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Shanghai, China

Findlay J.Y.,Mayo Medical School | Wen D.,Renji Hospital | Mandell M.S.,University of Colorado at Denver
Current Opinion in Organ Transplantation | Year: 2010

PURPOSE OF REVIEW: Cardiovascular disease has emerged as a leading cause of perioperative morbidity and mortality in renal and liver transplant patients. There is no consensus on how to diagnose cardiac disease in transplant patients. Further, there is significant disagreement in the literature regarding the use of routine screening methods to detect disease. This review will explore published observations on cardiac complications in renal and liver transplant patients to try and determine why investigators hold such divergent opinions. RECENT FINDINGS: The prevalence of cardiac disease is greater in renal and liver transplant patients than in the general public. Complications of cardiac disease play a large role in early mortality and graft loss in the postoperative period. While the presence of risk factors seems to predict coronary disease in renal disease, these factors do not perform as well in liver disease. Noninvasive stress testing for coronary artery disease seems to have low sensitivity in both transplant populations. However, the measurement of cardiac troponin seems to be of some value in predicting early mortality. SUMMARY: Physicians have not identified an effective yet cost-effective way to screen transplant patients for cardiac disease. Therefore, the first step in creating widely accepted protocols demand that physicians decide what predictive power that screening tests should have in this unique population © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.. Source


Chen X.B.,Renji Hospital | Li R.X.,Yunnan Jiuzhou Hospital | Yang H.N.,Yunnan Jiuzhou Hospital | Dai J.C.,Renji Hospital
International Journal of Impotence Research | Year: 2014

This study aimed to establish a reference range of penile length and circumference of adult males in China, and to compare the penile dimensions of different ethnical backgrounds. To do this, penile length and circumference measurements were obtained from 5196 healthy males attending the Urology Counseling Clinic. The mean value of penile dimensions was a flaccid length of 6.5±0.7 cm, a stretched length of 12.9±1.2 cm and a flaccid circumference of 8.0 ±0.8 cm. In the subgroup of 311 males, the mean erectile length was 12.9±1.3 cm and the mean erectile circumference was 10.5±0.9 cm, the mean flaccid and erectile glans lengths were 2.7±0.3 and 3.4±0.4 cm, respectively, and the mean flaccid and erectile glans diameters were 2.6±0.2 and 3.4±0.4 cm, respectively. We found that flaccid penile length and circumference varied among different ethnicities. This study established a reference range for penile dimensions, which will help when counseling patients worried about their penile size or seeking penis enlargement surgery. We also found that penile dimensions are different in different ethnicities, but further investigations are needed to validate this. © 2014 Macmillan Publishers Limited All rights reserved. Source


Hou K.-L.,Renji Hospital | Hao M.-G.,Shanghai JiaoTong University | Bo J.-J.,Renji Hospital | Wang J.-H.,Shanghai JiaoTong University
Chinese Journal of Cancer | Year: 2010

Chemokines, a family of small cytokines, were initially characterized as proinflammatory chemoattractant cytokines that regulated cell trafficking and adhesion. Today, attention focuses on chemokines because evidence shows that they play a critical role in tumor initiation, promotion, and progression. CXCR7, a seven-transmembrane G-protein-coupled CXC chemokine receptor, has recently been identified as binding with high affinity to chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1). In this review, we highlight the current knowledge about the role of CXCR7 in the biologic processes of cancer, including cancer growth, survival, adhesion, invasion, metastasis, angiogenesis, and progression. The use of peptides, small molecules, antibodies, or small interfering RNA to target CXCR7 shows promise as new potential avenues for the treatment of cancer. Source


Xue H.,Shanghai JiaoTong University | Liu J.,Shanghai JiaoTong University | Lin B.,Fudan University | Wang Z.,Renji Hospital | And 2 more authors.
PLoS ONE | Year: 2012

Background: Potential functional allele A/T single nucleotide polymorphism (SNP) of Interleukin 8 (IL-8) promoter -251has been implicated in gastric cancer risk. Methods: We aimed to explore the role of A/T SNP of IL-8 -251 in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. Eighteen studies were ultimately eligible for the meta-analysis of IL-8 - 251 A/T SNP. We adopted the most probably appropriate genetic model (codominant model). Potential sources of heterogeneity were sought out via stratification and sensitivity analyses, and publication biases were estimated. Results: Between IL-8 -251 AA genotype with gastric cancer risk, statistically significant association could be noted with overall gastric cancer, evidently noted in Asians, witnessed in high quality subgroup, and apparently noted in intestinal-type gastric cancer. Conclusions: Our meta-analysis indicates that IL-8 -251 AA genotype is associated with the overall risk of developing gastric cancer and may seem to be more susceptible to overall gastric cancer in Asian populations. IL-8 -251 AA genotype is more associated with the intestinal-type gastric cancer. IL-8 -251 AA genotype is not associated with Helicobacter Pylori infection status in our meta-analysis. Impact: The analyses suggest that IL-8 -251 AA genotype may be an important biomarker of gastric cancer susceptibility for Asians, especially for Chinese Han population, the assumption that needs to be further confirmed in future well-designed studies in China. © 2012 Xue et al. Source


Bai Y.,Renji Hospital | Ye M.,Shanghai JiaoTong University | Cao H.,Renji Hospital | Ma X.,Renji Hospital | And 2 more authors.
Breast Cancer Research and Treatment | Year: 2012

The primary objective was to assess the costeffectiveness, from the Chinese societal perspective, of additional radiotherapy for women with early breast cancer after breast-conserving surgery (BCS). The Markov model was constructed to simulate women's transitions across various health states based on the clinical course of breast cancer (no recurrence, local or distant recurrence, and death) and treatment strategy (radiotherapy vs. no-radiotherapy). The clinical and utility data were estimated from published studies. Costs were estimated from the perspective of Chinese society. Quality-adjusted life-years (QALYs) and incremental cost-effective ratios (ICERs) were determined. Probabilistic and one-way sensitivity analyses were performed. The addition of radiotherapy following BCS was associated with improved overall survival (22.20 vs. 19.51 years) and QALYs (13.25 vs. 11.75) and reduced lifetime costs ($24,518.9 vs. 25, 147.0). The ICER of radiotherapy vs. no-radiotherapy was -420.56/QALY gained. Sensitivity, subgroup and scenario analyses indicated that these results were robust against plausible assumptions and variations. In health resource-limited settings, the addition of radiotherapy is a very cost-effective strategy in comparison to no-radiotherapy in women with early breast cancer. © Springer Science+Business Media New York 2012. Source

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