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Aldana-Llanos L.,National Polytechnic Institute of Mexico | Salinas-Sanchez D.O.,University of Central Mexico | Valeds-Estrada Ma.E.,National Polytechnic Institute of Mexico | Gutirrez-Ochoa M.,National Polytechnic Institute of Mexico | And 2 more authors.
Southwestern Entomologist

The bioinsecticidal activity of organic extracts of Tagetes erecta L. on L1 larvae of fall armyworm, Spodoptera frugiperda (E. Smith), was evaluated. The acetonic extract of the leaves (500 ppm) of T. erecta exhibited an antifeedant effect, causing 50% reduction in larval weight in comparison with that of the check. Information obtained on larval weight at 7 days corroborated with results obtained at 14 days when T. erecta extracts killed most larvae. The following killed the most larvae: n-hexane leaf (48%), acetone leaf (60%), and ethanol leaf, which caused most larval mortality of 72%. T. erecta leaf extracts were toxic to 4080% of the pupae. The leaf extracts hexane, acetone, and ethanol of T. erecta killed many larvae and were evaluated at different concentrations: 125, 250, 750, and 1,000 ppm. The LC50 for n-hexano leaf extract was 312.2 ppm (X 2 = 0.1102); for acetone leaf extract of T. erecta, 246.9 ppm (X 2 = 0.1598), and for ethanol leaf extract, 152.2 ppm (X 2 = 0.1504), with a 95% confidence. Thus, use of these extracts is suggested as a more environmentally friendly alternative to combat insect pests of maize, Zea mays L. Source

Leos-Rivas C.,Autonomous University of Nuevo Leon | Verde-Star M.J.,Autonomous University of Nuevo Leon | Torres L.O.,Research Center Biomedica del Sur | Oranday-Cardenas A.,Autonomous University of Nuevo Leon | And 4 more authors.
Journal of Medicinal Food

Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC 50) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC 50 of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection. © 2011, Mary Ann Liebert, Inc. Source

Leon-Rivera I.,Autonomous University of the State of Morelos | Castro J.M.,Autonomous University of the State of Morelos | Miron-Lopez G.,Autonomous University of Yucatan | Del Rio-Portilla F.,National Autonomous University of Mexico | And 8 more authors.
Journal of Natural Medicines

The methanol-soluble extract from the root of Ipomoea tyrianthina was studied in order to isolate compounds with activity on the central nervous system and vasorelaxant effects. Chromatographic methods were used to isolate and purify seven new glycolipids (2-8). The structures of compounds 1-8 were elucidated by a combination of NMR spectroscopy and mass spectrometry. Tyrianthinoic acid (1) is a glycosidic acid composed of a linear pentasaccharide core bonded to a 11-hydroxyhexadecanoic acid. The structure of tyrianthinic acids III (2), IV (3), and V (4) consists of a partially acylated tyrianthinoic acid. Tyrianthinic acid VI (8) is a tetrasaccharide core bonded to a jalapinolic acid, acylated by a 2-methyl-3-hydroxybutanoic acid. Tyrianthins C (5), D (6), and E (7) are ester-type heterodimers of scammonic acid A with different acylating residues in the two monomeric units. The macrolactonization site was located at C-3 of the rhamnose unit. The position of the ester linkage for monomeric unit B on the macrocyclic unit A was established at C-4 of the terminal quinovose. Compounds 5-7 increased the sleeping time induced by pentobarbital and the release of gamma-aminobutyric acid in brain cortex. In addition, compounds 5-7 showed significant in vitro relaxant effects on aortic rat rings, in endothelium- and concentration-dependent manners. © 2014 The Japanese Society of Pharmacognosy and Springer Japan. Source

Lombardo-Earl G.,Metropolitan Autonomous University | Lombardo-Earl G.,Research Center Biomedica del Sur | Roman-Ramos R.,Metropolitan Autonomous University | Zamilpa A.,Research Center Biomedica del Sur | And 4 more authors.
Evidence-based Complementary and Alternative Medicine

Sechium edule is traditionally used in Mexico as a therapeutic resource against renal diseases and to control high blood pressure. The purpose of this work is to evaluate the antihypertensive effect of the hydroalcoholic extract obtained from the roots of this plant, including its fractions and subfractions, on different hypertension models induced with angiotensin II (AG II). The hydroalcoholic extract was tested on an in vitro study of isolated aorta rings denuded of endothelial cells, using AG II as the agonist; this assay proved the vasorelaxant effect of this extract. Vagotomized rats were administered different doses of AG II as well as the Hydroalcoholic extract, which reduced blood pressure in 30 mmHg approximately; subsequently this extract was separated into two fractions (acetone and methanol) which were evaluated in the acute hypertension mouse model induced with AG II, where the acetone fraction was identified as the most effective one and was subsequently subfractioned using an open chromatographic column packed with silica gel. The subfractions were also evaluated in the acute hypertension model. Finally, the extract, fraction, and active subfraction were analyzed by MS-PDA-HPLC, identifying cinnamic derivative compounds like cinnamic acid methyl ester. © 2014 Galia Lombardo-Earl et al. Source

Dominguez-Patino M.L.,Autonomous University of the State of Morelos | Chavez-Castillo M.,Autonomous University of the State of Morelos | Rodriguez-Martinez A.,Autonomous University of the State of Morelos | Melgoza Aleman R.M.,Autonomous University of the State of Morelos | And 2 more authors.
Materials Research Society Symposium Proceedings

In the last fifteen years, there have been significant changes in the production of medicines, mainly in the addition of new components to the formulation of solid dosage forms. The current trend of "back to nature" to lead to a healthier life has led those who are engaged in the pharmaceutical field to develop new formulations that allow the use of natural products of plant origin. For example, excipient ingredients, used as carriers for a drug's active ingredients, are now being used. These are incorporated into a drug in order to facilitate the drug's preparation, maintenance, or administration. The excipient is beneficial to the patient because it allows the drug to be easily administered and absorbed by the human body [3]. There is evidence that the clays have great potential for both absorption and adsorption due to its tiny particles. In addition, it has been reported that some clays have an effective antiseptic and healing ability [5-8]. In the present work, a clay called bentonite was tested as a support vehicle of an inflammatory agent derived from a Mexican native plant called Distictis buccinatoria, commonly named "Tonacaxóchitl". Studies carried out by Rojas et al. have shown that the organic extract of this plant has important antibacterial, antifungal, cytotoxic and anti-inflammatory properties [9]. © Materials Research Society. Source

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