Cantone E.,Reproductive and Odontostomatologic Science |
Cantone E.,University of Naples Federico II |
Maione N.,Reproductive and Odontostomatologic Science |
Di Rubbo V.,Reproductive and Odontostomatologic Science |
And 2 more authors.
Laryngoscope | Year: 2015
Objective To evaluate the effectiveness of crenotherapy on the olfactory performance of elderly patients with chronic rhinosinusitis (CRS). Study Design A longitudinal case-control study of a cohort of elderly patients affected by CRS and olfactory dysfunction assessed with the Sniffin' Sticks (Burghart Medical Technology, Wedel, Germany) (SS) olfactory test. Methods One hundred and thirty-seven elderly subjects with CRS were divided into two groups. The investigational arm (n = 69) underwent crenotherapy with hyperthermal water, rich in mineral salts, and the control group (n = 68) underwent NaCl 0.9% both for 12 days. At baseline and at 1 and 6 months after treatment, both groups underwent ear nose and throat assessment and SS. Self-report questionnaires were administered at baseline to evaluate the patients' own olfactory response, and after treatment to evaluate their degree tolerability. Olfactory performance was then evaluated in elderly subjects with hyposmia without CRS (n = 40) and in younger subjects with both hyposmia and CRS (n = 40). Results No adverse reactions were reported after crenotherapy. The SS total score showed that crenotherapy induced a statistically significant improvement in the olfactory function of both the elderly and the younger subjects with hyposmia and CRS. By contrast, no improvement was observed in the control arm and in the elderly with hyposmia without CRS. All subjects showed a good degree of tolerability. Conclusions We demonstrated that crenotherapy effectively improves olfactory function in elderly patients with CRS. Finally, our study suggests that crenotherapy represents a safe therapeutic strategy for the treatment of CRS and olfactory dysfunction in the elderly. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.
Piazza O.,University of Salerno |
Micciche V.,University of Salerno |
Esposito C.,Cardarelli Hospital |
Romano G.,Reproductive and Odontostomatologic science |
De Robertis E.,Reproductive and Odontostomatologic science
Trends in Anaesthesia and Critical Care | Year: 2016
Risk evaluation for the development of postoperative complications is essential to select the patients that are able to face major abdominal surgery, to strengthen the process of informed consent and to optimize perioperative diagnostic strategies in patients at higher risk. The estimation of functional reserve is particularly important, since a poor cardiopulmonary reserve determines the inability to cope with the stress induced by surgery and thus contributes to the development of postoperative complications. Cardiopulmonary exercise testing (CPET) derived variables are helpful for patients' stratification; 6 min walk test (6MWT) could also be of use, by itself or in association with other risk predictors (clinical scores and biomarkers). A hierarchy of tests may be used to describe risk: simple clinical risk scores may be used to screen out low risk patients, whereas patients at high or uncertain risk could be evaluated by a more complex battery of tests including CPET and biomarkers. © 2016 Elsevier Ltd.
Pignataro G.,Reproductive and Odontostomatologic science |
Ziaco B.,CNR Institute of Biostructure and Bioimaging |
Tortiglione A.,Reproductive and Odontostomatologic science |
Gala R.,Reproductive and Odontostomatologic science |
And 10 more authors.
ACS Chemical Neuroscience | Year: 2015
We investigated the effect of the VEGF-mimetic peptide, QK, on ischemic brain damage and on blood-brain barrier permeability in the rat. QK administered by the intracerebroventricular, intravenous, or intranasal route caused a 40% decrease in ischemic brain damage induced by permanent occlusion of the middle cerebral artery relative to that in controls. No increase in the volume of the ischemic hemisphere compared to that of the contralateral nonischemic hemisphere was observed in rats treated with QK, suggesting that this peptide did not cause brain edema. The effect of QK on vessel permeability was evaluated by intravital pial microvessel videoimaging, a technique that allows the pial vessels to be visualized through a surgically prepared open cranial window. The results showed that QK did not cause any leakage of intravenously injected fluorescein-dextran conjugates after intracarotid administration or topical application to the brain cortex. Collectively, these data suggest that QK may exert neuroprotective activity in the context of stroke without promoting any increase in vascular permeability. Because VEGF's neuroprotective activity may be overshadowed by the appearance of brain edema and microbleeds, QK could represent a significant step forward in stroke treatment. © 2015 American Chemical Society.
Briganti F.,Unit of Interventional Neuroradiology |
Leone G.,Unit of Interventional Neuroradiology |
Briganti G.,Unit of Interventional Neuroradiology |
Orefice G.,Reproductive and Odontostomatologic science |
And 2 more authors.
Neuroradiology Journal | Year: 2013
We describe a 62-year-old woman who presented with a history of ataxia, dizziness and urinary urgency. Neurological examination disclosed a positive Romberg sign, ataxia and postural instability. A magnetic resonance imaging (MRI) scan showed Chiari type 1 malformation (CM1). Forty-eight months later, the patient was clinically improved and underwent a second MRI examination, which showed complete resolution of the Chiari 1 malformation. Spontaneous resolution of CMl is exceptionally rare and has to be considered in the radiological and clinical management.