Research Center for Medicinal Plant Resources

Ibaraki, Japan

Research Center for Medicinal Plant Resources

Ibaraki, Japan
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Ibrar Shinwari M.,International Islamic University, Islamabad | Iida O.,Research Center for Medicinal Plant Resources | Ibrar Shinwari M.I.,Pakistan Scientific & Technological Information Center | Fujii Y.,Tokyo University of Agriculture and Technology | Fujii Y.,Japan National Institute for Agro - Environmental Sciences
Pakistan Journal of Botany | Year: 2017

Climate change impact is ready to interfere in agro-ecosystems. Improvement of adaptations of crops to forthcoming climatic changes must be focused in research. In the present study, leaf liter of 160 medicinal plant samples (156 species) belonging to 134 genera and 74 families were collected from Research Center for Medicinal Plant Resources, Tanegashima, Japan and subjected to evaluation of their allelopathic effects using the Sandwich method. Lettuce (Lactuca sativa L.) was used as a test plant material in the bioassay because of its reliability for germination. Top ten medicinal plant species found with maximum inhibition activity were Melia azedarach (Meliaceae) followed by Tylophora tanakae (Ascepiadaceae), Cinchona sp. (Rubiaceae), Flueggea virosa (Phyllanthaceae), Hibiscus acetosella (Malvaceae), Justicia procumbens (Acanthaceae), Terminalia chebula (Combretaceae), Hibiscus syriacus (Malvaceae), Lycium chinense (Solanaceae) and Elaeocarpus japonicas (Elaeocarpaceae). Moreover, the presented results also showed minimum growth inhibition or maximum growth stimulation by Ligustrum japonicum (Oleaceae) followed by Vitex rotundifolia (Lamiaceae) and Alpnia intermedia (Zingiberaceae).These results may be utilized as benchmark information for further research on the elucidation of chemicals involved in the allelopathy in nature. The information obtained could also be helpful in the development of new and potent bioactive chemicals from natural products. © 2017, Pakistan Botanical Society. All rights reserved.


Kakiuchi N.,University of Miyazaki | Atsumi T.,University of Miyazaki | Higuchi M.,University of Miyazaki | Kamikawa S.,University of Miyazaki | And 9 more authors.
Journal of Natural Medicines | Year: 2014

Aconite tuber is a representative crude drug for warming the body internally in Japanese Kampo medicine and Chinese traditional medicine. The crude drug is used in major prescriptions for the aged. Varieties of Aconitum plants are distributed throughout the Japanese Islands, especially Hokkaido. With the aim of identifying the medicinal potential of Aconitum plants from Hokkaido, 107 specimens were collected from 36 sites in the summer of 2011 and 2012. Their nuclear DNA region, internal transcribed spacer (ITS), and aconitine alkaloid contents were analyzed. Phylogenic analysis of ITS by maximum parsimony analysis showed that the majority of the specimens were grouped into one cluster (cluster I), separated from the other cluster (cluster II) consisting of alpine specimens. The aconitine alkaloid content of the tuberous roots of 76 specimens showed 2 aspects - specimens from the same collection site showed similar aconitine alkaloid profiles, and cluster I specimens from different habitats showed various alkaloid profiles. Environmental pressure of each habitat is presumed to have caused the morphology and aconitine alkaloid profile of these genetically similar specimens to diversify. © 2014 The Japanese Society of Pharmacognosy and Springer Japan.


Itoh Y.,Japan National Institute of Biomedical Innovation | Sanosaka M.,Japan National Institute of Biomedical Innovation | Fuchino H.,Research Center for Medicinal Plant Resources | Yahara Y.,Kyoto University | And 9 more authors.
Journal of Biological Chemistry | Year: 2015

Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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