Research Center for the Examination of Medical Products

Petrovskiy, Russia

Research Center for the Examination of Medical Products

Petrovskiy, Russia

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Kuz'mina N.E.,Research Center for the Examination of Medical Products | Moiseev S.V.,Research Center for the Examination of Medical Products | Krylov V.I.,Research Center for the Examination of Medical Products | Yashkir V.A.,Research Center for the Examination of Medical Products | Merkulov V.A.,Research Center for the Examination of Medical Products
Journal of Analytical Chemistry | Year: 2014

Diffusion ordered NMR (DOSY) was applied to the determination of the average molecular weights of polymers based on the dependence of the measured self-diffusion coefficient D on the corresponding weights of a number of polymers of the same type. As a rule, a calibration function is plotted by varying DOSY experimental parameters for each particular test sample; however, this approach is inapplicable to the development of a standard procedure for the quantitative assessment of the molecular weights of dextrans. In this article, an optimization method is considered to ensure high resolution in terms of the values of D for dextrans without varying experimental conditions; this method makes it possible to evaluate the average molecular weights of dextrans with a high accuracy over a wide range of their values. © 2014, Pleiades Publishing, Ltd.

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