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Patent
Renishaw and Metrology Software Products Ltd | Date: 2017-07-19

A calibration device (30) for a machine tool is described that includes a base (36) attachable to a machine tool and a calibration artefact (32), such as a sphere of known radius. A deflection mechanism attaches the calibration artefact to the base and allows movement of the calibration artefact (32) relative to the base (36) when an external force is applied to the calibration artefact (32). The deflection mechanism also maintains the calibration artefact (32) in a defined rest position relative to the base (36) in the absence of an applied external force. A sensor (46) is provided for sensing the extent of movement of the calibration artefact (32) relative to the base (36). A method of using the device (30) with a reference tool to accurately determine a position of a calibration artefact (32) is also described.


Patent
Renishaw | Date: 2017-02-08

A method of measuring a slot using a contact probe having a stylus tip mounted on a positioning apparatus, comprising positioning the stylus tip such that it is in contact with the edges that define the mouth of the slot.


Patent
Renishaw | Date: 2017-04-12

A frequency tuneable laser device comprises a cavity mode selector (10) and a cavity tuning arrangement(22, 24). The cavity mode selector (10) has a frequency response with a selection feature that is alignable in frequency with a selected cavity mode of the laser device. The cavity tuning arrangement (22, 24) comprises a plurality of reflective elements arranged in optical series, and is used to adjust the effective optical path length of the laser cavity to move the cavity modes in frequency. The laser device further comprises means (30, 40) for making the cavity mode selector (10) and the cavity tuning arrangement (22, 24) perform a simultaneous coordinated movement such that respective frequencies of the selection feature and the selected cavity mode vary with substantially the same dependence on a parameter characterising the simultaneous coordinated movement. For example, a periscope (22, 24) with a co- rotating etalon (10) can be used to provide mode hop free tuning of the laser device, particularly where the periscope (22, 24) is configured to give a predominantly cosine tuning response.


Patent
Renishaw | Date: 2017-01-04

A method of inspecting a hole in an object with at least one camera probe mounted on a coordinate positioning machine. The method comprises: for a plurality of different viewpoints obtaining at least one image of a silhouette of the hole from a first end of the hole, so as to obtain a set of silhouette images of the hole, the hole being backlit so as to form said silhouette, and using said set of silhouette images of the hole to infer at least part of the boundary of the hole at a given height.


Patent
Renishaw | Date: 2017-03-01

A machine tool is provided with a toolsetting probe(14)mounted on a bed or table (10), and a workpiece-sensing probe (16) which can be mounted in a movable spindle(12). Both probes are calibrated by using them to make measurements against each other. The arbitrary length of the workpiece-sensing probe (16) is used to calibrate the toolsetting probe, rather than using a pre-calibrated artefact of known length mounted in the spindle. A stylus disc (26) of the toolsetting probe (14) has a pre-calibrated size or dimension, and the workpiece-sensing probe is calibrated with respect to that. This obviates the need for skilful manual calibration procedures using pre-calibrated artefacts and manual measurement tools.


An additive manufacturing apparatus comprising a build chamber (101) in which an object is built and a flow device (1a, 1b). The flow device (1a, 1b) comprises a body (2) having a Coand surface (11, 12) and a passageway (10) connectable to a pressurised gas source. The passageway (10) has an opening (5, 6) located adjacent to the Coand surface (11, 12) to, in use, direct a jet of gas over the Coand surface (11, 12). A space adjacent the Coand surface is in fluid communication with the build chamber (101) such that gas drawn into and/or propelled from the space causes gas flow through the build chamber (101).


Patent
Renishaw | Date: 2017-01-25

Neurosurgical apparatus is described that comprises a guidance device (40; 100; 150; 200; 250) comprising a guide tube (42; 104; 152; 202) and a neurosurgical instrument (60; 110) for insertion into the guide tube (42; 104; 152; 202). The inner surface (46; 108) of the guide tube (42; 104; 152; 202) is arranged, for example profiled,to at least partially engage the outer surface (72; 120) of the neurosurgical instrument (60; 110) when inserted therein. The guide tube (42; 104; 152; 202) thus guides the neurosurgical instrument (60; 110) along a predefined path through the guide tube (42; 104; 152; 202). At least one of the guidance device (40; 100; 150; 200; 250) and the outer surface of the neurosurgical instrument (60; 110) are configured to provide a fluid return path (50a-50c; 122a-122c) for carrying any fluid displaced from within the guide tube (42;104; 152; 202) during insertion of the neurosurgical instrument (60; 110) into the guide tube (42; 104; 152; 202). A seal may also be provided for sealing the fluid return path (50a-50c; 122a-122c).


