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News Article | February 16, 2017
Site: www.eurekalert.org

Leading neuroscience researchers and scholars from across New York will gather for the inaugural SUNY-CUNY Neuroscience Research Forum on Thursday, February 23, 2017, from 9:30 A.M. to 4:15 P.M. The forum will be held in the D'Ambra Auditorium at the Life Sciences Research Building on the Uptown Campus at the University at Albany. The State University of New York (SUNY) and the City University of New York (CUNY) are home to leading public research universities deeply committed to work that addresses state and global challenges. In service of this mission, the SUNY-CUNY Neuroscience Research Forum, a brainchild of Drs. James Dias, Vice President for Research at UAlbany and Mark Hauber, Interim Vice Provost for Research at CUNY Central, seeks to foster faculty collaborations and research synergies across the state of New York, and to spur multi-investigator, large-scale, and multi-institutional extramural funding pursuits in neuroscience. Prof. Yasmin Hurd, a nationally acclaimed researcher on addiction and related psychiatric disorders from the Icahn School of Medicine at Mount Sinai, will present the keynote address and discuss her pioneering new research on the transgenerational effects of cannabis on the developing brain. This keynote will be followed by break-out sessions moderated by SUNY and CUNY Vice Presidents, Vice Provosts, and Deans of Research and Science. Specifically, the SUNY-CUNY Neuroscience Research Forum will convene interdisciplinary, thematically-based group discussions, afford opportunities to share research interest along with current and planned endeavors, enable networking and collaborative interactions, and conclude with a plenary session to summarize Forum activities and to discuss future collaborative opportunities in neuroscience research among SUNY, CUNY and other neuroscience colleagues. Alexander N. Cartwright, SUNY Provost, and Executive Vice Chancellor said, "This is such an important endeavor and my sincere thanks go to the SUNY, CUNY and state-wide participants. Together we can make life-changing advances in neuroscience research and discovery that go well beyond what one institution can do alone. This type of collaboration underscores New York State's capacity for leadership in the field." Mark Hauber, Interim Vice Provost for Research at CUNY noted: "Neuroscience by definition is an interdisciplinary field that needs to bring together researchers from diverse fields for success. Focusing on neuroscience as part of ongoing initiatives for SUNY-CUNY collaborations brings our diverse faculty and student talents together to increase extramural funding and high-impact productivity of research at New York State's public university systems." UAlbany Vice President for Research James A. Dias said, "Neuroscience in the 21st century is clearly in the midst of a seismic transformation with an unprecedented focus on multi-investigator, interdisciplinary collaborative research strategies aimed at overcoming some of today's most complex and perplexing scientific challenges. This is why I could not be more pleased that the University at Albany is hosting the first ever SUNY-CUNY Neuroscience Research Forum bringing faculty scholars and scientists together to forge new research collaborations and spark novel extramural funding pursuits in search of the next scientific breakthrough to improve the health and well-being of society." Hosted on the UAlbany campus, one of the four distinguished SUNY University Centers, the SUNY-CUNY Neuroscience Research Forum will be held in the D'Ambra Auditorium of the 194,000-square-foot, state-of-the-art Life Sciences Research Building - home to a number of UAlbany's top neuroscience researchers. The founding members of the SUNY-CUNY Neuroscience Research Forum include the State University of New York, the City University of New York Office of Research, SUNY Downstate Medical Center, SUNY Optometry, and the University at Albany. Both Research Foundations of SUNY and CUNY are participating in this effort. Faculty and industry partners from more than 15 SUNY, CUNY and independent universities and colleges will be participating in the event. SUNY is the largest comprehensive system of higher education in the United States, with 64 college and university campuses located within 30 miles of every home, school, and business in the state. In 2015-16, SUNY served nearly 1.3 million students, including nearly 600,000 in credit-bearing courses and programs and more than 700,000 through continuing education and community outreach programs. For more information, please visit http://www. . The City University of New York is the nation's largest and leading urban public university. Founded in New York City in 1847, the University comprises 24 institutions: 11 senior colleges, seven community colleges, and additional professional and graduate schools. The University serves nearly 275,000 degree-credit students and 218,083 adults, continuing and professional education students. For more information, please visit: http://www. A comprehensive public research university, the University at Albany offers more than 120 undergraduate majors and minors and 125 master's, doctoral, and graduate certificate programs. UAlbany is a leader among all New York State colleges and universities in such diverse fields as atmospheric and environmental sciences, business, criminal justice, emergency preparedness, engineering and applied sciences, informatics, public administration, social welfare, and sociology taught by an extensive roster of faculty experts. It also offers expanded academic and research opportunities for students through an affiliation with Albany Law School. With a curriculum enhanced by 600 study-abroad opportunities, UAlbany launches great careers. For more information on CUNY research, please contact Shante Booker (shante.booker@cuny.edu) or visit: http://www. For more information on SUNY Research, please contact Holly Liapis 518-320-1311 or visit: http://www.


