Research Center for Ayurveda and Allied science

Udipi, India

Research Center for Ayurveda and Allied science

Udipi, India
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Sharma R.,Gujarat Ayurved University | Kumar V.,Pharmacology Laboratory | Ashok B.K.,Pharmacology Laboratory | Galib R.,Gujarat Ayurved University | And 2 more authors.
International Journal of Green Pharmacy | Year: 2013

Background: Diabetes mellitus is a common endocrine disorder, characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. Ayurvedic herbs are relatively low cost, more suitable and have negligible side-effects than synthetic oral anti-hyperglycaemic agents. Guduchi is reported as highly potent anti-diabetic herb in Ayurveda and Guduchi Ghanavati is popularly known by the Ayurvedic fraternity for its therapeutic properties on Madhumeha represented as diabetes mellitus. Aim: The aim of this study is to evaluate hypoglycaemic and anti-hyperglycaemic activities of Guduchi Ghana (GG) in Swiss albino mice. Materials and Methods: Hypoglycaemic and anti-hyperglycaemic potential of GG was evaluated in normal mice using both 18 h fasted mice model and oral glucose tolerance test. GG was suspended in distilled water and administered to animals at the dose of 130 mg/kg. Statistical Analysis: The results were statistically interpreted using Student′s ′t′- test for paired and unpaired data to assess the statistical significance and the significant level was set at P < 0.05. Results: GG showed mild reduction in blood sugar level (BSL) at all the time intervals in normoglycaemic mice. In anti-hyperglycaemic activity, glibenclamide at a dose of 0.65 mg/kg studied as the reference standard to compare the potency of test drug. Administration of GG prior to glucose over load resulted significant attenuation in BSL at 60 min, 90 min and 120 min in comparison to glucose control group. Conclusions: GG has mild hypoglycaemic and significant anti-hyperglycaemic activity and can be used in the treatment of diabetes mellitus as well as a supportive drug without fear of producing hypoglycaemia.

Sharma M.,SDM Ayurveda Hospital | Ravishankar B.,Research Center for Ayurveda and Allied science | Mundugaru R.,Research Center for Ayurveda and Allied science
Journal of Ayurveda and Integrative Medicine | Year: 2017

Background A suture material producing least tissue reaction is considered as ideal. Other characteristics like tensile strength, capacity to sustain sterilization process enhance its acceptability. In the present situation there is a need to reascertain the relevance and utility of these materials. Among the suture materials mentioned by Sushrutacharya, Moorva (Sansevieria roxburghiana) and Shana (Crotalaria pallida) have been showed insignificant tissue reaction in operated cases of inguinal hernia. An experimental study to confirm the extent of tissue reaction in deeper planes is needed before extending the use of materials in the deep tissues. Objective The objective of the study was to analyze deep tissue reaction and tensile strengths of plant fibres extracted from Crotalaria pallida and Sansevieria roxburghiana. Materials and methods The study was conducted on 18 albino rats, 3 groups of 6 rats each for a period of 21 days inserting the suture materials in deeper tissue, studying histopathology changes of the deeper connective tissues, hydroxyproline content and blood parameters on 7th, 14th, 21st days of the study. The tensile strength of the two materials was also assessed on 7th day in three different conditions. Statistical analysis was carried out using paired and unpaired t tests. Results S. roxburghiana had least tissue reaction. C. pallida showed greater tensile strength in comparison to Moorva. Conclusion C. pallida can be used for deep tissue approximation because of its moderate tissue reaction and tensile strength, successive increase in hydroxyproline content and its capacity to sustain sterilization. © 2016 Transdisciplinary University, Bangalore and World Ayurveda Foundation

Ashok B.K.,Gujarat Ayurved University | Bhat S.D.,I.P.G.T. and R.A | Shukla V.J.,A And G Pharmaceutical, Inc. | Ravishankar B.,Research Center for Ayurveda and Allied science
Pharmacognosy Journal | Year: 2011

The present investigation was undertaken to analyze the physicochemical and chromatographic profile of dried tuberous roots of Euphorbia fusiformis. Physicochemical parameters like loss on drying, total ash value, acid insoluble ash, water insoluble ash, various extractive values, pH etc., were carried out. Further, qualitative tests for various functional groups like alkaloids, glycosides etc., were carried out in methanol and water extracts. The results of the preliminary phytochemical screening indicated the presence of carbohydrates, starch, flavanoids and steroids. Thin layer chromatography was carried out using different solvent systems which revealed two common spots indicating the presence of some common phyto-constituents. The parameters of present study can be used as a reference for further scientific investigations.

Bhat S.D.,Gujarat Ayurved University | Ashok B.K.,Gujarat Ayurved University | Acharya R.,Gujarat Ayurved University | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2012

The rhizomes of Vacha (Acorus calamus Linn.) have been used in Ayurvedic medicine for the treatment of various ailments. Ayurvedic pharmacopoeia of India has advocated Shodhana (Purification) procedure to be done prior to its use. Hence in the present study comparative oral acute toxicity of raw and classically processed Vacha rhizome was undertaken to provide safety profile on acute administration. The rhizomes were collected from wild source and Shodhana procedure was done as mentioned in the Ayurvedic texts. Acute toxicity test was evaluated as per OECD 425 guidelines with 2000mg/kg as limit test. Test drugs were administered orally to overnight fasted female rats and detailed behavioural profiles were recorded throughout the study. Change in body weight, haematological and biochemical parameters were carried out on 14th day. At 2000 mg/kg dose both raw and classically processed Vacha did not produce any observable toxic effects and all animals survived 14 days of observation.

