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Ymittos Athens, Greece

Voloudakis G.E.,Research Center panikolaou | Baltatzis G.E.,Research Center panikolaou | Kandylis K.,Medical Oncology Clinic | Arnogiannakis N.,St. Savvas Anticancer Hospital | And 2 more authors.
Ultrastructural Pathology | Year: 2010

In this study, cell surface projections of primary culture cells from tissues of infiltrating ductal carcinoma Non Special Type with vascular invasion are examined by use of the Scanning Electron Microscopy method. In these cases the projections of cell membrane appeared extremely long and bridge-like covering very long distances between the breast cancer cells. Also, the long cell membrane projections, connect cells between them and form a complex. Sometimes, from one edge to another we observed a very long chain of cancer cells reaching sometimes a length of 3, 3mm. On the other hand the absence of vascular invasion never shows such long projections of the cell membrane even if there are many metastatic nodes. The role of these extra long projections in communication between cancer cells is determinant. Through this communication, these long projections seemed to be responsible for the metastatic process in primary breast cancer with vascular invasion. © 2009 Informa UK Ltd. Source


Baltatzis G.E.,Research Center panikolaou | Voloudakis G.E.,Research Center panikolaou | Arnogiannakis N.,St. Savas Anticancer Hospital | Misitzis J.,St. Savas Anticancer Hospital | Voloudakis-Baltatzis I.E.,Research Center panikolaou
Ultrastructural Pathology | Year: 2011

The tubular carcinoma of the breast is an uncommon histological subtype of invasive breast cancer, which is generally associated with an excellent prognosis. Previous studies have demonstrated that this well differentiated variant is linked with a low incidence of lymph node involvement, a low rate of local recurrence and a high overall survival rate when compared to standard invasive ductal carcinoma. Due to its favorable prognosis, some studies have proposed that a diagnosis of tubular carcinoma might warrant less aggressive surgical or adjuvant treatment. Histologically, tubular carcinoma may mimic sclerosing adenoma or bluntduct adenosis. Its ductal nature appears well confirmed by the few ultrastructural studies of this mammary cancer. Tubular carcinoma should also be distinguished from microglandular adenosis, an uncommon form of sclerosing adenosis. The aim of this study is to prove that the ultrastructure results can give the correct diagnosis between tubular carcinoma and sclerosing adenosis. © 2011 Informa Healthcare USA, Inc. Source


Baltatzis G.E.,Research Center panikolaou | Gaitanarou H.,Research Center panikolaou | Arnogianaki N.,St. Savas Anticancer Hospital | Misitzis J.,St. Savas Anticancer Hospital | Voloudakis-Baltatzis I.E.,Research Center panikolaou
Ultrastructural Pathology | Year: 2011

Mucinous infiltrating invasive ductal adenocarcinoma consists of 2-4% invasive breast cancer, but is a very interesting type due to its macroscopic similarity to non-special-type (NST) ductal carcinoma. The macroscopic similarity of mucinous and infiltrating ductal carcinoma NST adenocarcinomas consists of a loose and edematous stroma, which is often seen in portions of NST carcinoma and may mimic the mucin pools of mucinous carcinoma. In this study the authors examined the ultrastructural differences between mucinous carcinoma and infiltrating ductal carcinoma NST. They also examined the protein expression of the tissues by 2D electrophoresis due to their belief that from the results of these two levels it is possible to understand the changes that take place both in the ultrastructural and biochemical levels in these two types of breast cancer. The ultrastructural results from mucinous carcinoma have shown many changes in cytoplasmic organelles in comparison to normal samples, depending on the grade and the number of metastatic lymph nodes. At the 2D elecrophoresis level the authors studied two interesting polypeptides, calreticulin and thioredoxin. Both of these proteins were found in patterns of fibroadenoma, mucinous carcinoma, and NST carcinoma, but with different quantitative expression among them. In the future the quantitative differences of these two proteins may provide specific tumor markers for these two types of carcinoma. Copyright © 2011 Informa Healthcare USA, Inc. Source

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