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Demirkiran H.,Research and Development Laboratory
Advances in experimental medicine and biology

The remarkable need for bone tissue replacement in clinical situations, its limited availability and some major drawbacks of autologous (from the patient) and allogeneic (from a donor) bone grafts are driving researchers to search for alternative approaches for bone repair. In order to develop an appropriate bone substitute, one should understand bone structure and properties and its growth, which will guide researchers to select the optimal conditions for tissue culture and implantation. It's well accepted that bioceramics are excellent candidates as bone replacement with osteogenesis, osteoinduction and osteoconduction capacity. Therefore, the molecular and cellular interactions that take place at the surface of bioceramics and their relevance in osteogenesis excites many researchers to delve deeper into this line of research. Source

Salaga M.,Medical University of Lodz | Polepally P.R.,University of Mississippi | Sobczak M.,Medical University of Lodz | Grzywacz D.,Research and Development Laboratory | And 6 more authors.
Journal of Pharmacology and Experimental Therapeutics

The opioid and cannabinoid systems play a crucial role in multiple physiological processes in the central nervous system and in the periphery. Selective opioid as well as cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal (GI) motility and pain. In this study, we examined (in vitro and in vivo) whether PR-38 (2-O-cinnamoylsalvinorin B), a novel analog of salvinorin A, can interact with both systems and demonstrate therapeutic effects. We used mouse models of hypermotility, diarrhea, and abdominal pain. We also assessed the influence of PR-38 on the central nervous system by measurement of motoric parameters and exploratory behaviors in mice. Subsequently, we investigated the pharmacokinetics of PR-38 in mouse blood samples after intraperitoneal and oral administration. PR-38 significantly inhibited mouse colonic motility in vitro and in vivo. Administration of PR-38 significantly prolonged the whole GI transit time, and this effect was mediated by μ- and κ-opioid receptors and the CB1 receptor. PR-38 reversed hypermotility and reduced pain in mouse models mimicking functional GI disorders. These data expand our understanding of the interactions between opioid and cannabinoid systems and their functions in the GI tract. We also provide a novel framework for the development of future potential treatments of functional GI disorders. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics. Source

Munoz-Durango K.,University Paris - Sud | Munoz-Durango K.,University of Antioquia | Munoz-Durango K.,Research Center on Nutrition | Maciuk A.,University Paris - Sud | And 10 more authors.
Analytical Chemistry

Drug screening for antimalarials uses heme biocrystallization inhibition methods as an alternative to parasite cultures, but they involve complex processes and cannot detect artemisinin-like molecules. The described method detects heme-binding compounds by mass spectrometry, using dissociation of the drug-heme adducts to evaluate putative antiplasmodial activity. Applied to a chemical library, it showed a good hit-to-lead ratio and is an efficient early stage screening for complex mixtures like natural extracts. © 2012 American Chemical Society. Source

El Gouri M.,Universite Ibn Tofail | Cherkaoui O.,Research and Development Laboratory | Ziraoui R.,Universite Ibn Tofail | El Harfi A.,Universite Ibn Tofail
Journal of Materials and Environmental Science

In the present research, we have investigated the analysis of gases generated under thermal decomposition of neat and flame retarded DGEBA epoxy resin based on HGCP (Hexaglycidyl cyclotriphosphazene). The use of thermogravimetry coupled with Fourier transform infrared spectroscopy (TG-FTIR) has allowed the continuous detection of a number of the most important fire gases. The morphology of samples during thermal degradation have been observed by way of scanning electron microscopy (SEM) coupled with Energy Dispersive X-ray (EDX) analysis. We have shown that 5% add-on of HGCP can impart DGEBA UL94 V-0 rating. IR data and thermal decomposition data show that HGCP accelerates the emission of the inflammable gas and char forming of DGEBA. In addition, SEM pictures indicate that HGCP promotes foaming and char expansion, and improve gullys on char surface as well. All these fact were helpful to combine the gas action and the condensed phase action (intumescent) for HGCP flame retardancy. Source

Anithambigai P.,Universiti Sains Malaysia | Dinash K.,Universiti Sains Malaysia | Mutharasu D.,Universiti Sains Malaysia | Shanmugan S.,Universiti Sains Malaysia | Lim C.K.,Research and Development Laboratory
Thermochimica Acta

Thermal transient measurement based on structure function evaluation was used to measure the thermal resistance. The study signifies the importance of dual interface method in determining the exact point of separation between the board and the LED package. For a constant ambient temperature which was maintained at 28.2 ± 1.0 °C at 700 mA, the junction to board thermal resistance obtained was 10.84 K/W. In addition, an experimental set up has been reported in this work having a constant water flow beneath the external heat sink. More emphasis has been given in studying the effect of change of such measurement environment on the junction to board thermal resistance. It was revealed that the junction to board thermal resistance was not affected but the total real thermal resistance from junction to ambient was reduced significantly by 55.6% upon cooling with water. A study on the effect of light output on the total thermal resistance was performed and it was revealed that the efficiency and the reliability of an LED are strongly dependent on the optical properties of the device. © 2011 Elsevier B.V. All rights reserved. Source

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