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Veselago V.G.,RAS A.M. Prokhorov General Physics Institute | Vinogradov E.A.,RAS A.M. Prokhorov General Physics Institute | Golovanov V.I.,RAS A.M. Prokhorov General Physics Institute | Zhukov A.A.,Joint Stock Company Russian Space Systems | And 4 more authors.
Technical Physics Letters | Year: 2011

We present the results of an experimental investigation of the characteristics of 8-12 GHz microwave radiation channeling in a layered medium based on a metamaterial (MM) with variable geometric characteristics, which was arranged in free space and excited iy a waveguide radiator. Data on the interaction between individual layers of the MM were obtained, which allowed us to elucidate the dependence of the electrodynamic characteristics of the MM on its geometric parameters. The principal possibility of controlling the position of the resonance peak of an MM with variable electrodynamic characteristics by changing its geometric parameters is demonstrated for the first time. © 2011 Pleiades Publishing, Ltd. Source

Kiyamova R.,NASU Institute of Molecular Biology and Genetics | Kostianets O.,NASU Institute of Molecular Biology and Genetics | Malyuchik S.,NASU Institute of Molecular Biology and Genetics | Filonenko V.,NASU Institute of Molecular Biology and Genetics | And 7 more authors.
Molecular Biotechnology | Year: 2010

Medullary breast carcinoma (MBC) is a relatively rare malignancy with heavy lymphocytic infiltration that despite cytologically anaplastic features and high mitotic index has more favorable prognosis than other types of breast cancer. Lymphocytic infiltration of tumors reflects ongoing immune response against tumor antigens which could represent a great interest as potential targets for cancer immunotherapy. The search for MBC antigens by SEREX methodology has not been successful due to a very high titer of false positive clones, representing immunoglobulin genes. Here, we describe a novel approach for generating cDNA expression libraries from MBC tumor samples which are depleted of IgG cDNA clones and, therefore, are suitable for the identification of novel tumorassociated antigens (TAA) by SEREX approach. Modified methodology allowed us to isolate a panel of known and novel TAA which are currently under further investigation. © Springer Science+Business Media, LLC 2010. Source

Kiknadze G.I.,Inventors Network GmbH | Gachechiladze I.A.,Inventors Network GmbH | Barnaveli T.T.,Research and Production Center
ASME 2013 Heat Transfer Summer Conf. Collocated with the ASME 2013 7th Int. Conf. on Energy Sustainability and the ASME 2013 11th Int. Conf. on Fuel Cell Science, Engineering and Technology, HT 2013 | Year: 2013

The concept design and fabrication of cost-effective and resource-saving Tornado Like Jet Condensers Heat Exchangers is described. Tornado Like Jet (TLJ) Technologies are utilizing the features of the streams of the continuous medium over the surfaces with dimples of double curvature inducing the secondary twisted vortexes self organization. (TLJ) Technologies are characterized by high functional efficiency of heat and mass exchange. The project is based on theoretical and experimental results obtained by the authors of the project in past years in development of a (TLJ) Technologies package. Copyright © 2013 by ASME. Source

Kasumov E.A.,Research and Production Center | Kasumov R.E.,Research and Production Center | Kasumova I.V.,Research and Production Center
Photosynthesis Research | Year: 2015

ATP is synthesized using ATP synthase by utilizing energy either from the oxidation of organic compounds, or from light, via redox reactions (oxidative- or photo phosphorylation), in energy-transforming membranes of mitochondria, chloroplasts, and bacteria. ATP synthase undergoes several changes during its functioning.The generally accepted model for ATP synthesis is the well-known rotatory model (see e.g., Junge et al., Nature 459:364-370, 2009; Junge and Müller, Science 333:704-705, 2011). Here, we present an alternative modified model for the coupling of electron and proton transfer to ATP synthesis, which was initially developed by Albert Lester Lehninger (1917-1986). Details of the molecular mechanism of ATP synthesis are described here that involves cyclic low-amplitude shrinkage and swelling of mitochondria. A comparison of the well-known current model and the mechano-chemiosmotic model is also presented. Based on structural, and other data, we suggest that ATP synthase is a Ca2+/H+-K+ Cl--pump-pore-enzyme complex, in which γ-subunit rotates 360° in steps of 30°, and 90° due to the binding of phosphate ions to positively charged amino acid residues in the N-terminal γ-subunit, while in the electric field. The coiled coil b2-subunits are suggested to act as ropes that are shortened by binding of phosphate ions to positively charged lysines or arginines; this process is suggested to pull the α3β3-hexamer to the membrane during the energization process. ATP is then synthesized during the reverse rotation of the γ-subunit by destabilizing the phosphated N-terminal γ-subunit and b2-subunits under the influence of Ca2+ ions, which are pumped over from storage - intermembrane space into the matrix, during swelling of intermembrane space. In the process of ATP synthesis, energy is first, predominantly, used in the delivery of phosphate ions and protons to the α3β3-hexamer against the energy barrier with the help of C-terminal alpha-helix of γ-subunit that acts as a lift; then, in the formation of phosphoryl group; and lastly, in the release of ATP molecules from the active center of the enzyme and the loading of ADP. We are aware that our model is not an accepted model for ATP synthesis, but it is presented here for further examination and test. © The Author(s) 2014. Source

Kiknadze G.I.,Research and Production Center | Gachechiladze I.A.,Research and Production Center | Barnaveli Jr. T.T.,Research and Production Center
ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) | Year: 2012

The mechanisms of the phenomenon of the tornado-like jets self-organization are described. Tornado-like jets are incorporated into a continuous medium stream and induced by three-dimensional reliefs of double curvature indented on surfaces. Copyright © 2012 by ASME. Source

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