Research Center for Health science

Shīrāz, Iran

Research Center for Health science

Shīrāz, Iran

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Dianatinasab M.,Shiraz University of Medical Sciences | Ghaem H.,Research Center for Health science | Rezaianzadeh A.,Research Center for Health science | Rezaianzadeh A.,Shiraz University of Medical Sciences | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2016

Background: Mortality among Iranian patients with colorectal cancer has not been fully examined and the factors associated with their survival are still controversial. This study aimed to determine the mortality rate and its related factors among the patients with colorectal cancer in southwestern regions in Iran. Materials and Methods: This prospective cohort study was conducted on 220 patients with colorectal cancer referred to Fahighi Hospital, Shiraz, Iran from 2009 to 2014. Data were collected from the patients' medical records and were analyzed using Cox regression analysis. Results: Over a median follow-up of 29.3 months, 56 out of the 220 patients (25.5%) died, 32 (14.5%) aged below 40 years, and 45.5% were female. Based on the results of multiple Cox regression analysis, family history of gastrointestinal cancer, stage III, former smoking, type of lesion (fungative and polypoid), and opium use were associated with a greater risk of colorectal cancer mortality (all P < 0.05). Conclusions: This cohort study found that the mortality rate of colorectal cancer in Iran is lower than that in European countries. In addition, behavioral and clinical factors were significantly associated with the survival rate. Addressing the related factors would help healthcare providers and physicians provide the best care and improve the survival rate.


Costa A.M.,University of Beira Interior | Costa A.M.,Center for Research in Sport | Breitenfeld L.,University of Beira Interior | Breitenfeld L.,Research Center for Health science | And 7 more authors.
Sports Medicine | Year: 2012

Top-level sport seems to play a natural Darwinian stage. The most outstanding athletes appear to emerge as a result of exogenous influences of nature andor coincidence, namely, the contingency of practicing certain sport for which their talents best fit. This coincidence arises because certain individuals possess anatomical, metabolic, functional and behavioural characteristics that are precisely those required to excel in a given sport. Apart from the effects of training, there is strong evidence of genetic influence upon athletic performance. This article reviews the current state of knowledge regarding heritable genetic effects upon endurance and muscle strength, as reported by several twin and family studies. Due, probably, to the inaccuracy of the measurement procedures and sampling error, heritability estimates differ widely between studies. Even so, the genetic inheritence effects seem incontrovertible in most physical traits: ∼4070 for peak oxygen uptake and cardiac mass and structure, and ∼3090 for anaerobic power and capacity, ranging according to the metabolic category. Studies in development by several researchers at this present time seem to guarantee that future reviews will include twins and family studies concerning genes associated with the adaptive processes against hormetic agents, such as exercise, heat and oxidative stress. © 2012 Springer International Publishing AG. All rights reserved.


Rezaianzadeh A.,Research Center for Health science | Talei A.,Shiraz University of Medical Sciences | Rajaeefard A.,Research Center for Health science | Hasanzadeh J.,Research Center for Health science | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012

Introduction: Identification of simple and measurable prognostic factors is an important issue in treatment evaluation of breast cancer. The present study was conducted to evaluate the prognostic role of vascular invasion in lymph node negative breast cancer patients. Methods: in a retrospective design, we analyzed the recorded profiles of the 1,640 patients treated in the breast cancer department of Motahari clinic affiliated to Shiraz University of Medical Sciences, Shiraz, Iran, from January 1999 to December 2012. Overall and adjusted survivals were evaluated by the Cox proportional hazard model. All the hypotheses were considered two-sided and a p-value of 0.05 or less was considered as statistically significant. Results: Mean age in lymph node negative and positive patients was 50.0 and 49.8 respectively. In lymph node negative patients, the number of nodes, tumor size, lymphatic invasion, vascular invasion, progesterone receptor, and nuclear grade were significant predictors. In lymph node and lymphatic negative patients, vascular invasion also played a significant prognostic role in the survival which was not evident in lymph node negative patients with lymphatic invasion. Discussion: The results of our large cohort study, with long term follow up and using multivariate Cox proportional model and comparative design showed a significant prognostic role of vascular invasion in early breast cancer patients. Vascular invasion as an independent prognostic factor in lymph node negative invasive breast cancer.


Neghab M.,Research Center for Health science | Mohraz M.H.,Research Center for Health science | Hassanzadeh J.,Shiraz University of Medical Sciences
Journal of Occupational Health | Year: 2011

Purpose: The aim of this study was to ascertain whether symptoms of respiratory disorders and lung functional impairments are associated with occupational inhalation exposure to carbon black (CB) in a group of rubber workers. Methods: The study population consisted of 72 male workers with a past history of and current exposure to CB and 69, randomly selected, healthy unexposed male office workers that served as the referent group. Subjects were interviewed and given standardized respiratory symptom questionnaires to answer. Furthermore, pulmonary function tests (PFTs) were performed before and after the work shift for exposed subjects and once during the work shift for referent subjects. Furthermore, to assess the extent to which workers were exposed to CB, using standard methods, inhalable and respirable dust fractions of CB were measured in different dusty worksites. Results: The levels of exposure to inhalable and respirable CB dust were estimated to be 6.2 ± 1.7 and 2.3 ± 0.29 mg/m 3 respectively (mean ± SD). Respiratory symptom questionnaires revealed that regular cough, phlegm, wheezing and shortness of breath were significantly (p<0.05) more prevalent among exposed workers. Furthermore, significant decreases in some preshift and postshift parameters of pulmonary function of exposed workers with a spirometric pattern consistent with restrictive ventilatory disorder were found. Conclusion: The findings of this study provide circumstantial evidence to support the notion that exposure to CB exceeding its current TLV is associated with a significant increase in the prevalence of respiratory symptoms along with both acute, partially reversible and chronic irreversible significant decreases in some parameters of pulmonary function.


PubMed | Research Center For Health science
Type: Journal Article | Journal: Journal of research in health sciences | Year: 2012

Managers communication skills are one of the most important topics in educational sector of universities of medical sciences and may have considerable effect on faculty members and employees. This study was per-formed to determine the level of communication skills (verbal, listening, feed-back) of the heads of department of faculties and its relation with some demo-graphic variables.This cross-sectional study was conducted from June 2009 to January 2010. We enrolled all of the heads of departments (N=60) in Hamadan University of Medical Sciences, western Iran. The participants received a self-administered 24-item questionnaire in Likert format (six general items and 18 items related to communication skills). Data were analyzed with SPSS software using Chi-square and Fishers exact tests.The average scores of verbal, listening and feedback communication were 22.5, 16.1 and 21.1, respectively. Accordingly, 78.3% of participants in verbal communication, 16.7% in listening communication and 73.3% in feedback communication had high status. There were significant differences between the average score of listening skills and age (P=0.013) as well as gender (P=0.042). In addition, there was a significant statistical difference between verbal skills and gender (P=0.021).The overall communication skills of more than half of the heads of departments were moderate. This needs designing some programs for improving department managers communication skills.

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