Research Center for Psychiatry and Behavioral science

science, Iran

Research Center for Psychiatry and Behavioral science

science, Iran

Time filter

Source Type

Javadpour A.,Research Center for Psychiatry and Behavioral science | Sahraian A.,Research Center for Psychiatry and Behavioral science | Rahman-Haghighi E.,Shiraz University of Medical Sciences
Shiraz E Medical Journal | Year: 2012

Background: Medical residents are a population who are at great risk to develop sleep disruption due to demanding clinical and academic duties. Knowing how much change in sleep wake pattern is associated with subsequent psychological distress could be useful to establish a systematic mental health program for medical residents. Method: a cross sectional study was conducted to explore the association between shift works and general health status of 128 medical residents. A self report sleep-wake questionnaire and general health questionnaire (GHQ) were used to test the pattern of sleep-wake and general health status respectively. Result: There was a significant correlation between sleep disruption and general health status of study sample (p=0.001).number of night shift was a predictor for general health among medical residents. Conclusion: sleep disruption due to shift work could be a predictor for mental morbidity. Reduce in night time shift among medical residents might prevent both physical and mental morbidity among them. © 2012, Shiraz E Medical Journal. All rights reserved.


Ghanizadeh A.,Research Center for Psychiatry and Behavioral science | Nouri S.Z.,Shiraz University of Medical Sciences | Nabi S.S.,Shiraz University of Medical Sciences
Eastern Mediterranean Health Journal | Year: 2012

Data are lacking about the prevalence of psychiatric disorders and suicidal behaviour in incarcerated adolescents in Asia. This cross-sectional study evaluated the prevalence of psychiatric disorders and the prediction of suicidal attempts in 100 incarcerated males aged 12-19 years in Shiraz. Data were collected in face-to-face interview using the Kiddie Schedule for Affective Disorders and Schizophrenia (Farsi version). The mean age was 16.8 (SD 1.3) years and mean age at first imprisonment was 16.0 (SD 1.5) years. Nearly 70% of the adolescents had at least one current psychiatric disorder, the commonest being: conduct disorder (55%), oppositional defiant disorder (48%) and attention deficit hyperactivity disorder (33%); 11% had major depressive disorder and 2% schizophrenia. In all, 20% had self-harmed without intent to kill themselves and 12% had attempted suicide, 50% of whom had tried more than once. In logistic regression analysis only self-harming behaviour and major depressive disorder were significant predictors of attempted suicide.


Ghanizadeh A.,Research Center for Psychiatry and Behavioral science | Ghanizadeh A.,Shiraz University of Medical Sciences | Derakhshan N.,Shiraz University of Medical Sciences | Berk M.,Deakin University | Berk M.,University of Melbourne
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry | Year: 2013

Nail biting is a common behavioral problem. While there are established behavioral interventions for management, they are of modest efficacy, and there is minimal evidence for effective pharmacotherapy. This study investigated the role of N-acetylcysteine (NAC) a potent glutathione and glutamate modulator for the treatment of pathological nail biting in children and adolescents. This pilot randomized, double-blind, placebo-controlled clinical trial of NAC (800mg/day) or placebo enrolled 42 children and adolescents with chronic nail biting. Nail length was the objective outcome. Evaluations were carried out three times; before treatment, one month after enrollment in the study, and two months after enrollment. The duration (chronicity) of nail biting in the NAC and placebo groups was 3.63(2.45) and 5.09(3.74) years (P=0.14). The mean nail length gradually increased in both the NAC and placebo groups during this trial. There was a statistically significant difference between the two groups regarding increased nail length after the first month of trial [(5.21(5.75) and 1.18(3.02) millimeters], however no difference after two months was observed. Two patients in the NAC group discontinued medication due to adverse events. One patient experienced headache, agitation, and social withdrawal, and another patient expressed severe aggression after taking medication and was withdrawn from the study. This study supports the hypothesis that NAC decreases nail biting behavior in children and adolescents over the short term. NAC is relatively well tolerated and severe adverse effects are rare. However, there was a high rate of dropout. Further studies with longer durations that build on these preliminary data are recommended. This study is registered at the Iranian Registry of Clinical Trials (Irct registration number: IRCT201103023930N3). © 2013 Bentham Science Publishers.


Ghanizadeh A.,Research Center for Psychiatry and Behavioral science | Ghanizadeh A.,Shiraz University of Medical Sciences | Derakhshan N.,Research Center for Psychiatry and Behavioral science
Journal of Research in Medical Sciences | Year: 2012

There are a limited number of Food and Drug Administration (FDA)-approved medications for the treatment of autism. Meanwhile, oxidative stress and neuroinflammation are supposed to play a causative role in autism. N-acetylcysteine may provide cystine, a precursor for glutathione (GSH), which is an important antioxidant factor in the brain. We here report a child with autism, whose symptoms were markedly decreased after taking oral N-acetylcysteine 800 mg/day, in three divided doses. His social interaction was significantly increased. The score of social impairment on a visual analog scale decreased from 10 to 6 in the two-month trial. The aggressive behaviors decreased from 10 to 3. This case suggests that N-acetylcysteine may decrease some symptoms of autism.


Ghanizadeh A.,Research Center for Psychiatry and Behavioral science | Ghanizadeh A.,Shiraz University of Medical Sciences
European Review for Medical and Pharmacological Sciences | Year: 2013

OBJECTIVE: Bruxism or sleep jaw clenching and grinding of the teeth is an unresolved area in dentistry, psychiatry, and medicine. While many therapeutic approaches are introduced, nearly all of them are not effective or some of them are invasive approach. Three children with sleep bruxismt-reated with hydroxyzine are reported. STUDY DESIGN: The parents reported the severity of sleep bruxism in their children. All the children used to co-sleep with their parents. Hydroxyzine 10 to 25 mg per night was administered for all of the three patients. They were followed up for one to two months. None of them had any remarkable general medical condition or temporomandibular joint problem. RESULTS: The parents reported a significant reduction in the score of Visual Analog Scale (VAS) after taking hydroxyzine for one month. Drug adverse effect was not reported or found. CONCLUSIONS: These reports suggest that hydroxyzine may be effective for the treatment of bruxism in children. It is worthwhile conducting placebo-controlled studies investigating the possible role of hydroxyzine for the treatment of bruxism in children.


PubMed | Shiraz University of Medical Sciences and Research Center for Psychiatry and Behavioral science
Type: Journal Article | Journal: International journal of trichology | Year: 2014

This is a review of psychiatric problems in patients with alopecia areata (AA). The electronic database of MedLine/PubMed was searched using the determined keywords. The rate of depression in children and adolescents with AA is up to 50%. Stressful life events are associated with AA. A rate of 39% for generalized anxiety disorders was reported. AA is highly associated with obsessive compulsive disorder (35.7%) in children and adolescents. Schizophrenia tended to be less seen in AA patients.

Loading Research Center for Psychiatry and Behavioral science collaborators
Loading Research Center for Psychiatry and Behavioral science collaborators