Sharma M.,Research Building | Halligan B.D.,Medical College of Wisconsin | Wakim B.T.,Medical College of Wisconsin | Savin V.J.,Medical College of Wisconsin | And 6 more authors.
Health Physics | Year: 2010

Victims of nuclear accidents or radiological terrorism are likely to receive varying doses of ionizing radiation inhomogeneously distributed over the body. Early biomarkers may be useful in determining organ-specific doses due to total body irradiation (TBI) or partial body irradiation. The authors used liquid chromatography and mass spectrometry to compare the effect of TBI and local kidney irradiation (LKI) on the rat urine proteome using a single 10-Gy dose of x-rays. Both TBI and LKI altered the urinary protein profile within 24 h with noticeable differences in gene ontology categories. Some proteins, including fetuin-B, tissue kallikrein, beta-glucuronidase, vitamin D-dependent calcium binding protein and chondroitin sulfate proteoglycan NG2, were detected only in the TBI group. Some other proteins, including major urinary protein-1, RNA binding protein 19, neuron navigator, Dapper homolog 3, WD repeat and FYVE domain containing protein 3, sorting nexin-8, ankycorbin and aquaporin were detected only in the LKI group. Protease inhibitors and kidney proteins were more abundant (fraction of total scans) in the LKI group. Urine protein (Up) and creatinine (Uc) (Up/Uc) ratios and urinary albumin abundance decreased in both TBI and LKI groups. Several markers of acute kidney injury were not detectable in either irradiated group. Present data indicate that abundance and number of proteins may follow opposite trends. These novel findings demonstrate intriguing differences between TBI and LKI, and suggest that urine proteome may be useful in determining organ-specific changes caused by partial body irradiation. © 2010 Health Physics Society.


Bailey D.,Incisive Media | Carpenter E.P.,Research Building | Coker A.,Center for Amyloidosis and Acute Phase Proteins | Coker S.,Center for Amyloidosis and Acute Phase Proteins | And 13 more authors.
Acta Crystallographica Section D: Biological Crystallography | Year: 2012

The analysis reported here describes detailed structural studies of endothiapepsin (the aspartic proteinase from Endothia parasitica), with and without bound inhibitors, and human pepsin 3b. Comparison of multiple crystal structures of members of the aspartic proteinase family has revealed small but significant differences in domain orientation in different crystal forms. In this paper, it is shown that these differences in domain orientation do not necessarily correlate with the presence or absence of bound inhibitors, but appear to stem at least partly from crystal contacts mediated by sulfate ions. However, since the same inherent flexibility of the structure is observed for other enzymes in this family such as human pepsin, the native structure of which is also reported here, the observed domain movements may well have implications for the mechanism of catalysis. © 2012 International Union of Crystallography Printed in Singapore - all rights reserved.


Ford researchers are slated to be embedded at the University of Michigan in a new partnership focused on autonomous driving technology development, in what the company claims is the first ever such arrangement. The partnership will see Ford researchers working directly with, and alongside of, University of Michigan researchers in the same academic building — the North Campus Research Complex (NCRC). Eventually, they will work in a state-of-the-art robotics laboratory on the University of Michigan’s Ann Arbor campus slated to open in 2020. As a reminder, Ford is currently aiming to have “fully autonomous SAE-defined level 4-capable vehicles available for high-volume commercial use in 2021.” The new partnership is part of the effort to achieve that. “Ford engineers and researchers will begin working shoulder-to-shoulder with U-M faculty and students to test and learn about autonomous vehicle technology and innovation,” stated Mark Fields, Ford president and CEO. “We are aiming to show the world what we can achieve when leaders in business and academia work together to make people’s lives better.” The press release provides more: “Ten years into the Ford–University of Michigan Innovation Alliance, the two parties have agreed Ford will lease the fourth floor of the new robotics laboratory. It is an approximately 140,000-square-foot building on Hayward Street, east of the university’s Space Research Building. The planned robotics laboratory will have space where machines walk, fly, drive, and swim. The building will house labs, offices, and classrooms, continuing a tradition of robotics leadership at U-M that includes the creation of MABEL, the world’s fastest-running robot with knees.” It certainly seems like one of the top universities for Ford to partner with in order to be on the cutting edge of autonomous driving. Continuing: “By locating a team of more than 100 employees on campus, Ford benefits from being close to technical leaders as well as facilities, such as Mcity — a one-of-a-kind urban simulation test environment in Ann Arbor. … Today, Ford and U-M also announce professors Matthew Johnson-Roberson and Ram Vasudevan will serve as leaders of a new autonomous vehicle research team comprising graduate students, postdoctoral fellows, and researchers. Both professors, who began collaborating with Ford earlier this summer, bring a wealth of autonomous vehicle research experience. Dr Johnson-Roberson is an assistant professor of Naval Architecture and Marine Engineering, and has worked in autonomous vehicles since the first DARPA Grand Challenge in 2004. His research focuses on robotic systems perception. Dr Vasudevan is an assistant professor of Mechanical Engineering with a background in robotics and next-generation automotive technologies.” Sounds like a serious research team. You can tell that Ford is serious about autonomous driving technology. Too bad it doesn’t seem to be putting the same resources into the development of a long-range electric vehicle. Or maybe it is secretly doing so behind the scenes. Buy a cool T-shirt or mug in the CleanTechnica store!   Keep up to date with all the hottest cleantech news by subscribing to our (free) cleantech daily newsletter or weekly newsletter, or keep an eye on sector-specific news by getting our (also free) solar energy newsletter, electric vehicle newsletter, or wind energy newsletter.


