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Selimis A.,IESL FORTH | Mironov V.,Renato Archer Information Technology Center | Farsari M.,IESL FORTH
Microelectronic Engineering | Year: 2014

For a great variety of research fields extending from photonics to tissue engineering applications, the requests for the construction of three-dimensional structures with high resolution grow more and more imperative. Towards this aim, the direct laser writing technique by multi-photon polymerization, due to its unique properties and characteristics, has proven to be an indispensable tool to high accuracy structuring and has been put on the map as an emerging technology for scaffold 3D printing. In the present review, the basic principles of multi-photon polymerization are presented, the experimental set-up requirements are described and the employed materials demands are thoroughly mentioned as well as the most representative examples of the recent developments in the field. © 2014 Elsevier B.V. All rights reserved. Source


Mehesz A.N.,Medical University of South Carolina | Brown J.,Clemson University | Hajdu Z.,Medical University of South Carolina | Beaver W.,York College | And 4 more authors.
Biofabrication | Year: 2011

Development of methods for scalable biofabrication of uniformly sized tissue spheroids is essential for tissue spheroid-based bioprinting of large size tissue and organ constructs. The most recent scalable technique for tissue spheroid fabrication employs a micromolded recessed template prepared in a non-adhesive hydrogel, wherein the cells loaded into the template self-assemble into tissue spheroids due to gravitational force. In this study, we present an improved version of this technique. A new mold was designed to enable generation of 61 microrecessions in each well of a 96-well plate. The microrecessions were seeded with cells using an EpMotion 5070 automated pipetting machine. After 48 h of incubation, tissue spheroids formed at the bottom of each microrecession. To assess the quality of constructs generated using this technology, 600 tissue spheroids made by this method were compared with 600 spheroids generated by the conventional hanging drop method. These analyses showed that tissue spheroids fabricated by the micromolded method are more uniform in diameter. Thus, use of micromolded recessions in a non-adhesive hydrogel, combined with automated cell seeding, is a reliable method for scalable robotic fabrication of uniform-sized tissue spheroids. © 2011 IOP Publishing Ltd. Source


Machado R.C.,Renato Archer Information Technology Center | Rittner L.,University of Campinas | Lotufo R.A.,University of Campinas
Procedia Computer Science | Year: 2011

Adessowiki is a collaborative platform for scientific programming and document writing. It is a wiki environment that carries simultaneously documentation, programming code and results of its execution without any software configuration such as compilers, libraries and special tools at the client side. This combination of a collaborative wiki environment, central server and execution of code at rendering time enables the use of Adessowiki as an executable paper platform, since it fulfills the need to disseminate, validate, and archive research data. © 2011 Published by Elsevier Ltd. Source


Thomas G.L.,Federal University of Rio Grande do Sul | Mironov V.,Renato Archer Information Technology Center | Nagy-Mehez A.,Medical University of South Carolina | Mombach J.C.M.,Federal University of Santa Maria
Physica A: Statistical Mechanics and its Applications | Year: 2014

Fusion of cell tissues is an ubiquitous phenomenon and has important technological applications including tissue biofabrication. In this work we present experimental results of aggregates fusion using adipose derived stem cells (ADSC) and a three dimensional computer simulation of the process using the cellular Potts model with aggregates reaching 10,000 cells. We consider fusion of round aggregates and monitor the dimensionless neck area of contact between the two aggregates to characterize the process, as done for the coalescence of liquid droplets and polymers. Both experiments and simulations show that the evolution of this quantity obeys a power law in time. We also study quantitatively individual cell motion with the simulation and it corresponds to an anomalous diffusion. © 2013 Elsevier B.V. All rights reserved. Source


Silva J.V.L.,Renato Archer Information Technology Center | Rezende R.A.,Renato Archer Information Technology Center
IFAC Proceedings Volumes (IFAC-PapersOnline) | Year: 2013

This article presents an overview of the additive manufacturing (AM) area, as known as rapid prototyping and more recently as 3D printing, and its expected impact in logistics. The AM processes are classified in various categories and the most important processes are highlighted in this paper. Theoretically, any complex shape can be produced using AM that makes it very suitable for a fast and customized production. The applications for AM are expected to be present in the principal production chains and type of industry. It will impact as part production, systems or a complete product ranging from medical to aerospace industry. Therefore, this article discusses applications and new production paradigm that will affect in some extent the logistics the way it is today.? © IFAC. Source

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