Facebook usage. Neither time spent on Facebook nor SNS addiction symptoms were associated with positive social relationships.Overall results suggest that time on SNS and trouble controlling use should be considered independent constructs and that interventions should target underlying loss of control as the primary intervention target above ego syntonic time spent on the site.