Zhang Q.,Renmins Hospital |
Du X.,Xiangya Hospital |
Xu Y.,Renmins Hospital |
Dang L.,Renmins Hospital |
And 2 more authors.
Experimental and Therapeutic Medicine | Year: 2013
The present study examined the effects of Gouqi (Lycium barbarum) on the learning and memory abilities of an APP/PS1 double transgenic mouse model of Alzheimer's disease. We employed a Morris water maze to examine the spatial memory in this mice line with or without Gouqi extracts treatment. We identified that 2 weeks of oral administration of Gouqi extracts at 10 mg/kg improved the performance of the APP/PS1 mice in the learning and the memory retrieval phases of the Morris maze. In correlation with this, the levels of Aβ(1-42) in hippocampal tissue were reduced by the Gouqi treatment. We conclude that pharmacological treatment with Gouqi extracts is beneficial at the later stages of Alzheimer's disease.
PubMed | Renmins Hospital
Type: Journal Article | Journal: Experimental and therapeutic medicine | Year: 2013
The present study examined the effects of Gouqi (