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Nygren K.G.,IVF Unit | Sullivan E.,University of New South Wales | Zegers-Hochschild F.,Unit of Reproductive Medicine | Mansour R.,Egyptian Center | And 3 more authors.
Fertility and Sterility | Year: 2011

Objective: To analyze information on assisted reproductive technologies (ART) performed globally. Design: Data on access, efficacy, and safety of ART were collected for the year 2003 from 54 countries. Setting: National and regional ART registries globally. Patient(s): Patients undergoing ART globally. Intervention(s): Collection and analysis of international ART registry data. Main Outcome Measure(s): Number of cycles performed in reporting countries and regions globally for different ART procedures with resulting pregnancy, live birth and multiple birth rates. Result(s): A total of 433,427 initiated cycles reported in this registry resulted in 173,424 babies born. This corresponded to a delivery rate per aspiration of 22.4% for in vitro fertilization (IVF), 23.3% for intracytoplasmic sperm injection (ICSI), and a delivery rate per transfer of 17.1% for frozen embryo transfer. Although there is wide variation among countries and regions, the overall proportion of deliveries with twins and triplets from IVF and ICSI was 24.8% and 2.0%, respectively. There were wide variations in access, and compared with the previous report (year 2002), there was a 3.9% increase in the number of reported cycles and a minor increase in the delivery rate per aspiration. There was also a marginal decline in the mean number of embryos transfered and in the rate of multiple births. Conclusion(s): ART access, efficacy, and safety varies greatly globally. Collection and analysis of data over time will benefit ART patients, providers, and policy makers. © 2011 by American Society for Reproductive Medicine. Source


Palomba S.,Unit of Reproductive Medicine
Journal of Clinical Endocrinology and Metabolism | Year: 2015

Normogonadotropic anovulation, including polycystic ovary syndrome (PCOS), is one of the main causes of infertility. Recent meta-analysis and randomized controlled trial suggest the use of aromatase inhibitors (ie, letrozole) as effective drug and first-line treatment to restore fertility in these patients. The current manuscript will give a critical, provocative, and personal point of view on the topic. Copyright © 2015 by the Endocrine Society. Source


Zegers-Hochschild F.,Unit of Reproductive Medicine
Fertility and Sterility | Year: 2011

Societies in Latin America are not scientifically driven and therefore, the allocation of human and economic resources to research is meager, as a reflection of this as well as other cultural and economic realities. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc. Source


MacKenna A.,Unit of Reproductive Medicine | Crosby J.,Unit of Reproductive Medicine | Zegers-Hochschild F.,Unit of Reproductive Medicine | Zegers-Hochschild F.,Diego Portales University
Reproductive BioMedicine Online | Year: 2013

This study assessed the development of sibling embryos to blastocyst as a prognostic factor for patients undergoing embryo transfer at day 3. A retrospective analysis of a clinical and embryology database including 353 patients who underwent 393 cycles of intracytoplasmic sperm injection with day-3 embryo transfer and excess embryos, maintained in culture until day 5, was performed. Cycles were divided into group A and group B (with and without blastocyst formation, respectively). Age and basal FSH were similar in both groups. Statistically significant differences in clinical pregnancy rates (55.8% versus 40.6%; P = 0.0031), live birth rates (50.0% versus 37.2%; P = 0.012) and implantation rates (34.2% versus 23.7%; P = 0.0035) were observed in groups A and B, respectively. Odds ratios showed women from group A had 1.85- and 1.68-times the odds of patients from group B of achieving clinical pregnancy and a live birth, respectively. Cumulative live birth rate for group A, after one cycle of vitrified-warmed blastocyst transfer, was 66.4%. The development of sibling embryos to blastocyst is a prognostic factor for the outcome of the cycle in which transfer is performed at day 3 and provides valuable information about the prognosis of subsequent cycles. © 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Source


Schwarze J.-E.,Unit of Reproductive Medicine | Crosby J.A.,Unit of Reproductive Medicina Unit | Zegers-Hochschild F.,Unit of Reproductive Medicina Unit | Zegers-Hochschild F.,Diego Portales University
Reproductive BioMedicine Online | Year: 2015

Abstract Embryo cryopreservation is an integral part of assisted reproduction techniques; it allows the sequential transfer of all embryos, thus diminishing the risk of multiple pregnancies and associated perinatal complications. To address concerns about the safety of this procedure, neonatal outcome after 43,070 fresh embryo transfers was compared with 12,068 frozen-thawed embryo transfers (FET). After adjusting for maternal age, gestational age, embryo development at time of transfer, number of babies born and gestational order, FET was not found to be associated with an increase in perinatal mortality (odds ratio [OR] 1.72, 95% confidence interval [CI] 0.81 to 3.62); preterm birth (OR 1.05, 95% CI 0.93 to 1.18); or extreme preterm birth (OR 0.82, 95% CI 0.64 to 1.06). Furthermore, after correcting for known confounding factors, FET was found to be associated with an increase in neonatal weight of 39.7 g (95% CI 1.54 to 64.10; P < 0.0001). Embryo cryopreservation was, therefore, not associated with an increase in the risk of poor perinatal outcome. © 2015 Reproductive Healthcare Ltd. Source

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