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North Decatur, GA, United States

Wang Z.,Research Bldg | Wang Z.,Emory University | Weitzmann M.N.,Research Bldg | Weitzmann M.N.,Emory University | And 6 more authors.
Journal of Biological Chemistry

Background: LPP induces synthesis of aggrecan and collagen II; however, the mechanism is unknown. Results: LPP up-regulated expression of aggrecan, collagen II, and SOX9 through binding to BMP-RII, initiating a complex Smad/BMP feedforward circuit. Conclusion: LPP could promote disc matrix production directly or boost the activity of exogenous BMPs. Significance: LPP may have value in the treatment of degenerated discs. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source

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