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CAMBRIDGE, MA, United States

Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: INFRA-2011-1.2.2. | Award Amount: 6.32M | Year: 2011

Marine life plays a vital role in the Earths ecosystem. Wise and judicious management of all relevant resources is of paramount importance to ensure that all forms of marine life remain sustainable. However, efforts in this direction are severely hindered by extreme compartmentalization and heterogeneity at all levels and sectors: the global, national, and local organizations active in the field; the different scientific disciplines involved; the methodologies used to acquire, format and present data; the procedures used to analyze the data; and several others. The main goal of the iMarine project is, thus, to launch an initiative aimed at establishing and operating an e-infrastructure supporting the principles of the Ecosystem Approach to fisheries management and conservation of marine living resources. iMarine has three main objectives: (i) the establishment of an iMarine Board, formed by representatives of international organisations involved in this domain, which will define a sustainability-driven data-centric e-infrastructure governance model and organizational and technological policy recommendations; (ii) the management and operation of this e-Infrastructure offering user-level and application-level services that support the recommended policies and provide relevant functionality to the stakeholders; (iii) the extension, adaptation and deployment of a rich set of software components that implement these services. Instrumental in the activities of iMarine will be the establishment of an active set of collaborations with other international initiatives. The aim will be to reuse and render interoperable existing policies, technologies, and e-infrastructures. By leveraging on these collaborations and by taking advantage of additional funding that these organizations invest in the project, the number of available resources brought into play will be maximized.


Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3.


Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3.


Copper ion treatments and methods of treatment are provided to treat various body conditions affecting the oral, respiratory and/or otic areas of the body. The copper ion treatments contain copper ions which bring about local and systemic therapeutic effects as a result of contacting anatomical tissue of the oral cavity, the nasal passages or ear canal. The copper ion treatments and methods involve copper ion-containing solutions, copper ion toothpaste and copper ion mouthwash. The copper ion-containing solutions can be delivered to the oral cavity by spraying or swabbing, can be delivered to the nostrils as spray, drops, or by swabbing, and can be delivered to the ear canal as spray, drops, or by swabbing. The copper ion toothpaste is used for brushing the teeth, and the copper ion mouthwash is used for rinsing the mouth.


Patent
Res Group, Inc. and Soma | Date: 2015-07-27

A crushed bacterial cells can be obtained by culturing a gram-negative bacterium and physically crushing a body of the gram-negative bacterium, comprises all components including immunostimulatory components in the bacterial cells, and comprises LPSs having molecular weights of 20,000 or less as active ingredients. The crushed bacterial cells is effective as a health food, drug, skin-care product, bath agent, feedstuff for protecting crustaceans, shellfish, fish, poultry, farm animals and pet animals from infections, and a feed additive for growth promotion, and can provide an innate immunostimulatory substance derived from a gram-negative bacterial cells having infection-preventing effects and growth promoting effects, an inexpensive and practical microbial crushed bacterial cells, and a composition thereof.

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