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Itoh Y.,Japan National Institute of Biomedical Innovation | Sanosaka M.,Japan National Institute of Biomedical Innovation | Fuchino H.,Research Center for Medicinal Plant Resources | Yahara Y.,Kyoto University | And 9 more authors.
Journal of Biological Chemistry

Background: Salt-inducible kinases (SIKs) are capable of suppressing gluconeogenic gene expression in hepatocytes when they are overexpressed. Results: However, enhanced gluconeogenic programs are observed only in SIK3-defective hepatocytes. Conclusion: SIK3 is the major kinase that down-regulates gluconeogenesis. Significance: The present study proposes that SIK3 could be a new target of diabetic care. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Source

Kakiuchi N.,University of Miyazaki | Atsumi T.,University of Miyazaki | Higuchi M.,University of Miyazaki | Kamikawa S.,University of Miyazaki | And 9 more authors.
Journal of Natural Medicines

Aconite tuber is a representative crude drug for warming the body internally in Japanese Kampo medicine and Chinese traditional medicine. The crude drug is used in major prescriptions for the aged. Varieties of Aconitum plants are distributed throughout the Japanese Islands, especially Hokkaido. With the aim of identifying the medicinal potential of Aconitum plants from Hokkaido, 107 specimens were collected from 36 sites in the summer of 2011 and 2012. Their nuclear DNA region, internal transcribed spacer (ITS), and aconitine alkaloid contents were analyzed. Phylogenic analysis of ITS by maximum parsimony analysis showed that the majority of the specimens were grouped into one cluster (cluster I), separated from the other cluster (cluster II) consisting of alpine specimens. The aconitine alkaloid content of the tuberous roots of 76 specimens showed 2 aspects - specimens from the same collection site showed similar aconitine alkaloid profiles, and cluster I specimens from different habitats showed various alkaloid profiles. Environmental pressure of each habitat is presumed to have caused the morphology and aconitine alkaloid profile of these genetically similar specimens to diversify. © 2014 The Japanese Society of Pharmacognosy and Springer Japan. Source

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