Shen G.,State Oceanic Administration | Shen G.,Research Building | Xia X.,State Oceanic Administration | Xia X.,Research Building | And 4 more authors.
Journal of Coastal Conservation | Year: 2015

Coastal zones, including a large number of sea islands, have experienced profound and often lasting landscape changes over the past half century. Understanding the drivers and ecological effects of these changes is a prerequisite for large-scale integrated coastal zone management (ICZM). In this study, landscape patterns of Tantoushan Island, China, for 1966, 2004, and 2012 were produced through landscape identification and classification of multi-resource remote sensing KH-7 homochromatic, QuickBird multispectral, and WorldView-2 multispectral imageries, and contemporaneous historical data. Analysis of landscape changes and drivers has shown drastic changes from 1966 to 2012, caused by afforestation, changes in exploitation methods, human-induced fire and diseases, as well as natural succession. Here, a simple weighted sum of CN values representing the runoff potential of specific landscape types from the TR-55 runoff prediction model was calculated to reflect the runoff potentials of the three different periods. The results suggest a marked fluctuation in runoff potential of Tantoushan Island from 1966 to 2012, despite an afforestation program since 1949 to optimize the vegetation structure of the island. Measures such as ecological restoration of bare land and improvement of afforestation tree species should be adopted to improve the management of Tantoushan Island. © 2015 Springer Science+Business Media Dordrecht


Latif R.,Research Building | Rejwan Ali M.,James ters Veterans Affairs Medical Center | Mezei M.,Research Building | Davies T.F.,Research Building
Endocrinology | Year: 2015

The TSH receptor (TSHR) has the propensity to form dimers and oligomers. Our data using ectodomain-truncated TSHRs indicated that the predominant interfaces for oligomerization reside in the transmembrane (TM) domain. To map the potentially interacting residues, we first performed in silico studies of the TSHR transmembrane domain using a homology model and using Brownian dynamics (BD). The cluster of dimer conformations obtained from BD analysis indicated that TM1 made contact with TM4 and two residues in TM2 made contact with TM5. To confirm the proximity of these contact residues, we then generated cysteine mutants at all six contact residues predicted by the BD analysis and performed cysteine cross-linking studies. These results showed that the predicted helices in the protomer were indeed involved in proximity interactions. Furthermore, an alternative experimental approach, receptor truncation experiments and LH receptor sequence substitution experiments, identified TM1 harboring a major region involved in TSHR oligomerization, in agreement with the conclusion from the cross-linking studies. Point mutations of the predicted interacting residues did not yield a substantial decrease in oligomerization, unlike the truncation of the TM1, so we concluded that constitutive oligomerization must involve interfaces forming domains of attraction in a cooperative manner that is not dominated by interactions between specific residues.. Copyright © 2015 by the Endocrine Society.


Trindade A.J.,Research Building | Smith M.S.,Temple University | Pleskow D.K.,Beth Israel Deaconess Medical Center
Therapeutic Advances in Gastroenterology | Year: 2015

Advanced imaging techniques used in the management of Barrett's esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett's esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric laser endomicroscopy is commercially available in the United States. Its ease of use and rapid acquisition of high-resolution images make this technology very promising for widespread application. In this article we review the technology and its potential for advanced imaging in Barrett's esophagus. © 2016 The Author(s).


