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Radovic M.,Research and Development Center for Bioengineering Bioirc | Isailovic V.,Research and Development Center for Bioengineering Bioirc | Saveljic I.,Research and Development Center for Bioengineering Bioirc | Milosevic Z.,Research and Development Center for Bioengineering Bioirc | And 5 more authors.
2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015 | Year: 2015

Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for human coronary artery. In order to validate proposed model we used ten specific patients from CT study belonging to one of the following groups: (1) de-novo group - patients with new formed plaques, (2) old-lesions group - patients with plaques with progression and (3) control group - patients with plaques without progression. Plaque volume progression is fitted by using two time points for baseline and follow up. Results obtained within this study indicate high potential of this model to be used in clinical practice, thus assisting physicians by providing them valuable information about future disease progression. © 2015 IEEE.


Nikolic M.M.,University of Kragujevac | Isailovic V.M.,University of Kragujevac | Teal P.,Victoria University of Wellington | Radovic M.D.,Research and Development Center for Bioengineering Bioirc | Filipovic N.D.,University of Kragujevac
2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015 | Year: 2015

Cochlea is a part of the inner ear and it has complex anatomy and function. The proper functioning of the cochlea includes the generation of a traveling wave along the basilar membrane, which leads to depolarization of hair cells in the Organ of Corti and subsequent auditory nerve excitation (mechanoelectrical transduction). To represent the behavior of the organ of Corti, electro-mechanical cochlea model needs to be developed. This paper presents a simplified electro-mechanical state space model of the cochlea. © 2015 IEEE.

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