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Ashok B.K.,Gujarat Ayurved University | Bhat S.D.,Muniyal Institute of Ayurveda Medical science | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2012

Effect of Euphorbia fusiformis Buch.-Ham. ex. D. Don root powder on intestinal transit time was carried out after standardizing the kaolin expulsion test by administering 40% kaolin to overnight fasted Swiss albino mice. Evaluation on intestinal transit time was carried out by using this standard procedure by administering the drug at 130 mg/kg and 260 mg/kg doses. E. fusiformis root powder significantly shortened the duration required for the expulsion of kaolin in dose dependant manner. The study shows that the root powder of E. fusiformis possesses significant intestinal motility enhancing effect, the exact mechanism of which needs to be elucidated.

Deole Y.S.,G J Patel Institute of Ayurvedic Studies and Research | Ashok B.K.,Himalaya | Chavan S.S.,Institute for Post Graduate Teaching | Ravishankar B.,Research Center for Ayurveda and Allied science | And 2 more authors.
Indian Journal of Natural Products and Resources | Year: 2013

Distress is one of the most dangerous epidemics having potential to cause severe somatic and psychiatric disorders. Rasayana (rejuvenation therapy) drugs in Ayurveda can be an answer to prevent stress induced disorders. Rasayana powder, an Ayurvedic formulation, is used for health promoting and anti-ageing benefits. The present study was conducted to evaluate the adaptogenic and antiulcer potency of Rasayana Ghana tablet (RGT) in experimental animals in reverse pharmacological approach. Charles Foster strain albino rats of either sex were divided into five groups and treated as Water control, Stress control, Ghee and Honey treated (Vehicle control), RGT with vehicle control and Standard control. All the animals were subjected to pharmacological protocol of forced swimming stress. RGT was administered along with vehicle in the dose of 180 mg/kg orally for 7 consecutive days before subjecting to stress. The adaptogenic and anti-ulcer activities were assessed on the basis of changes in rectal temperature, body weight, ulcer index, haematological parameters and antioxidant activities. In forced swimming hypothermia, pre-treatment with RGT caused significant attenuation of rectal temperature when compared with both stress control group. The RGT showed significant attenuation on stress induced gastric ulcers by quenching free radicals. Further it significantly prevented stress induced leucopenia. Thus, it can be concluded that RGT along with ghee and honey as vehicle possess anti-stress and adaptogenic activity.

Bhat S.D.,Gujarat Ayurved University | Ashok B.K.,Gujarat Ayurved University | Acharya R.,Gujarat Ayurved University | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2012

The rhizomes of Vacha (Acorus calamus Linn.) have been used in Ayurvedic medicine for the treatment of various ailments. Ayurvedic pharmacopoeia of India has advocated Shodhana (Purification) procedure to be done prior to its use. Hence in the present study comparative oral acute toxicity of raw and classically processed Vacha rhizome was undertaken to provide safety profile on acute administration. The rhizomes were collected from wild source and Shodhana procedure was done as mentioned in the Ayurvedic texts. Acute toxicity test was evaluated as per OECD 425 guidelines with 2000mg/kg as limit test. Test drugs were administered orally to overnight fasted female rats and detailed behavioural profiles were recorded throughout the study. Change in body weight, haematological and biochemical parameters were carried out on 14th day. At 2000 mg/kg dose both raw and classically processed Vacha did not produce any observable toxic effects and all animals survived 14 days of observation.

Jagtap M.,Gujarat Ayurved University | Ashok B.K.,Gujarat Ayurved University | Chavan S.S.,Gujarat Ayurved University | Chandola H.M.,Gujarat Ayurved University | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2011

The present study was undertaken to evaluate cardioprotective activity of Makandi (Coleus forskohli Willd.) Churna and Ghanavati on the basis of electrocardiographic, biochemical, cardiac output and histopathological parameters against isoproterenol (ISO) induced myocardial infarction in diet induced hyperlipidaemic rats. The drug treatment and hyperlipidaemic diets were administered for 20 consecutive days. Myocardial injury was induced by injecting ISO (85 mg/kg) to rats at an interval of 24 h for two days. Forty eight hours after the first dose of ISO injection, parameters like ECG, cardiac output, biochemical and histological observations of the heart tissues were performed. Hyperlipidaemic diet followed by ISO significantly increased heart weight, altered serum lipid profiles, SGPT and ALP activity, caused ST segment elevation, prolonged QT interval and QTc in ECG, increased blood pressure and decreased cardiac output. Histopathologically also, heart showed severe cytoarchitectural disturbances like myonecrosis, fatty changes and endocardial oedema. When administered orally, both the formulations of Makandi decreased atherogenic index, almost normalized ST segment elevation, QT interval prolongation and cardiac output. Histopathologically also remarkable protection was observed. Analysis of the results showed that Makandi in Churna form has both anti-atherogenic potentia l and cardioprotective activity, while Ghanavti has only weak cardioprotective activity.

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