CAMBRIDGE, MA, United States
CAMBRIDGE, MA, United States
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Disclosed herein are methods of expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) peptide in a cell of a subject comprising: delivering into the cell of the subject an isolated nucleic acid expression construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3, wherein upon the delivering into the cell of the subject, the nucleic acid expression construct initiates expression of the GNE peptide or a therapeutically active fragment thereof. Also disclosed are methods of producing a GNE peptide in a cell comprising infecting the cell with an isolated nucleic acid construct that comprises a promoter operatively linked to a nucleic acid sequence encoding a GNE peptide or a therapeutically active fragment thereof, wherein the GNE peptide has the amino acid sequence of SEQ ID NO:3.


Provided is an apparatus and technique for monitoring the drying, cure, film formation, and viscoelastic properties of liquids solidifiable liquid films, and the insitu measurement of viscoelastic properties of solidified films.


The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.


Patent
Res Group, Inc. | Date: 2017-02-16

A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.


The present disclosure is generally related to systems, methods, and computer-readable storage devices for determining suitability of data presentation on a mobile device. An exemplary system is configured for receiving data descriptive of a communication to be distributed to a plurality of mobile devices; analyzing the data to identify one or more attributes of the communication; and generating a score for the communication based on the one or more attributes of the communication, wherein the score is representative of a suitability of the communication for presentation at a mobile device.


Patent
The Government Of The United States and Res Group, Inc. | Date: 2016-08-12

A method for the prevention or treatment of human immunodeficiency virus infection by administering an effective amount of amifostine, phosphonol, or similar compound to an individual in need is provided.


System and method for optimizing composition of a pool from which members are selected to serve on market research panels are described. In one embodiment, the system includes a database comprising a plurality of member profiles and survey data associated with the members and a datamart for periodically scanning the database to discover events and subsequently logging each of the discovered events in an event log. The system further includes an offense module for periodically evaluating the event log to determine whether one of the discovered events comprises an offense committed by one of the members and logging the offense in an offense log and an audit module for performing an audit of the one of the members and logging results of the audit in an audit log.


Patent
Res Group, Inc. | Date: 2016-09-14

Provided herein are topical formulations containing copper ions and methods of treating inflammatory, microbial, and arthritic conditions in various areas of the body using such formulations. Methods of treating osteoarthritis using topical copper ion treatments are provided. Methods of treating and preventing microbial infections using copper ion treatments are further provided, including methods of preventing biofilm. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.


A method of matching a first entity to a second entity by evaluating Boolean expressions includes identifying a set of criteria vertices for a second entity vertex by traversing a graph database in a manner constrained to fact vertices identified for the second entity. The graph database relates fact vertices to the criteria vertices by edges corresponding to Boolean expressions for satisfying criteria for matching first entities to second entities. The method additionally includes selecting one of the first entities based on the criteria vertices of the set. The method further includes matching the first entity to the second entity based on the selection.


This disclosure is directed to artificially intelligent (AI) communication generation by traversing routes of a graph in a complex computing network. The intelligent communication generation is used for determining whether an input signal has certain desired signal attributes.

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