Yi X.G.,Research Building | Luo C.,Research Building | Li D.,Research Building | Zhang Z.L.,Research Building
Advanced Materials Research | Year: 2012

Pressure distribution inside a fluid-conveying pipe is significant information for reasonable pipe design or mitigation of pipe vibration caused by fluid impact. Generally, a steady solution of pressure information can be obtained based on traditional CFD simulation if the inlet velocity of pipe is time independent. Unfortunately, strong oscillation of inlet velocity often happens in real engineering operations such as fuel injection or pumping process. This paper focuses on the simulation of the transient phenomenon of fluid flow inside a pipe based on the time-dependant inlet velocity. A 2D numerical pipe with an elbow is built based on Eulerian scheme and structured mesh. It is found that numerical instability occurs and convergence becomes difficult if inlet velocity presents obvious cyclic oscillation with big amplitude. Numerical oscillation increases especially when inlet velocity decreases from a big value to zero. Traditional finite volume method and cavitation model are tried and numerical results show that the convergence can be improved evidently based on cavitation model although numerical instability can not be overcome completely. © (2012) Trans Tech Publications, Switzerland.


Tong N.,McMaster University | Shmatukha A.,General Electric | Shmatukha A.,Research Building | Asmah P.,General Electric | Stainsby J.,General Electric
Physics in Medicine and Biology | Year: 2010

Various aspects of RF-induced heating of guide wires during their MRI guidance have been investigated in the past. However, the previous works focused on inducing tip heating in either fully immersed or tip-immersed (and otherwise free) wires of impractical lengths in small phantoms. This study simulates real clinical conditions using a product guide wire and a same-length conductive wire partially inserted into a torso-size phantom filled with saline solution. The purpose was to identify potential safety concerns relevant to real clinical applications, as opposed to identifying the worst-case heating scenario. Significant heating occurred at the insertion point, independent of tip heating, with a strong correlation with excitation frequency-dependent imaging parameters. Heat transfer through the wire was also demonstrated to be a safety concern. From these experiments, we have been able to demonstrate additional impacting factors that increase the complexity of safety considerations for the use of conductive guide wires during MR imaging. Safety under a particular set of conditions does not imply safety in all possible conditions that can be encountered during real MRI-guided interventions. © 2010 Institute of Physics and Engineering in Medicine.


News Article | September 16, 2016
Site: www.greencarcongress.com

« Volkswagen teases release of EV concept at Paris; production version to be 1st MEB vehicle | Main | 24M and partners awarded $3.5M from ARPA-E to develop ultra-high-energy density batteries with new lithium-metal anodes » Ford and the University of Michigan are teaming up to accelerate autonomous vehicle research and development with a first-time arrangement that embeds Ford researchers and engineers into a new state-of-the-art robotics laboratory on U-M’s Ann Arbor campus. While the new robotics laboratory opens in 2020, by the end of this year Ford will move a dozen researchers into the North Campus Research Complex (NCRC), kicking off the first phase of expanded presence. The announcement is the latest in a series of actions by Ford as it moves toward having fully autonomous SAE-defined level 4-capable vehicles available for high-volume commercial use in 2021. Autonomous vehicles are part of Ford’s expansion to be an auto and a mobility company. Ford will lease the fourth floor of the new robotics laboratory. It is an approximately 140,000-square-foot building on Hayward Street, east of the university’s Space Research Building. The planned robotics laboratory will have space where machines walk, fly, drive and swim. The building will house labs, offices and classrooms, continuing a tradition of robotics leadership at U-M that includes the creation of MABEL, the world’s fastest-running robot with knees. By locating a team of more than 100 employees on campus, Ford benefits from being close to technical leaders as well as facilities, such as Mcity—the urban simulation test environment in Ann Arbor. Ford has been testing autonomous vehicles for more than 10 years, last fall becoming the first automaker to begin testing at Mcity. It also is tripling its fleet of autonomous research vehicles this year—making Ford’s fully autonomous vehicle fleet the largest of all automakers. Ford and U-M also announced that professors Matthew Johnson-Roberson and Ram Vasudevan will serve as leaders of a new autonomous vehicle research team comprising graduate students, postdoctoral fellows and researchers. Both professors, who began collaborating with Ford earlier this summer, bring a wealth of autonomous vehicle research experience. Dr. Johnson-Roberson is an assistant professor of Naval Architecture and Marine Engineering, and has worked in autonomous vehicles since the first DARPA Grand Challenge in 2004. His research focuses on robotic systems perception. Dr. Vasudevan is an assistant professor of Mechanical Engineering with a background in robotics and next-generation automotive technologies. U-M’s College of Engineering also named Professor Jessy Grizzle as Director of Robotics. Dr. Grizzle also serves as the key liaison between Ford’s autonomous vehicle research program and the College of Engineering. Grizzle’s familiarity with Ford will be of great value as the college and Ford strengthen their bonds. A U-M professor of engineering since 1987, Grizzle has spent nearly two decades as a Ford consultant working on programs such as environmentally friendly emissions, enhanced fuel economy and hybrid-electric vehicles. U-M is one of only a handful of universities to offer master’s and doctoral degrees in robotics, with the Ph.D. program now in its third year. More than 35 faculty members work in the field.

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