Wang Z.,Research Bldg |
Wang Z.,Emory University |
Weitzmann M.N.,Research Bldg |
Weitzmann M.N.,Emory University |
And 6 more authors.
Journal of Biological Chemistry
Background: LPP induces synthesis of aggrecan and collagen II; however, the mechanism is unknown. Results: LPP up-regulated expression of aggrecan, collagen II, and SOX9 through binding to BMP-RII, initiating a complex Smad/BMP feedforward circuit. Conclusion: LPP could promote disc matrix production directly or boost the activity of exogenous BMPs. Significance: LPP may have value in the treatment of degenerated discs. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc. Source