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Briganti F.,Unit of Interventional Neuroradiology | Leone G.,Unit of Interventional Neuroradiology | Briganti G.,Unit of Interventional Neuroradiology | Orefice G.,Reproductive and Odontostomatologic science | And 2 more authors.
Neuroradiology Journal | Year: 2013

We describe a 62-year-old woman who presented with a history of ataxia, dizziness and urinary urgency. Neurological examination disclosed a positive Romberg sign, ataxia and postural instability. A magnetic resonance imaging (MRI) scan showed Chiari type 1 malformation (CM1). Forty-eight months later, the patient was clinically improved and underwent a second MRI examination, which showed complete resolution of the Chiari 1 malformation. Spontaneous resolution of CMl is exceptionally rare and has to be considered in the radiological and clinical management.

Piazza O.,University of Salerno | Micciche V.,University of Salerno | Esposito C.,Liver Transplant Unit | Romano G.,Reproductive and Odontostomatologic science | De Robertis E.,Reproductive and Odontostomatologic science
Trends in Anaesthesia and Critical Care | Year: 2016

Risk evaluation for the development of postoperative complications is essential to select the patients that are able to face major abdominal surgery, to strengthen the process of informed consent and to optimize perioperative diagnostic strategies in patients at higher risk. The estimation of functional reserve is particularly important, since a poor cardiopulmonary reserve determines the inability to cope with the stress induced by surgery and thus contributes to the development of postoperative complications. Cardiopulmonary exercise testing (CPET) derived variables are helpful for patients' stratification; 6 min walk test (6MWT) could also be of use, by itself or in association with other risk predictors (clinical scores and biomarkers). A hierarchy of tests may be used to describe risk: simple clinical risk scores may be used to screen out low risk patients, whereas patients at high or uncertain risk could be evaluated by a more complex battery of tests including CPET and biomarkers. © 2016 Elsevier Ltd.

Pignataro G.,Reproductive and Odontostomatologic science | Ziaco B.,CNR Institute of Biostructure and Bioimaging | Tortiglione A.,Reproductive and Odontostomatologic science | Gala R.,Reproductive and Odontostomatologic science | And 10 more authors.
ACS Chemical Neuroscience | Year: 2015

We investigated the effect of the VEGF-mimetic peptide, QK, on ischemic brain damage and on blood-brain barrier permeability in the rat. QK administered by the intracerebroventricular, intravenous, or intranasal route caused a 40% decrease in ischemic brain damage induced by permanent occlusion of the middle cerebral artery relative to that in controls. No increase in the volume of the ischemic hemisphere compared to that of the contralateral nonischemic hemisphere was observed in rats treated with QK, suggesting that this peptide did not cause brain edema. The effect of QK on vessel permeability was evaluated by intravital pial microvessel videoimaging, a technique that allows the pial vessels to be visualized through a surgically prepared open cranial window. The results showed that QK did not cause any leakage of intravenously injected fluorescein-dextran conjugates after intracarotid administration or topical application to the brain cortex. Collectively, these data suggest that QK may exert neuroprotective activity in the context of stroke without promoting any increase in vascular permeability. Because VEGF's neuroprotective activity may be overshadowed by the appearance of brain edema and microbleeds, QK could represent a significant step forward in stroke treatment. © 2015 American Chemical Society.

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