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Pena E.,Aragon Institute of Engineering Research | Pena E.,Research Center Biomedica en Red en Bioingenieria
Mechanics Research Communications | Year: 2011

Several typical equations for damage variables are proposed in the literature in the context of Continuum Damage Mechanics for fibred materials such as soft biological tissues. All these proposed functions are defined for the same or similar soft tissues. The applicability of some of them, however, is not clear. The paper compares a series of damage functions given in the literature for the description of softening in soft biological tissues. In addition, a new damage function is introduced. The difference in the response of this function compared to those previously proposed in the literature is that the first derivative is zero at the initial damage state. This represents a potential advantage with respect to numerical calculations since smooth derivatives are obtained. © 2011 Elsevier Ltd. All rights reserved. Source


Izquierdo-Serra M.,Institute Of Bioenginyeria Of Catalonia | Gascon-Moya M.,Autonomous University of Barcelona | Hirtz J.J.,Columbia University | Pittolo S.,Institute Of Bioenginyeria Of Catalonia | And 10 more authors.
Journal of the American Chemical Society | Year: 2014

Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these molecules. Here we demonstrate two-photon excitation of azobenzene-based protein switches and versatile strategies to enhance their photochemical responses. This enables new applications to control the activation of neurons and astrocytes with cellular and subcellular resolution. © 2014 American Chemical Society. Source


Laguna P.,Aragon Institute of Engineering Research | Laguna P.,Research Center Biomedica en Red en Bioingenieria | Sornmo L.,Lund University
Journal of Electrocardiology | Year: 2014

The development of new techniques for detection and characterization of transient myocardial ischemia has benefited considerably from the STAFF III database, acquired in patients receiving elective prolonged percutaneous transluminal coronary angiography. The present article reviews a range of techniques developed and/or evaluated on the ECG signals of this database, including techniques for exploring abnormal intra-QRS potentials, QRS slopes, QRS angles, T wave morphology, T wave alternans, spatiotemporal ECG information, as well as heart rate dynamics. The detection of changes in body position is also briefly reviewed as it is intimately related to ischemia detection. © 2014 Elsevier Inc. Source


Prieto-Simon B.,Institute for Bioengineering of Catalonia IBEC | Prieto-Simon B.,Research Center Biomedica en Red en Bioingenieria | Prieto-Simon B.,University of South Australia | Samitier J.,Institute for Bioengineering of Catalonia IBEC | And 2 more authors.
Analytical Chemistry | Year: 2014

A novel sensing strategy for electrochemical aptamer-based sensors is presented. Nucleic acid aptamers are considered alternatives to antibodies. However, some of their intrinsic properties, such as that they can undergo conformational changes during the binding of the target, can be used to design novel sensing strategies. Unlike other electrochemical "signal off" aptamer-based sensors, we report a strategy based on enzymatic inhibition. Our approach shows the feasibility to detect small molecules based on the aptamer conformational change induced by the target that leads to the inhibition of the enzyme used as a label. Additionally, we prove the ability to regenerate the function of the aptasensor by simply applying a short potential pulse. As a proof-of-concept, the widely used aptamer for ochratoxin A (OTA) has been selected as a model. After self-assembling short oligonucleotides onto a gold electrode, complementary to the 3′ end of the aptamer, hybridization of the aptamer takes place. To investigate the mechanism induced by the OTA-binding, surface plasmon resonance assays were performed, which confirmed the conformational switch of the aptamer rather than the aptamer displacement by dehybridization from the DNA-modified sensor surface. The electrochemical sensor can successfully detect OTA in wine at the limits stipulated by the European Commission. Given its sensitivity, rapid and easy detection, and regeneration, it can be envisaged as screening tool for OTA detection. Moreover, this sensing strategy has the potential to be applied to other aptamer-based biochemical assays for the detection of small molecules in the fields of food safety, environmental monitoring, and medical diagnostics. © 2013 American Chemical Society. Source


Rojas S.,Institute Dalta Tecnologia Parc Of Recerca Biomedica Of Barcelona | Gispert J.D.,Institute Dalta Tecnologia Parc Of Recerca Biomedica Of Barcelona | Gispert J.D.,Research Center Biomedica en Red en Bioingenieria | Martin R.,Polytechnic University of Valencia | And 8 more authors.
ACS Nano | Year: 2011

Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to confirm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled nanodiamonds with 18F to study their in vivo biodistribution by positron emission tomography. Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen, and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to significant changes in this pattern, with the exception of a slight reduction in the urinary excretion rate. On the other hand, after filtration of the radiolabeled diamond nanoparticles to remove those with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and significantly reduced in the liver. © 2011 American Chemical Society. Source

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