Entity

Time filter

Source Type

Cluj-Napoca, Romania

Kacso I.M.,University of Medicine and Pharmacy, Cluj-Napoca | Potra A.R.,University of Medicine and Pharmacy, Cluj-Napoca | Bondor C.I.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan D.,University of Medicine and Pharmacy, Cluj-Napoca | And 11 more authors.
Clinical Biochemistry | Year: 2015

Objectives: Adiponectin is an insulin-sensitizing, anti-inflammatory adipokine with anti-atherogenic actions in the general population. In dialysis patients it is unclear whether adiponectin conserves its protective value or is, on the contrary, associated to worse prognosis. We assessed the predictive value of adiponectin for atherosclerosis related cardiovascular events in type 2 diabetic dialysis patients. Design and methods: Prevalent diabetic dialysis patients from three dialysis units (n = 77) were enrolled in a 3. years' prospective observational study. Serum adiponectin, clinical and laboratory parameters were determined at baseline; new occurrence of atherosclerosis related events (coronary events, atherosclerosis obliterans, and stroke) was recorded. Results: Baseline adiponectin was 17.25(9.53-31.97) μg/mL and significantly correlated to HDL cholesterol (r = 0.29, p = 0.01), triglycerides (r = -0.40, p = 0.0004), ferritin (r = -. 0.29, p = 0.02), transferrin (r = -. 0.28, p = 0.02), and uric acid (r = -. 0.24, p = 0.04). In multivariate analysis association to triglycerides (p = 0.001), HDL cholesterol (p = 0.01) and ferritin (p = 0.04) remained significant. 36 new fatal and non-fatal new cardiovascular events occurred, 29 patient died. Cox proportional regression analysis showed that adiponectin below or above a ROC-derived cut-off of 27.33. μg/mL significantly influenced event-free survival: hazard ratio (HR) 2.48, 95% confidence interval (CI) (1.09-5.66), p = 0.031 along with fasting glucose HR 1.01, 95%CI(1.00-1.02), p = 0.01 and history of cardiovascular events at inclusion HR 3.16, 95%CI(1.36-7.32), p = 0.007. In multivariate analysis baseline adiponectin HR 5.02, 95%CI(0.98-25.06), p = 0.05 and glycemia HR 1.01, 95%CI(1.00-1.02), p = 0.01 influenced event-free survival. Adiponectin also predicted cardiovascular events in patients without cardiovascular disease at inclusion but was not associated to overall mortality. Conclusions: In diabetes dialysis patients low adiponectin favors occurrence of atherosclerosis related cardiovascular events. © 2015 The Canadian Society of Clinical Chemists.


Kacso I.M.,University of Medicine and Pharmacy, Cluj-Napoca | Potra A.R.,University of Medicine and Pharmacy, Cluj-Napoca | Bondor C.I.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan D.,University of Medicine and Pharmacy, Cluj-Napoca | And 10 more authors.
Biomarkers | Year: 2015

Aim: To assess endothelial cell selective adhesion molecule (ESAM) as predictor of cardiovascular mortality in diabetic dialysis patients (DDPs). Methods: ESAM, clinical and laboratory parameters were assessed in 73 DDP. Cardiovascular mortality was recorded in a 2 years' prospective observational study. Results: Baseline ESAM was 17.1 (10.05-24.8) ng/ml and was correlated to phosphate (r = -0.42, p = 0.008), parathormone (r = -0.36, p = 0.048), albumin (r = -0.24, p = 0.048). ESAM significantly predicted cardiovascular death in univariate [HR = 1.03, 95% CI (1.006-1.054), p = 0.01] and multivariate [HR = 1.034, 95% CI (1.003-1.066), p = 0.03] Cox analysis. Time to cardiovascular death was shorter for patients with ESAM >12.44 ng/ml, p = 0.0045. Conclusion: ESAM is an independent predictor of cardiovascular mortality in DDP. © 2015 Informa UK Ltd. All rights reserved.

Discover hidden collaborations