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Marquez-Aguirre A.L.,Research Center y Asistencia en Tecnologia y | Canales-Aguirre A.A.,Research Center y Asistencia en Tecnologia y | Gomez-Pinedo U.,CIBER ISCIII | Galvez-Gastelum F.J.,University of Guadalajara
Neurologia | Year: 2010

Introduction: Liver fibrosis and its end stage, cirrhosis, is an enormous worldwide health problem. Hepatic encephalopathy (HE) or portal-systemic encephalopathy continues to be a majorclinical problem of long-term cirrhosis. In this review we emphasise the molecular basis of HE and the involvement of oxidative stress in the development of this disease. Background: Several studies suggest that the pathogenesis of HE could be multifactorial and have implicated different factors, such as alterations in blood brain barrier, substances; such as ammonia and manganese, neurotransmission disorders such as dopamine, glutamate and GABA. Development: HE is a severe complication of both acute and chronic liver failure. Neuropathologically, it is characterized by astrocyte changes known as Alzheimer type II astrocytosis. In addition, astrocytes manifest altered expression of astrocyte-specific proteins, such as, glial fibrillary acidic protein, glutamine synthetase, monoamine oxidase and peripheral type benzodiazepine receptors. Conclusions: HE is a complex neuropsychiatric syndrome associated with liver failure. These alterations are products of increases in oxidative stress in brain due to neurotoxin activity. The main strategy for HE treatment is directed at ammonia reduction, which can be achieved either by decreasing its absorption/production or increasing its removal. © 2009 Sociedad Española de Neurología. Source


Barba-Gonzalez R.,Research Center y Asistencia en Tecnologia y | Rodriguez-Dominguez J.M.,Research Center y Asistencia en Tecnologia y | De La Cruz-Cruz A.,Research Center y Asistencia en Tecnologia y | Lara-Banuelos T.Y.,Research Center y Asistencia en Tecnologia y | And 2 more authors.
Acta Horticulturae | Year: 2013

Polianthes tuberosa, known locally as "Tuberose" or "Nardo" has been utilized as an ornamental crop since prehispanic times and also to extract volatile compounds for perfume fabrication. The genus Polianthes (Agavaceae) is endemic to Mexico and it comprises 14 species grouped in two taxonomic sections offering colored flowers ranging from scarlet red to yellow, which is a covetable characteristic over the white tuberoses. Accessions of different species have been collected from the wild and with the aim to develop a breeding program, the different genotypes were characterized by amplified fragment length polymorphism (AFLP).The compatibility among species has been tested and interspecific and intersectional hybridization has been achieved. The results of the present study indicate the molecular variability among species, the creation of interspecific hybrids of Polianthes and the possibility to combine important horticultural traits from wild species into novel tuberose cultivars. Source

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