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Hauzer W.,Research and Development Center Wroclaw | Czerski A.,Research and Development Center Wroclaw | Czerski A.,Wroclaw University of Environmental and Life Sciences | Zawadzki W.,Research and Development Center Wroclaw | And 9 more authors.
Journal of Physiology and Pharmacology | Year: 2014

The study was carried out on 10 swine of 20–30 kg body weight. Five animals were assigned to each of 2 groups. An aneurysm of the abdominal aorta was created experimentally in animals from the first and second study group. After 4 weeks, animals from the second group were subject to aneurysm repair using an aortic prosthesis. During the experiment, we measured the myoelectric activity of the muscular layer of the abdominal aorta and aneurysmal lesion with the ultrasonographic technique. Measurements of the aorta and aneurysmal lesion and histopathological analyses were carried out post-mortem. We found a statistically significant decrease in the myoelectric activity of the aorta on the aorta-straight prosthesis interface and a significant decrease in the thickness of the muscular layer of the aorta on the aorta-prosthesis interface. No similar changes were found for experimentally induced aneurysms of the abdominal aorta. Astraight prosthesis graft may not be the perfect option in the treatment of abdominal aortic aneurysm, as it contributes to the remodelling of the tissue on the prosthesis-aorta interface. This may result in the relapse of an aneurysm and post-operative complications. © 2014, Polish Physiological Society. All rights reserved. Source

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