A method and apparatus for controlling or programming a measurement path for a probe mounted on a coordinate positioning apparatus (e.g. an articulating probe head mounted on a CMM) which enables both the position of the probe tip and the orientation of the probe to be varied. In a first mode, the position of the probe tip is adjusted. In a second mode the orientation of the probe is adjusted, whilst keeping the location of the probe tip unchanged. This may be achieved either online on the coordinate positioning apparatus or offline in software.


Patent
Renishaw | Date: 2017-09-27

This invention concerns an additive manufacturing apparatus for building a part by selectively consolidating flowable material in a layer-by-layer process comprising a build chamber (101) for building the part, a module (105, 106) for providing a focussed energy beam for consolidating flowable material in the build chamber, a gas flow circuit for generating a gas flow through the build chamber (101). At least one filter assembly (200, 201) may be arranged in the gas flow circuit, the or each filter assembly (200, 201) having associated therewith a valve (V-4, V-8)operable to seal the gas circuit upstream from the filter assembly (200, 201) and a valve (V- 5, V-9) operable to seal the gas flow circuit downstream of the filter assembly (200, 201),the arrangement allowing a filter element(E-5, E-7 )of the filter assembly (200, 201) to be changed whilst maintaining a controlled atmosphere in the build chamber (101). The apparatus may further comprise a purging device (210) configured to purge air from the or each filter assembly (200, 201) when the valves (V-4, V-5; V-8, V-9)associated with that filter assembly (200, 201) have sealed the filter assembly (200, 201) from the gas flow. Alternatively or additionally, a controller (131) may be arranged to control the valves (V-4, V-5; V-8, V-9) associated with the or each filter assembly (200, 201) such that the filter assemblies (200, 201)are closed off to gas flow from the build chamber (101) during a period in which the inert gas atmosphere in the build chamber(101)is compromised as a result of opening the door to the build chamber(101).The apparatus may comprise a pair of filter assemblies (200, 201) arranged in parallel within the gas flow circuit, the arrangement allowing a filter element (E-5, E-7) of the each filter assembly (200, 201) to be changed during a build by allowing the filter element (E-5, E-7) of one filter assembly (200, 201) to be changed whilst the filter element (E-5, E-7 )of the other filter assembly (200, 201) is connected to filter particulates from the gas flow. A monitoring device (I-3, I-5) may be provided for detecting a property associated with the gas flow and a controller (131) arranged to control the valves to switch the filter assembly (200, 201) connected in line with the gas flow based upon signals from the monitoring device(I-3, I-5).


The main focus of TreatER is conducting a randomized, placebo-controlled, first-in-human, proof-of-concept, safety and efficacy study of intracerebrally administered CDNF protein therapy in patients with Parkinsons disease (PD), using a neurosurgically implanted Drug Delivery System (DDS), which will also be clinically validated in the study. Thus the TreatER project has two independent goals, either of which alone can have significant impact addressing unmet clinical needs in chronic diseases, and advancing innovative European technologies: 1) Proof-of-concept of CDNF protein therapy for disease modification in PD. The patented European innovation CDNF has further potential in other ER stress related indications. 2) Clinical validation of DDS, an already clinically tested approach for accurately targeted intracerebral infusions in PD. The patented European innovation DDS has also significant potential in other indications needing intracerebral infusions. The clinical study builds on extensive preclinical research and related data on CDNF, including completed acute and chronic toxicology studies in non-human primates supporting an excellent safety profile. Further, the clinical study builds on existing clinical experience on DDS and related neurosurgery. Both conventional and novel means for assessing the efficacy of the treatment will be utilized. This requires strong interdisciplinary expertise and knowledge available in the consortium, including: Regulatory expertise in drug and medical device development; neurological and neurosurgical expertise in PD; PET imaging expertise specific to PD; Scientific expertise in novel neurotrophic factors, in specific CDNF; and GMP manufacturing expertise of novel biological drug compounds. Clinical trial applications are currently being submitted in Finland and Sweden, in accordance with previously obtained scientific advice from regulatory authorities in those countries as well as from MHRA (UK) and EMAs ITF.

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