Deole Y.S.,G J Patel Institute of Ayurvedic Studies and Research | Ashok B.K.,Himalaya | Chavan S.S.,Institute for Post Graduate Teaching | Ravishankar B.,Research Center for Ayurveda and Allied science | And 2 more authors.
Indian Journal of Natural Products and Resources | Year: 2013

Distress is one of the most dangerous epidemics having potential to cause severe somatic and psychiatric disorders. Rasayana (rejuvenation therapy) drugs in Ayurveda can be an answer to prevent stress induced disorders. Rasayana powder, an Ayurvedic formulation, is used for health promoting and anti-ageing benefits. The present study was conducted to evaluate the adaptogenic and antiulcer potency of Rasayana Ghana tablet (RGT) in experimental animals in reverse pharmacological approach. Charles Foster strain albino rats of either sex were divided into five groups and treated as Water control, Stress control, Ghee and Honey treated (Vehicle control), RGT with vehicle control and Standard control. All the animals were subjected to pharmacological protocol of forced swimming stress. RGT was administered along with vehicle in the dose of 180 mg/kg orally for 7 consecutive days before subjecting to stress. The adaptogenic and anti-ulcer activities were assessed on the basis of changes in rectal temperature, body weight, ulcer index, haematological parameters and antioxidant activities. In forced swimming hypothermia, pre-treatment with RGT caused significant attenuation of rectal temperature when compared with both stress control group. The RGT showed significant attenuation on stress induced gastric ulcers by quenching free radicals. Further it significantly prevented stress induced leucopenia. Thus, it can be concluded that RGT along with ghee and honey as vehicle possess anti-stress and adaptogenic activity.

Ashok B.K.,Gujarat Ayurved University | Bhat S.D.,Muniyal Institute of Ayurveda Medical science | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2012

Effect of Euphorbia fusiformis Buch.-Ham. ex. D. Don root powder on intestinal transit time was carried out after standardizing the kaolin expulsion test by administering 40% kaolin to overnight fasted Swiss albino mice. Evaluation on intestinal transit time was carried out by using this standard procedure by administering the drug at 130 mg/kg and 260 mg/kg doses. E. fusiformis root powder significantly shortened the duration required for the expulsion of kaolin in dose dependant manner. The study shows that the root powder of E. fusiformis possesses significant intestinal motility enhancing effect, the exact mechanism of which needs to be elucidated.

Jagtap M.,Gujarat Ayurved University | Ashok B.K.,Gujarat Ayurved University | Chavan S.S.,Gujarat Ayurved University | Chandola H.M.,Gujarat Ayurved University | Ravishankar B.,Research Center for Ayurveda and Allied science
Indian Journal of Natural Products and Resources | Year: 2011

The present study was undertaken to evaluate cardioprotective activity of Makandi (Coleus forskohli Willd.) Churna and Ghanavati on the basis of electrocardiographic, biochemical, cardiac output and histopathological parameters against isoproterenol (ISO) induced myocardial infarction in diet induced hyperlipidaemic rats. The drug treatment and hyperlipidaemic diets were administered for 20 consecutive days. Myocardial injury was induced by injecting ISO (85 mg/kg) to rats at an interval of 24 h for two days. Forty eight hours after the first dose of ISO injection, parameters like ECG, cardiac output, biochemical and histological observations of the heart tissues were performed. Hyperlipidaemic diet followed by ISO significantly increased heart weight, altered serum lipid profiles, SGPT and ALP activity, caused ST segment elevation, prolonged QT interval and QTc in ECG, increased blood pressure and decreased cardiac output. Histopathologically also, heart showed severe cytoarchitectural disturbances like myonecrosis, fatty changes and endocardial oedema. When administered orally, both the formulations of Makandi decreased atherogenic index, almost normalized ST segment elevation, QT interval prolongation and cardiac output. Histopathologically also remarkable protection was observed. Analysis of the results showed that Makandi in Churna form has both anti-atherogenic potentia l and cardioprotective activity, while Ghanavti has only weak cardioprotective activity.

PubMed | Himalaya, Research Center for Ayurveda and Allied science and Government Ayurvedic College
Type: Journal Article | Journal: Ayu | Year: 2014

Lepidium sativum Linn. (Chandrashura) of Family Cruciferae (Brassicaceae) is being used by the people of Gujarat for treating inflammatory condition like arthritis. To evaluate its anti-inflammatory activity, Charles Foster albino rats were selected and experiments were carried out in three groups, therapeutic dose group, twice of therapeutic dose group and control group. In Carrageenan-induced paw oedema, the test drug produced moderate anti-inflammatory activity; however, the effect did not show statistically significant activity due to variation in the data of the control group. In formaldehyde-induced paw oedema in rats, the test drug produced moderate to significant suppression. This indicates that Chandrashura has a strong inhibitory effect on proliferation of fibroblasts and also probably has connective tissue modulation effect.

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