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Nagoya-shi, Japan

Hara Y.,Nagoya University | Fujii T.,Nagoya University | Kashida H.,Nagoya University | Sekiguchi K.,Nagoya University | And 6 more authors.
Angewandte Chemie - International Edition | Year: 2010

(Figure Presented) Excitonic interaction was utilized to design a highly sensitive in-stem molecular beacon (ISMB) in which both a fluorophore and a quencher on D-threoninols are incorporated as a pseudo base pair (see scheme; optimized combination with Cy3 and modified Methyl Red). Minimization of the difference between λmax of the fluorophore and quencher maximized quenching efficiency. © 2010 Wiley-VCH Verlag GmbH S. Co. KCaA Weinheim. Source


Asanuma H.,Nagoya University | Asanuma H.,Innovative Research Center for | Osawa T.,Nagoya University | Kashida H.,Nagoya University | And 8 more authors.
Chemical Communications | Year: 2012

In the presence of poly(l-lysine)-graft-dextran, an in-stem molecular beacon involving three perylene-anthraquinone pairs in the stem region had a signal/background ratio of as high as 570. Response speed was also remarkable; equilibrium was attained within 5 minutes after addition of substrate DNA at 20°C. © 2012 The Royal Society of Chemistry. Source

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